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The protein encoded by RNF31 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.
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Cow (Bovine) Polyclonal RNF31 Primary Antibody für WB - ABIN2774753
Kirisako, Kamei, Murata, Kato, Fukumoto, Kanie, Sano, Tokunaga, Tanaka, Iwai: A ubiquitin ligase complex assembles linear polyubiquitin chains. in The EMBO journal 2006
Show all 9 Pubmed References
Human Polyclonal RNF31 Primary Antibody für ELISA, WB - ABIN249637
Varfolomeev, Izrael-Tomasevic, Yu, Bustos, Goncharov, Belmont, Masselot, Bakalarski, Kirkpatrick, Vucic: Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment. in The Biochemical journal 2015
Show all 4 Pubmed References
The binding of SHARPIN (zeige SHARPIN Antikörper) or HOIL-1L (zeige RBCK1 Antikörper) facilitates the E2 loading of HOIP.
SPATA2 (zeige SPATA2 Antikörper) has been described as a previously unrecognized factor in the linear ubiquitin chain assembly complex-dependent signaling pathways that serves as an adaptor between HOIP and CYLD (zeige CYLD Antikörper), thereby enabling recruitment of CYLD (zeige CYLD Antikörper) to signaling complexes.
This review highlights recent discoveries on RNF31 functions in nuclear factor modifications, breast cancer progression and possible therapeutic inhibitors targeting RNF31. [review]
The data reveal SPATA2 (zeige SPATA2 Antikörper) as a high-affinity binding partner of CYLD (zeige CYLD Antikörper) and HOIP, and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (zeige NFKB1 Antikörper) signaling.
LUBAC components control TLR3 (zeige TLR3 Antikörper)-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation.
Study found that RNF31 is cleaved under apoptosis conditions through various stimulations; findings elucidate a novel regulatory loop between cell death and the survival signal
These results indicate that caspase (zeige CASP3 Antikörper)-mediated cleavage of HOIP divides critical functional regions of HOIP, and that this regulates linear (de)ubiquitination of substrates upon apoptosis.
RNF31 decreased p53 (zeige TP53 Antikörper) stability. RNF31 depletion caused cell cycle arrest and cisplatin-induced apoptosis in a p53 (zeige TP53 Antikörper)-dependent manner. RNF31 associated with the p53 (zeige TP53 Antikörper)/MDM2 (zeige MDM2 Antikörper) complex, facilitating p53 (zeige TP53 Antikörper) polyubiquitination and degradation by stabilizing MDM2 (zeige MDM2 Antikörper).
This study describes a novel posttranslational regulation of the HOIP-containing linear-ubiquitin-chain assembly complex (LUBAC)-mediated linear ubiquitination that is critical for specifically directing TLR4 (zeige TLR4 Antikörper)-mediated NF-kappaB (zeige NFKB1 Antikörper) activation.
These findings collectively indicated an oncogene (zeige RAB1A Antikörper) role of RNF31 in PCa (zeige FLVCR1 Antikörper) progression which can be regulated by miR (zeige MLXIP Antikörper)-503, suggesting that RNF31 could serve as a potential prognostic biomarker and therapeutic target for PCa (zeige FLVCR1 Antikörper).
HOIP's catalytic activity is necessary for preventing TNF (zeige TNF Antikörper)-induced cell death. Hence, LUBAC and its linear-ubiquitin-forming activity are required for maintaining vascular integrity during embryogenesis by preventing TNFR1 (zeige TNFRSF1A Antikörper)-mediated endothelial cell death.
Restoration of HOIP expression reversed the defects in cellular activation and signaling. These results reveal HOIP as a key component of the CD40 (zeige CD40 Antikörper) signaling pathway
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions.
ring finger protein 31
, E3 ubiquitin-protein ligase RNF31
, HOIL-1-interacting protein
, zinc in-between-RING-finger ubiquitin-associated domain protein
, RING finger protein 31
, putative Ariadne-like ubiquitin ligase