anti-SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Antikörper

SHANK2 encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Zusätzlich bieten wir Ihnen SHANK2 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SHANK2 22941 Q9UPX8
SHANK2 210274 Q80Z38
SHANK2 171093 Q9QX74
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Top anti-SHANK2 Antikörper auf antikoerper-online.de

Showing 10 out of 146 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Säugetier Maus Unkonjugiert ISt, IHC, WB   5 mL Anmelden zum Anzeigen 2 bis 6 Tage
$366.67
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IP, WB Western blot analysis of SHANK2 expression in Jurkat (A), IMR32 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Maus Kaninchen Unkonjugiert WB SHANK2 Antibody (Center) (ABIN656710) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of SHANK2 Antibody (Center) in Mouse bladder tissue lysates (35ug/lane).This demonstrates the SHANK2 antibody detected the SHANK2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from RAW264.7/Jurkat/HepG2/COLO cells, using SHANK2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert AA, ICC, IF, IHC, IP, WB Shank2 Rat Brain Membrane Western Blotting. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$383.90
Details
Human Maus HRP AA, ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK2 Monoclonal Antibody, Clone S23b-6 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm . Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) SHANK2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of SHANK2 protein using Mouse Anti-SHANK2 Monoclonal Antibody, Clone S23b-6 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-SHANK2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$422.40
Details
Human Maus FITC AA, ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK2 Monoclonal Antibody, Clone S23b-6 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Cytoplasm . Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) SHANK2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of SHANK2 protein using Mouse Anti-SHANK2 Monoclonal Antibody, Clone S23b-6 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-SHANK2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$426.80
Details

SHANK2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-SHANK2 Antikörper

  1. Mammalian Monoclonal SHANK2 Primary Antibody für ISt, IHC - ABIN1304902 : Gill, Droubi, Giovedi, Fedder, Bury, Bosco, Sceniak, Benfenati, Sabo: Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo. in Journal of cell science 2015 (PubMed)
    Show all 26 Pubmed References

  2. Mammalian Monoclonal SHANK2 Primary Antibody für ISt, IHC - ABIN1304953 : Peykov, Berkel, Schoen, Weiss, Degenhardt, Strohmaier, Weiss, Proepper, Schratt, Nöthen, Boeckers, Rietschel, Rappold: Identification and functional characterization of rare SHANK2 variants in schizophrenia. in Molecular psychiatry 2015 (PubMed)
    Show all 12 Pubmed References

  3. Human Monoclonal SHANK2 Primary Antibody für AA, ICC - ABIN863120 : Nagura, Ishikawa, Kobayashi, Takao, Tanaka, Nishikawa, Tamura, Shiosaka, Suzuki, Miyakawa, Fujiyoshi, Doi et al.: Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 ... in Molecular brain 2013 (PubMed)

Weitere Antikörper gegen SHANK2 Interaktionspartner

Human SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Interaktionspartner

  1. We report a deletion including the SHANK2 gene in a female child with dysmorphic features, microcephaly, and global developmental delay, providing additional evidence for SHANK2 involvement in intellectual disability

  2. In one family, seven siblings with schizophrenia spectrum disorders each carry a novel private missense variant within the SHANK2 gene.

  3. The present study demonstrated that depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials in human stem cells from apical papilla

  4. variants in the SHANK2 gene in a schizophrenia patient cohort

  5. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR (zeige CFTR Antikörper).

  6. syndapin I (zeige PACSIN1 Antikörper) functions reflected direct, SH3 domain (zeige ITSN1 Antikörper)-mediated associations and functional interactions with ProSAP1/Shank2.

  7. Lack of association between NLGN3 (zeige NLGN3 Antikörper), NLGN4 (zeige NLGN4X Antikörper), SHANK2 and SHANK3 (zeige SHANK3 Antikörper) gene variants and autism spectrum disorder in a Chinese population.

  8. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate (zeige GRIN1 Antikörper) receptors at the synapse and increased levels of ProSAP2/Shank3 (zeige SHANK3 Antikörper)

  9. we confirmed that de novo SHANK2 deletions are present in patients with ASD (zeige ARSD Antikörper) and showed that several SHANK2 variants reduce the number of synapses in vitro

  10. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD (zeige ARSD Antikörper)

Mouse (Murine) SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2) Interaktionspartner

  1. location memory acquired in a head-fixed virtual environment. Encoding and updating of virtual cued goal location memory was impaired in Shank2-deficient mice that mimic a deletion found in human autistic patients and exhibit impaired spatial learning in a real environment. These results highlight the roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in virtual reality.

  2. Shank2 protein is involved in spinal NMDA receptor-mediated pain, and mutations of Shank2 may suppress NMDA-ERK (zeige EPHB2 Antikörper) signaling in spinal pain transmission.

  3. We found that Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors, but is not associated with autistic-like social deficits or repetitive behaviors.

  4. Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain.

  5. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice

  6. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW}

  7. Shank2 appears to be a key molecule regulating epithelial fluid secretion.

  8. syndapin I (zeige PACSIN1 Antikörper) functions reflected direct, SH3 domain (zeige ITSN1 Antikörper)-mediated associations and functional interactions with ProSAP1/Shank2.

  9. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses.

  10. Shank2 negatively regulates CFTR (zeige CFTR Antikörper) and this may play a significant role in maintaining epithelial homeostasis

SHANK2 Antigen-Profil

Protein Überblick

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Genbezeichner und Symbole assoziert mit SHANK2

  • SH3 and multiple ankyrin repeat domains 2 (SHANK2) Antikörper
  • SH3 and multiple ankyrin repeat domains 2 (Shank2) Antikörper
  • SH3 and multiple ankyrin repeat domains 2 L homeolog (shank2.L) Antikörper
  • SH3 and multiple ankyrin repeat domains 2 (shank2) Antikörper
  • SH3 and multiple ankyrin repeat domains protein 2 (LOC100438523) Antikörper
  • auts17 Antikörper
  • CortBP1 Antikörper
  • cttnbp1 Antikörper
  • MGC122482 Antikörper
  • mKIAA1022 Antikörper
  • prosap1 Antikörper
  • SHANK Antikörper
  • SHANK2 Antikörper
  • Spank-3 Antikörper

Bezeichner auf Proteinebene für SHANK2

GKAP/SAPAP interacting protein , SH3 and multiple ankyrin repeat domains protein 2 , cortactin SH3 domain-binding protein , cortactin-binding protein 1 , proline-rich synapse associated protein 1 , proline-rich synapse-associated protein 1 , cortBP1 , SH3 and multiple ankyrin repeat domains 2 , SH3/ankyrin domain gene 2 , SH3 and multiple ankyrin repeat domains protein 2-like , GKAP/SAPAP-interacting protein , proline rich synapse associated protein 1

GENE ID SPEZIES
22941 Homo sapiens
210274 Mus musculus
428858 Gallus gallus
483677 Canis lupus familiaris
734458 Xenopus laevis
100124731 Xenopus (Silurana) tropicalis
100338286 Oryctolagus cuniculus
100412179 Callithrix jacchus
171093 Rattus norvegicus
466694 Pan troglodytes
618649 Bos taurus
708192 Macaca mulatta
100031879 Monodelphis domestica
100438523 Pongo abelii
100579795 Nomascus leucogenys
100732196 Cavia porcellus
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