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RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. Zusätzlich bieten wir Ihnen Regulatory Factor X, 1 (Influences HLA Class II Expression) Antikörper (46) und viele weitere Produktgruppen zu diesem Protein an.
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RFX1 expression was significantly lower in HCC (zeige FAM126A Proteine) tissues compared to the corresponding non-tumor tissues. In vitro studies suggested that knocking down RFX1 facilitated HCC (zeige FAM126A Proteine) cell invasion, while overexpression of RFX1 reduced the invasion of HCC (zeige FAM126A Proteine) cells. RFX1 regulated expression of some epithelial-mesenchymal transition markers.
Findings indicate that RFX1 functions downstream of STAT3 (zeige STAT3 Proteine) and phosphorylated STAT3 (zeige STAT3 Proteine) can inhibit RFX1 expression and suggest a unique role for RFX1 in Th17-related autoimmune diseases.
Results show that reduced miRNA-124 improved microglia activation and up-regulated its downstream target RFX1, indicating that RFX1, as one of the target transcripts, facilitates microglial activation by miR (zeige MLXIP Proteine)-124 regulation; identified the binding site through which RFX1 directly regulates ApoE (zeige APOE Proteine), may explain the missing link between decreased miRNA-124 and ineffective Abeta (zeige APP Proteine) uptaking during aging.
induction of ciliogenesis increases the expression of RFX and dyslexia candidate genes
Data show that transcription factor regulatory factor X 1 (RFX1) protein expression can be tightly regulated by polyubiquitination-mediated proteosomal degradation via STIP1 homology and U-box containing protein 1 (STUB1 (zeige STUB1 Proteine)).
Data indicate that regulatory factor X transcription factor RFX-1 regulates SC-2001-mediated SHP-1 Phosphatase transcription in hepatocellular carcinoma cells.
regulatory factor 1 directly regulates CD44 (zeige CD44 Proteine) expression in glioblastoma
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs (zeige TWIST1 Proteine).
RFX1 reduces cell proliferation through inhibiting the TGFbeta2-ERK (zeige EPHB2 Proteine) signaling pathway. RFX1 blocks TGFbeta2 expression through its direct action on TGFbeta2 transcription.
NLRC5-mediated histocompatibiility class I gene induction requires the W/S and X1, X2 cis (zeige CISH Proteine)-regulatory elements.
RFX1 transcriptionally targets Itga6 (zeige ITGA6 Proteine) in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development.
This study suggests that ciliogenic Rfx transcription factors regulate Msi1 (zeige MSI1 Proteine) expression in neural stem/progenitor cells.
RFX1 may have negative effect on cell proliferation of Sertoli cells via modulating Spata4 expression levels by binding the conserved 14-bp cis-elements of Spata4 promoter.
Rfx1 could be an indicator of progression from Barrett's esophagus to adenocarcinoma.
These results suggest a significant expression of RFX1 proteins in the mammalian brain.
RFX1 may negatively regulate the self-renewal of GBM-SCs (zeige TWIST1 Proteine) through modulating FGF-1B and FGF1 (zeige FGF1 Proteine) expression levels by binding the 18-bp cis (zeige CISH Proteine)-elements of the F1B promoter.
RFX1 may play roles in haploid cells during mouse spermatogenesis
RFX1 mediates the immediate early (zeige JUN Proteine) response of the Id2 gene by serum stimulation and suggest that the function of RFX1 is regulated intramolecularly in its suppression in growth-arrested cells.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.
MHC class II regulatory factor RFX
, MHC class II regulatory factor RFX1
, enhancer factor C
, regulatory factor X 1
, trans-acting regulatory factor 1
, transcription factor RFX1
, vregulatory factor X, 1 (influences HLA class II expression)
, regulatory factor X1