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RASSF1 encodes a protein similar to the RAS effector proteins. Zusätzlich bieten wir Ihnen Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteine (8) und Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 137 products:
Human Polyclonal RASSF1 Primary Antibody für IF (p), IHC (p) - ABIN673764
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
Show all 2 Pubmed References
Human Monoclonal RASSF1 Primary Antibody für FACS, ICC - ABIN4349434
Joo, Kim, Park, Yoo, Choe, Kim, Lee, Kim, Bak: CpG island promoter hypermethylation of Ras association domain family 1A gene contributes to gastric carcinogenesis. in Molecular medicine reports 2015
Human Polyclonal RASSF1 Primary Antibody für ICC, IF - ABIN442332
Liu, Sun, Fong, Yang, Zhang, Yin, Jiang, Liu, Ju, Huang, Bai, Gong, Yan, Zhang, Shao: An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma. in Oncotarget 2017
Mouse (Murine) Polyclonal RASSF1 Primary Antibody für ELISA - ABIN451615
Yan, Venkataramu, Ibrahim, Liu, Shen, Diaz, Centeno, Weber, Leu, Shapiro, Eng, Yeatman, Huang: Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Data show that silencing DNA methyltransferase 1 (DNMT1 (zeige DNMT1 Antikörper)) increased expression of tumor suppressor genes, RASSF1A and DAPK (zeige DAPK1 Antikörper), in esophageal squamous cell carcinoma (ESCC) cells and ESCC xenograft in nude mice.
Describe a novel interaction between Rheb and the tumor suppressor RASSF1A. This interaction may allow coordinate upregulation of Hippo while TOR is suppressed to modulate the balance of apoptosis and autophagy in lung tumor cells.
Nine of the 32 (28.1%) iCCA (zeige PRRT2 Antikörper) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (zeige RNF2 Antikörper) mutations, two each (6.3%) of CACNA2D3 (zeige CACNA2D3 Antikörper) and RASSF1 mutations, and one each (3.1%) of ATG7 (zeige ATG7 Antikörper) and PLCD1 (zeige PLCD1 Antikörper) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
Gestational age-dependent increase of hypermethylated RASSF1A; the fetal specific epigenetic marker in maternal plasma was demonstrated, in an Indian study group of normal pregnant women.
the RASSF1 gene polymorphism influences molecular carcinogenesis and clinic pathological features of hepatocellular carcinoma within the Egyptian population
We report for the first time that RASSF1A promoter methylation provides significant prognostic information in high-grade serous ovarian cancer patients.
The main finding of this study was the significant association between RASSF1A promoter methylation and increased EC risk.
Data suggest that the overexpression of DNMT3B4 may play an important role in human kidney tumorigenesis through chromosomal instability and methylation of RASSF1A.
Methylation status of the RASSF1A gene promoter was strongly related to melanoma susceptibility but no significant difference was found between RASSF1A gene promoter methylation and the prognosis and clinical-pathological features of melanoma.
In response to TGF-beta (zeige TGFB1 Antikörper), RASSF1A is recruited to TGF-beta (zeige TGFB1 Antikörper) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (zeige MUL1 Antikörper) ITCH. RASSF1A degradation is necessary to permit Hippo pathway effector YAP1 (zeige YAP1 Antikörper) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2 (zeige SMAD2 Antikörper).
essential role of RASSF1A in regulating TNF-alpha (zeige TNF Antikörper) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (zeige TNFRSF1A Antikörper) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (zeige NFKB1 Antikörper) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (zeige RUNX2 Antikörper) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (zeige TP53 Antikörper) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (zeige CCND2 Antikörper), p16 (zeige CDKN2A Antikörper), RAR-beta (zeige RARB Antikörper) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (zeige APC Antikörper) resulting in accelerated intestinal tumourigenesis.
RASSF1A mediates p21Cip1/Waf1 (zeige CDKN1A Antikörper)-dependent cell cycle arrest and senescence through modulation of the Raf (zeige RAF1 Antikörper)-MEK (zeige MDK Antikörper)-ERK (zeige EPHB2 Antikörper) pathway and inhibition of Akt (zeige AKT1 Antikörper).
data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2