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The protein encoded by RACGAP1 belongs to the GTPase-activating protein (GAP) family. Zusätzlich bieten wir Ihnen RACGAP1 Antikörper (137) und RACGAP1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA (zeige RHOA ELISA Kits) and Erk (zeige EPHB2 ELISA Kits) proteins, thus up-enhance the migration and invasion process of EOC.
Data show that comparing with Ki-67 (zeige MKI67 ELISA Kits) and TOP2A (zeige TOP2A ELISA Kits), RacGAP1 allowed for a clearer prognostic statement.
RACGAP1 promotes the metastatic phenotype in uterine carcinosarcoma via a STAT3 (zeige STAT3 ELISA Kits)/survivin (zeige BIRC5 ELISA Kits) signaling pathway.
High RACGAP1 expression is associated with Basal-like Breast Cancers.
Data suggest that MGCRABGAP is involved in mammalian spermiogenesis by modulating RAB10 (zeige RAB10 ELISA Kits).
This study showed that the overexpressions of Ki67 (zeige MKI67 ELISA Kits), RacGAP1, and TOP2a (zeige TOP2A ELISA Kits) affect the prognosis of female breast cancer patients adversely
Data confirmed a strong correlation of AURKA (zeige AURKA ELISA Kits) and Wnt (zeige WNT2 ELISA Kits)-modulator RACGAP1 gene expression both in the gastric tumor, the tumor-adjacent and the tumor-distant mucosa.
RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma
RACGAP1 expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.
central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis.
MgcRacGAP SxIP motif is functionally important both for its role in regulating adherens junction structure during interphase and for regulating Rho GTPase activity during cytokinesis.
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
APC (zeige APC ELISA Kits)(CDH1 (zeige CDH1 ELISA Kits)) targets MgcRacGAP for destruction in the late M phase.
TLR4 (zeige TLR4 ELISA Kits) signaling shapes B cell dynamics via MyD88 (zeige MYD88 ELISA Kits)-dependent pathways and Rac (zeige AKT1 ELISA Kits) GTPases.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (zeige AKT1 ELISA Kits), CDC42 (zeige CDC42 ELISA Kits), and RhoG small GTPase activities
Rac (zeige AKT1 ELISA Kits) regulates vascular endothelial growth factor (zeige VEGF ELISA Kits) stimulated motility
These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.
alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase (zeige PIK3CA ELISA Kits)-Cdc42 (zeige CDC42 ELISA Kits)/Rac (zeige AKT1 ELISA Kits) pathways may play a role in determining the size and shape of tooth germ
Gab2 (zeige GAB2 ELISA Kits) via Shp-2 (zeige PTPN11 ELISA Kits) is critical for transmitting signals from Kit Tyr (zeige TYR ELISA Kits)(567) to activate the Rac (zeige AKT1 ELISA Kits)/JNK (zeige MAPK8 ELISA Kits) pathway controlling mast cell proliferation
Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP.
Rac (zeige AKT1 ELISA Kits) became activated within 2 min after peripheral membrane extensions adhered to new ECM (zeige MMRN1 ELISA Kits) islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island
In vivo cell recordings reveal that gradual loss of wild-type RacGAP1 leads progressively from a failure of abscission, then to cleavage furrow ingression, and finally complete absence of furrow formation. Despite the lack of cytokinesis, gross patterning occurs overtly normally in ogre mutants and cells continue to cycle slowly, some even attaining four or eight nuclei.
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
GTPase activating protein
, male germ cell RacGap
, protein CYK4 homolg
, protein CYK4 homolog
, rac GTPase-activating protein 1
, Rac GTPase-activating protein 1
, Rac GTPase activating protein 1
, rac GTPase-activating protein 1-like