Receptor Protein Tyrosine Phosphatase Proteine (PTPRT)

The protein encoded by PTPRT is a member of the protein tyrosine phosphatase (PTP) family.

alle Proteine anzeigen Gen GeneID UniProt
Human PTPRT PTPRT 11122 O14522
Maus PTPRT PTPRT 19281 Q99M80
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details

Weitere Proteine zu Receptor Protein Tyrosine Phosphatase (PTPRT) Interaktionspartnern

Human Receptor Protein Tyrosine Phosphatase (PTPRT) Interaktionspartner

  1. The single cell genotyping not only confirmed the co-occurrence of the PTPRT, CAND1 and DOCK6 mutations in the same AML clone but also revealed a clonal hierarchy, as the PTPRT mutation was likely acquired after the CAND1 and DOCK6 mutations.

  2. PTPRT promoter methylation is significantly associated with sensitivity to STAT3 (zeige STAT3 Proteine) inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 (zeige STAT3 Proteine) inhibitors in clinical development

  3. Data reported evidence that rs2866943 polymorphism in PTPRT 3'-UTR was involved in the occurrence of esophageal squamous cell carcinoma by acting as a protective factor while rs6029959 acts as a risk factor.

  4. Data show that hepatitis B virus X protein mutant HBxDelta127 enhances proliferation of hepatoma cells through up-regulating miR (zeige MLXIP Proteine)-215 targeting protein tyrosine phosphatase (zeige ACP1 Proteine), receptor type T (PTPRT).

  5. tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3 (zeige STAT3 Proteine), a potent oncogenic transcription factor and PTPRT substrate

  6. [review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs (zeige PTS Proteine) in human colon cancers, providing critical cancer genetics evidence that PTPs (zeige PTS Proteine) can act as tumour suppressor genes.

  7. Data show that paxillin (zeige PXN Proteine) is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin (zeige PXN Proteine) phosphorylation at tyrosine residue 88(Y88).

  8. alterations of the PTPRT-mediated signaling pathway by PTPRT phosphatase domain mutation may not play a critical role in the development of common human cancers

  9. STAT3 (zeige STAT3 Proteine) is a substrate of receptor protein tyrosine phosphatase T

  10. brain-specific (zeige CALY Proteine) PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase (zeige TXK Proteine) Fyn (zeige FYN Proteine).

Mouse (Murine) Receptor Protein Tyrosine Phosphatase (PTPRT) Interaktionspartner

  1. Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum.

  2. These studies implicate PTPRT-modulated STAT3 (zeige STAT3 Proteine) signaling in the regulation of high-fat diet-induced obesity

  3. BCR (zeige BCR Proteine) is a novel substrate of PTPRT .

  4. Data show that paxillin (zeige PXN Proteine) is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin (zeige PXN Proteine) phosphorylation at tyrosine residue 88(Y88).

PTPRT Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Genbezeichner und Symbole assoziert mit PTPRT

  • protein tyrosine phosphatase, receptor type T (PTPRT)
  • protein tyrosine phosphatase, receptor type, T (Ptprt)
  • mKIAA0283 Protein
  • RPTP-rfo Protein
  • RPTPrho Protein

Bezeichner auf Proteinebene für PTPRT

R-PTP-T , RPTP-rho , receptor protein tyrosine phosphatase , receptor-type tyrosine-protein phosphatase T , receptor-type tyrosine-protein phosphatase rho , RPTPmam4 , mRPTPrho , receptor protein tyrosine phosphatase-rho

GENE ID SPEZIES
11122 Homo sapiens
19281 Mus musculus
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