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Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Zusätzlich bieten wir Ihnen RPL3 Antikörper (80) und und viele weitere Produktgruppen zu diesem Protein an.
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The sensitivity of p53 (zeige TP53 Proteine) null colon cancer cells to 5-FU can be enhanced using proapoptotic rpL3 gene.
nucleolar stress induced by 5-fluorouracil in colon cancer cells devoid of p53 leads to the activation of ribosomal protein L3 as proapoptotic factor
We found that uL3 down-regulation correlates positively with multidrug resistance. Restoration of the uL3 protein level re-sensitized the resistant cells to the drug by regulating the reactive oxygen species (ROS (zeige ROS1 Proteine)) levels, glutathione content, glutamate (zeige GRIN1 Proteine) release, and cystine uptake.
rpL3 participates in the cell response to chemotherapy acting as a critical regulator of cell cycle (zeige C13orf15 Proteine), apoptosis and DNA repair, by modulating p21 (zeige CDKN1A Proteine) expression
The rpL3 is able to modulate the protein amounts of p21 (zeige CDKN1A Proteine) through a novel pathway independent from p53 (zeige TP53 Proteine) involving Sp1 (zeige PSG1 Proteine) and NPM (zeige NPM1 Proteine).
NPM (zeige NPM1 Proteine) and KHSRP (zeige KHSRP Proteine) are two newly identified proteins involved in the regulation of rpL3 gene expression via alternative pre-mRNA splicing.
working model in which rpL3 recruits hnRNP H1 and, through cooperation with other splicing factors, promotes selection of the alternative splice site
RPL3L (zeige RPL3L Proteine) expression significantly impaired myotube growth as assessed by myotube diameter
Knockdown or mutation of either rpl3 or pes resulted in impaired expansion of pancreatic progenitor cells.
This study showed that beta-actin (zeige ACTB Proteine), L32 (zeige RPL32 Proteine) ribosomal protein, and ATP5B (zeige ATP5B Proteine) proteins were the most stabily expressed genes in cryopreserved horse semen.
Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
60S ribosomal protein L3
, HIV-1 TAR RNA-binding protein B
, hypothetical protein
, ribosomal protein L3 homolog
, ribosomal protein L3