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Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves.
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we show that variants in ROBO1 are associated with CHD (zeige CHDH ELISA Kits) involving septal defects and tetralogy of Fallot.
SLIT2 (zeige SLIT3 ELISA Kits)/ROBO1 signalling may regulate trophoblast differentiation and invasion causing restricting beta human chorionic gonadotrophin (beta-hCG (zeige CGA ELISA Kits)) production, shallow trophoblast invasion and inhibiting placental angiogenesis in missed and threatened miscarriage during the first trimester.
The findings indicate that the migration of human neural progenitor cells from the fetal subventricular zone to the olfactory bulb is partially regulated by the Slit2 (zeige SLIT3 ELISA Kits)-Robo1 axis.
These findings offer direct evidence supporting ROBO1-callosum association in humans and also provide valuable insight into the functions of ROBO1 and the gene-to-brain mechanisms that underlie human reading.
Differential expression levels and methylation status of ROBO1 in mantle cell lymphoma and chronic lymphocytic leukaemia.
The alteration of Slit2 (zeige SLIT3 ELISA Kits) and Robo1 expression in the retinas of diabetic rats and patients with proliferative diabetic retinopathy suggests a role for the Slit-Robo signal in the various stages diabetic retinopathy.
Results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.
ROBO1 gene mutation is responsible for the development of pituitary stalk interruption syndrome.
human placental multipotent mesenchymal stromal cell express Slit2 (zeige SLIT3 ELISA Kits) and both Robo1 and Robo4 (zeige ROBO4 ELISA Kits) are present in human umbilical vein endothelial cells.
Slit2 (zeige SLIT3 ELISA Kits)-Robo1 signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 (zeige MMP2 ELISA Kits) and MMP9 (zeige MMP9 ELISA Kits) and, downregulating the expression of E-cadherin (zeige CDH1 ELISA Kits).
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
deleted in U twenty twenty
, roundabout homolog 1