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RNF125 encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus.
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study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 (zeige TRIM14 Proteine) in the innate antiviral immune response
Data indicate that brain from Japanese encephalitis virus (JEV)-infection showed a reciprocal correlation between microRNA miR-15b levels and the ex (zeige MLXIP Proteine)pression of ring finger protein 125 (RNF125).
RNF125 is enhanced by IFN, these functions constitute a negative regulatory loop circuit for IFN production
for the ubiquitin ligase RNF125 that, in addition to the RING domain, a C2HC Zn finger (ZnF) is crucial for activity.
high RNF125 expression is related with aggressive characteristics and unfavorable prognosis of GBC patients; RNF125 promotes the invasion and metastasis of human GBCs via activating the TGF-beta1 (zeige TGFB1 Proteine)-SMAD3 (zeige SMAD3 Proteine)-ID1 (zeige ID1 Proteine) signaling pathway.
we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas
Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR) of ring finger protein 125 (RNF125) is a potential microRNA miR (zeige MLXIP Proteine)-15b targeting site.
studies of the RNF125 pathway point to upregulation of RIG-I (zeige DDX58 Proteine)-IPS1 (zeige MAVS Proteine)-MDA5 (zeige IFIH1 Proteine) and/or disruption of the PI3K (zeige PIK3CA Proteine)-AKT (zeige AKT1 Proteine) and interferon (zeige IFNA Proteine) signaling pathways as the putative final effectors
In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I (zeige DDX58 Proteine) is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25 (zeige TRIM25 Proteine).
study reports human bocavirus VP2 modulates IFN pathway by targeting the ring finger protein 125, a negative regulator of type I IFN signaling, which conjugates Lys (zeige LYZ Proteine)(48)-linked ubiquitination to retinoic acid-inducible gene-I (zeige DDX58 Proteine) and leads to the proteasome-dependent degradation of RIG-I (zeige DDX58 Proteine)
These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway.
TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.
E3 ubiquitin-protein ligase RNF125
, T-cell RING activation protein 1
, T-cell ring protein identified in activation screen