SLIT-ROBO rho GTPase Activating Protein 3 Proteine (SRGAP3)

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. Zusätzlich bieten wir Ihnen SRGAP3 Antikörper (29) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SRGAP3 259302 Q812A2
Ratte SRGAP3 SRGAP3 500287  
SRGAP3 9901 O43295
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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SRGAP3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
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Weitere Proteine zu SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Interaktionspartnern

Mouse (Murine) SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Interaktionspartner

  1. SrGAP3 plays a role in neurodevelopmental disorders.

  2. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice.

  3. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins.

  4. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (zeige ARHGEF16 Proteine) cells.

  5. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus

  6. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.

  7. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14.

  8. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1.

  9. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.

  10. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner.

Human SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3) Interaktionspartner

  1. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains.

  2. Nuclear-localized srGAP3 interacts with Brg1 (zeige SMARCA4 Proteine). This interaction is mediated by the C-terminal of srGAP3 and the ATPase motif of Brg1 (zeige SMARCA4 Proteine).

  3. deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation.

  4. conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1

  5. Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes.

  6. We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation.

  7. Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions.

  8. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains.

SRGAP3 Protein Überblick

Protein Überblick

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

Genbezeichner und Symbole assoziert mit SRGAP3

  • SLIT-ROBO Rho GTPase activating protein 3 (Srgap3)
  • SLIT-ROBO Rho GTPase activating protein 3 (SRGAP3)
  • SLIT-ROBO Rho GTPase activating protein 3 (srgap3)
  • SLIT-ROBO Rho GTPase activating protein 2 L homeolog (srgap2.L)
  • AI452337 Protein
  • ARHGAP14 Protein
  • D130026O08Rik Protein
  • fnbp2 Protein
  • Gbi Protein
  • MEGAP Protein
  • mKIAA0411 Protein
  • RGD1563152 Protein
  • srgap2 Protein
  • WRP Protein

Bezeichner auf Proteinebene für SRGAP3

SLIT-ROBO Rho GTPase activating protein 2 , SLIT-ROBO Rho GTPase-activating protein 3 , WAVE-associated Rac GTPase-activating protein , brain stress early protein Gbi , rho GTPase activating protein 14 , rho GTPase-activating protein 14 , srGAP2 , WAVE-associated Rac GTPase activating protein , mental disorder-associated GAP , SLIT-ROBO Rho GTPase activating protein 2 L homeolog

GENE ID SPEZIES
259302 Mus musculus
500287 Rattus norvegicus
9901 Homo sapiens
610229 Canis lupus familiaris
561567 Danio rerio
100720492 Cavia porcellus
416115 Gallus gallus
447760 Xenopus laevis
100052590 Equus caballus
Ausgewählte Anbieter für SRGAP3 Proteine (SRGAP3)
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