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Putative signaling adapter which may play a role in neuronal differentiation.
Showing 4 out of 4 products:
RUN domain of NESCA can bind H-Ras (zeige HRAS Proteine), a downstream signaling molecule of TrkA (zeige NTRK1 Proteine), with high affinity. Moreover, NESCA RUN can directly interact with TrkA (zeige NTRK1 Proteine).
Nesca functions as an adapter involved in neuronal vesicular transport
Data show that NESCA and NEMO (zeige IKBKG Proteine) interact by their N-terminal region, that NESCA directly associates with TRAF6 (zeige TRAF6 Proteine), which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6 (zeige TRAF6 Proteine)-mediated polyubiquitination of NEMO (zeige IKBKG Proteine).
Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin (zeige BDNF Proteine)-dependent neurite outgrowth.
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (By similarity).
RUN and SH3 domain containing 1
, RUN and SH3 domain-containing protein 1
, new molecule containing SH3 at the carboxy-terminus