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RGR encodes a putative retinal G-protein coupled receptor.
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study to systemically analyze the potential role of variants of RGR in retinal diseases results of the suggested that the heterozygous truncation variants in RGR were less likely to be pathogenic
conclude that the ability of hRgr to activate both Ral and Ras is responsible for its transformation-inducing phenotype and it could be an important contributor in the development of some T-cell malignancies
It is likely that mutations in RGR, RBP3 (zeige E2F1 Antikörper), and possibly RBP1 (zeige ARID4A Antikörper) occur rarely in inherited retinal dystrophies.
Human rgr: transforming activity and alteration in T-cell malignancies [rgr: ralGDS (zeige RALGDS Antikörper)-related]
E150K opsin (zeige RHO Antikörper) is partially colocalized with the cis (zeige CISH Antikörper)/medial Golgi compartment but not with the trans-Golgi network; results are consistent with recessive pattern of inheritance; retinal degeneration results from deficient export of opsin (zeige RHO Antikörper) from the Golgi
These results indicate that after exon-skipping RGR splice isoform (RGR-d) is synthesized, the RGR-d epitope is released at the basal surface of the retinal pigment epithelium and deposited into Bruch's membrane in human eyes throughout adult life.
RGR-opsin mediates light-dependent translocation of all-trans-retinyl esters from a storage pool in lipid droplets to an "isomerase pool" in membranes of the endoplasmic reticulum.
the exon-skipping variant of RGR (RGR-d) is found in extracellular deposits;at the base of early-stage drusen mounds in the older donors and may precede the formation of these drusen
structure of rhodopsin (zeige RHO Antikörper) and opsin (zeige RHO Antikörper) dimer in native membranes
The role of Rgr using rgr-/- single and rdh5 (zeige RDH5 Antikörper)-/-rgr-/- double knockout mice under a number of light conditions was studied; results suggest that RGR and RDH5 (zeige RDH5 Antikörper) are likely to function in the retinoid cycle, although their role is not essential
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.
, RPE retinal G-protein coupled receptor
, RPE-retinal G protein-coupled receptor
, RGR opsin
, retinal g-protein receptor opsin
, rgr opsin
, retinal G protein coupled receptor
, retinal G-protein coupled receptor
, Ral-GDS related protein Rgr
, RalGDS related oncogene
, ral-GDS-related protein
, ralGDS-like 4