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SH2B3 encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. Zusätzlich bieten wir Ihnen SH2B3 Antikörper (81) und viele weitere Produktgruppen zu diesem Protein an.
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As a novel finding, our study suggests a role for KCNK5 in the regulation of platelet size and maturity. Furthermore, our findings confirm an association between the SH2B3-locus and platelet count.
Single-nucleotide polymorphism in SH2B3 gene is associated with Hashimoto's thyroiditis.
four selected single-nucleotide polymorphisms (SNPs) in the SH2B3 gene were genotyped in 158 patients with AIH, 327 patients with primary biliary cholangitis, 160 patients with autoimmune pancreatitis, and 325 healthy subjects of Japanese descent. Our findings suggest that an SNP and haplotype in SH2B3 are associated with Autoimmune hepatitis.
In conclusion, germ line LNK mutations rarely occur in familial myeloproliferative neoplasms (MPNs) and do not segregate with the disease phenotype. The findings suggest that mutations in LNK, either germ line or acquired, may cooperate with acquired driver mutations in JAK2 (zeige JAK2 Proteine), CALR (zeige CALR Proteine), or MPL (zeige MPL Proteine) to determine disease phenotype in MPNs.
indicate that IL7RhighSH2B3low expression distinguishes a novel subset of high-risk B-acute lymphoblastic leukemia associated with Ikaros (zeige IKZF1 Proteine) dysfunction
Elevated expression of Lnk in polycystic ovary syndrome suggests that Lnk probably plays a role in the development of insulin (zeige INS Proteine) resistance.
Hypercholesterolemia acts in platelets and hematopoietic progenitors to exacerbate thrombosis and atherosclerosis associated with SH2B3 deficiency.
The polymorphisms in LNK gene correlated to the clinical type of myeloproliferative neoplasms regardless of the JAK2 (zeige JAK2 Proteine) polymorphism.
SH2B3 mutations occur infrequently, and exon 8 in SH2B3 may be the most frequent mutational area in BCR-ABL (zeige ABL1 Proteine) negative myeloproliferative neoplasms patients in Korea.
LNK/SH2B3 is a key driver gene for human hypertension, and alteration of LNK in animal models has a profound effect on inflammation and hypertension. Thus, LNK is a potential therapeutic target for this disease and its devastating consequences.
Lnk Deficiency Leads to TPO (zeige THPO Proteine)-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
Specific targeting of Lnk may be a promising EPC (zeige TCF21 Proteine)-based therapeutic strategy for dermal wound healing.
The LNK plays a regulatory role in the palmitate-related preadipocyte apoptosis and might be involved in adipose tissue dysfunction.
We found that a significant number of genes predicted to be regulated by SH2B3 in gene networks are perturbed in Sh2b3(-/-) mice, which demonstrate an exaggerated pressor response to angiotensin II infusion.
results suggest that LNK suppresses IL-7R/JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.
SH2B3 functions as a novel and effective modulator of cardiac remodeling and failure.
Loss of LNK in hematopoietic cells is primarily responsible for the observed renal and vascular inflammation and predisposition to hypertension.
Lnk/Sh2b3 plays a regulatory role in the expansion of Dendritic cells and might influence inflammatory immune responses in peripheral lymphoid tissues.
results reveal a link between Lnk and immune cell-mediated intestinal tissue destruction.
IL-11 (zeige IL11 Proteine) therefore drives a pathway that enhances HSPC (zeige PSMA7 Proteine) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk.
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.
lymphocyte adaptor protein
, SH2B adapter protein 3
, lymphocyte-specific adapter protein Lnk
, signal transduction protein Lnk
, linker of T-cell receptor pathways
, lymphocyte adapter protein