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RBM8A encodes a protein with a conserved RNA-binding motif. Zusätzlich bieten wir Ihnen RNA Binding Motif Protein 8A Antikörper (34) und RNA Binding Motif Protein 8A Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Results demonstrated that RBM8A is highly expressed in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), and patients with lower RBM8A expression level had longer overall survival and progression free survival. Also, results indicate that RBM8A promotes invasion and metastasis via epithelial-mesenchymal transition signaling pathway.
Y14 may selectively and differentially modulate protein biosynthesis.
this data suggests a novel role of RBM8a in the regulation of neurodevelopment.
Mutations of RBM8A and TBX6 (zeige TBX6 Proteine) are associated with disorders of the mullerian ducts.
It was demonstrated that Rbm8a is an essential neurogenesis regulator in embryonic cortical development.
Depletion of RNA-binding protein (zeige PTBP1 Proteine) RBM8A (Y14) causes cell cycle deficiency and apoptosis in human tumor cells.
Y14 positively regulates signals for TNF-alpha (zeige TNF Proteine)-induced IL-6 (zeige IL6 Proteine) production at multiple steps beyond an exon junction complex protein.
Y14 mutants, which are deficient in binding to Magoh (zeige MAGOH Proteine), could still be localized to the nucleus, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh (zeige MAGOH Proteine)
Data show that Y14 interacts directly with the decapping factor Dcp2 (zeige DCP2 Proteine) and the 5' cap structure of mRNAs via different but overlapping domains.
findings show that the two regulatory SNPs result in diminished RBM8A transcription in vitro and that Y14 expression is reduced in platelets from individuals with thrombocytopenia with absent radii (TAR)
Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a (zeige GSK3a Proteine) phosphorylate splicing factors (Rbm8a, Srsf9 (zeige SFRS9 Proteine), and Psf (zeige IL-3 Proteine)) and nucleolar proteins (Npm1 (zeige GJA1 Proteine) and Phf6 (zeige PHF6 Proteine)); Gsk3b/Gsk3a (zeige GSK3a Proteine) are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3 (zeige GSK3a Proteine); Rbm8a = RNA binding motif protein 8a; Srsf9 (zeige SFRS9 Proteine) = splicing factor (zeige SLU7 Proteine), arginine-serine-rich 9; Psf (zeige IL-3 Proteine) = replication protein Psf (zeige IL-3 Proteine); Npm1 (zeige GJA1 Proteine) = nucleophosmin 1 (zeige NPM1 Proteine); Phf6 (zeige PHF6 Proteine) = PHD finger protein 6 (zeige PHF6 Proteine))
we first show that Eif4a3 (zeige EIF4A3 Proteine) haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh (zeige MAGOH Proteine) and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53 (zeige TP53 Proteine), significantly rescues microcephaly of all 3 EJC mutant
This is the first study that demonstrates the key role of RBM8a on the emotional behaviors in mice.
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B\; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.
RNA binding motif protein 8A
, RNA-binding motif protein 8A
, RNA-binding protein 8A
, Ribonucleoprotein RBM8A
, RNA binding motif protein 8B
, RNA-binding protein Y14
, binder of OVCA1-1
, ribonucleoprotein RBM8
, ribonucleoprotein RBM8A
, RNA binding motif protein 8
, RNA-binding motif protein 8A-A
, RNA-binding protein 8A-A
, Ribonucleoprotein RBM8A-A