SH2B Adaptor Protein 3 Proteine (SH2B3)

SH2B3 encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. Zusätzlich bieten wir Ihnen SH2B3 Antikörper (77) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SH2B3 10019 Q9UQQ2
SH2B3 16923 O09039
SH2B3 58838 P50745
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$765.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,008.50
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Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$781.00
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SH2B3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu SH2B Adaptor Protein 3 (SH2B3) Interaktionspartnern

Human SH2B Adaptor Protein 3 (SH2B3) Interaktionspartner

  1. Clinical significance of novel SH2B3 mutations in adult Chinese acute lymphoblastic leukemia patients.

  2. Loss of SH2B3 contributes to disease progression and raises the possibility that these leukemias may be sensitive to tyrosine kinase inhibitors.

  3. The R262W polymorphism is associated with risk of coronary heart disease or myocardial infarction in Europeans, but not in Asians.

  4. Significant associations were found for SH2B3 T allele and PTPN22 A allele and autoimmune hepatitis

  5. As a novel finding, our study suggests a role for KCNK5 in the regulation of platelet size and maturity. Furthermore, our findings confirm an association between the SH2B3-locus and platelet count.

  6. Single-nucleotide polymorphism in SH2B3 gene is associated with Hashimoto's thyroiditis.

  7. four selected single-nucleotide polymorphisms (SNPs) in the SH2B3 gene were genotyped in 158 patients with AIH, 327 patients with primary biliary cholangitis, 160 patients with autoimmune pancreatitis, and 325 healthy subjects of Japanese descent. Our findings suggest that an SNP and haplotype in SH2B3 are associated with Autoimmune hepatitis.

  8. In conclusion, germ line LNK mutations rarely occur in familial myeloproliferative neoplasms (MPNs) and do not segregate with the disease phenotype. The findings suggest that mutations in LNK, either germ line or acquired, may cooperate with acquired driver mutations in JAK2, CALR, or MPL to determine disease phenotype in MPNs.

  9. indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros dysfunction

  10. Elevated expression of Lnk in polycystic ovary syndrome suggests that Lnk probably plays a role in the development of insulin resistance.

  11. Hypercholesterolemia acts in platelets and hematopoietic progenitors to exacerbate thrombosis and atherosclerosis associated with SH2B3 deficiency.

  12. The polymorphisms in LNK gene correlated to the clinical type of myeloproliferative neoplasms regardless of the JAK2 polymorphism.

  13. SH2B3 mutations occur infrequently, and exon 8 in SH2B3 may be the most frequent mutational area in BCR-ABL negative myeloproliferative neoplasms patients in Korea.

  14. LNK/SH2B3 is a key driver gene for human hypertension, and alteration of LNK in animal models has a profound effect on inflammation and hypertension. Thus, LNK is a potential therapeutic target for this disease and its devastating consequences.

  15. Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.

  16. results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.

  17. the minor allele A of rs3184504 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in SH2B3 significantly increased celiac disease susceptibility (Meta-Analysis)

  18. A number of mutations in LNK have been described in a variety of myeloproliferative neoplasms some of which have been demonstrated to cause increased cellular proliferation.

  19. The single-nucleotide polymorphism in SH2B3 was significantly associated with Hypertension in an Algerian population sample.

  20. Genetic variations in inflammation and its related subpathway components are keys to the development of lung, colorectal, ovary, and breast cancer, including SH2B3, which is associated with lung, colorectal, and breast cancer.

Mouse (Murine) SH2B Adaptor Protein 3 (SH2B3) Interaktionspartner

  1. Data indicate that linker of T-cell receptor pathways protein(Lnk) deficiency restores phenotypic hematopoietic stem cells (HSCs) in Fanconi anemia, complementation group D2 protein knockout (Fancd2-/-) mice.

  2. Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype

  3. Specific targeting of Lnk may be a promising EPC-based therapeutic strategy for dermal wound healing.

  4. The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction.

  5. We found that a significant number of genes predicted to be regulated by SH2B3 in gene networks are perturbed in Sh2b3(-/-) mice, which demonstrate an exaggerated pressor response to angiotensin II infusion.

  6. results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.

  7. SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure.

  8. Loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension.

  9. Lnk/Sh2b3 plays a regulatory role in the expansion of Dendritic cells and might influence inflammatory immune responses in peripheral lymphoid tissues.

  10. results reveal a link between Lnk and immune cell-mediated intestinal tissue destruction.

  11. IL-11 therefore drives a pathway that enhances HSPC radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk.

  12. Report that Lnk siRNA-transfected endothelial commitment of c-kit+/Sca-1+/lineage bone marrow cells have high hematopoietic stem/endothelial progenitor cells (EPCs) colony-forming capacity exhibiting endothelial markers, VE-Cad, VEGF and Ang-1.

  13. the loss of SH2B3 inhibitory function conferred by the PH domain mutations is mild and may collaborate with JAK2 V617F and CBL mutations in order to promote either the development or the progression of myeloproliferative neoplasms.

  14. Lnk deficiency partially mitigates hematopoietic stem cell aging.

  15. that the SH2B3 mutation is absent in NOD mice. To our knowledge, this is the first report of the sequence and the protein levels of SH2B3 in NOD mice

  16. 14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells

  17. LNK as a stroke-specific, endogenous negative regulator of neural stem and progenitor cell proliferation

  18. Hematopoietic stem cells in patients with an Lnk/Sh2b3 mutation might become resistant to apoptosis due to thrombopoietin-mediated enhanced expression of Bcl-xL.

  19. Loss of Foxo3 causes a myeloproliferative syndrome with increased intracellular ROS, overactive intracellular signalling through the AKT/mTOR signalling pathway and relative deficiency of Lnk, a negative regulator of cytokine receptor signalling.

  20. the loss of Lnk signaling enhances the regenerative response during fracture healing

SH2B3 Protein Überblick

Protein Überblick

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.

Genbezeichner und Symbole assoziert mit SH2B Adaptor Protein 3 Proteine (SH2B3)

  • SH2B adaptor protein 3 (SH2B3)
  • SH2B adaptor protein 3 (Sh2b3)
  • AI429800 Protein
  • IDDM20 Protein
  • Lnk Protein

Bezeichner auf Proteinebene für SH2B Adaptor Protein 3 Proteine (SH2B3)

lymphocyte adaptor protein , SH2B adapter protein 3 , lymphocyte-specific adapter protein Lnk , signal transduction protein Lnk , linker of T-cell receptor pathways , lymphocyte adapter protein

GENE ID SPEZIES
452245 Pan troglodytes
710839 Macaca mulatta
10019 Homo sapiens
16923 Mus musculus
58838 Rattus norvegicus
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