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The protein encoded by RAD18 is highly similar to S. Zusätzlich bieten wir Ihnen RAD18 Proteine (6) und RAD18 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 103 products:
Human Monoclonal RAD18 Primary Antibody für IF, IHC (p) - ABIN566046
Hicks, Chute, Paulsen, Ragland, Howlett, Guéranger, Glover, Canman: Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. in Molecular and cellular biology 2010
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Mouse (Murine) Polyclonal RAD18 Primary Antibody für IF, IP - ABIN2452085
Sun, Yomogida, Sakao, Yamamoto, Yoshida, Watanabe, Morita, Araki, Yamamura, Tateishi: Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. in Mechanisms of development 2009
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Human Polyclonal RAD18 Primary Antibody für IF, IP - ABIN2452086
Tateishi, Sakuraba, Masuyama, Inoue, Yamaizumi: Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. in Proceedings of the National Academy of Sciences of the United States of America 2000
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Human Polyclonal RAD18 Primary Antibody für IP, PLA - ABIN253202
Williams, Longerich, Sung, Vaziri, Kupfer: The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. in Blood 2011
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Human Monoclonal RAD18 Primary Antibody für WB - ABIN252484
Lyakhovich, Shekhar: Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response. in Molecular and cellular biology 2003
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Human Polyclonal RAD18 Primary Antibody für IP - ABIN253201
Wagner, Karnitz: Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. in Molecular pharmacology 2009
Cow (Bovine) Polyclonal RAD18 Primary Antibody für WB - ABIN2774765
Tsuji, Watanabe, Araki, Shinohara, Yamagata, Tsurimoto, Hanaoka, Yamamura, Yamaizumi, Tateishi: Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. in Genes to cells : devoted to molecular & cellular mechanisms 2008
Data suggest that, as part of DNA repair in nucleus of embryonic stem cells, IGF1R (zeige IGF1R Antikörper) interacts with and phosphorylates PCNA (zeige PCNA Antikörper) at tyrosine residues 60, 133, and 250; this is followed by mono- and polyubiquitination of PCNA (zeige PCNA Antikörper) by RAD18 and SHPRH (zeige SHPRH Antikörper). (IGF1R (zeige IGF1R Antikörper) = insulin-like growth factor 1 receptor (zeige IGF1R Antikörper); PCNA (zeige PCNA Antikörper) = proliferating cell nuclear antigen (zeige PCNA Antikörper); RAD18 = E3 ubiquitin-protein ligase RAD18; SHPRH (zeige SHPRH Antikörper) = E3 ubiquitin-protein ligase SHPRH (zeige SHPRH Antikörper))
Ubiquitin ligases RNF168 (zeige RNF168 Antikörper), RNF169 (zeige RNF169 Antikörper), and RAD18 specifically bind histone H2A Lys13/15-ubiquitylated nucleosomes. 53BP1 (zeige TP53BP1 Antikörper) chromatin recruitment may be activated by RNF168 (zeige RNF168 Antikörper) and blocked by RNF169 (zeige RNF169 Antikörper) and RAD18.
WRNIP1 (zeige WRNIP1 Antikörper) connects PCNA (zeige PCNA Antikörper) monoubiquitination with ATMIN (zeige ATMIN Antikörper)/ATM (zeige ATM Antikörper) to activate ATM (zeige ATM Antikörper) signalling in response to replication stress and contribute to the maintenance of genomic stability.
RAD18 polymorphisms are correlated with the side effects of platinum-chemotherapy in Chinese patients with advanced NSCLC.
REV1 (zeige REV1 Antikörper) can promote (zeige PCNA Antikörper)PCNA monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
USP7 (zeige USP7 Antikörper)-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway
RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.
Significantly restored tolerance of RAD18-/- and RNF8 (zeige RNF8 Antikörper)-/- cells to camptothecin and olaparib without affecting Rad51 (zeige RAD51 Antikörper) focus formation.
these results suggest that miR (zeige MLXIP Antikörper)-145 can act as an RAD18 inhibitor and contribute as an important factor in reversing drug resistance after chemotherapy.
We obtained a molecular envelope for Rad18 UBZ-ELRM:linear Ub2 polyubiquitin (zeige UBB Antikörper) chains by small-angle X-ray scattering and derived a structural model for the complex.
Somatic hypermutation of immunoglobulin genes (SHM (zeige CNTNAP1 Antikörper)) in Rad18 KO mice was similar to wild-type mice, suggesting that Rad18 is dispensable for SHM (zeige CNTNAP1 Antikörper).
Rad18 confers DNA damage tolerance and tumor-suppression in a physiological setting.
REV1 promote PCNA (zeige PCNA Antikörper) monoubiquitylation after UV radiation through interacting with ubiquitylated RAD18.
RAD18 contributes to maintenance of genomic stability through postreplication repair
Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase
Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.
RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
E3 ubiquitin-protein ligase RAD18
, RAD18, S. cerevisiae, homolog
, RING finger protein 73
, postreplication repair protein RAD18
, postreplication repair protein hRAD18p
, post-replication repair protein RAD18SC
, RAD18 homolog (S. cerevisiae)
, similar to postreplication repair protein hRAD18p
, E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
, hypothetical protein
, DNA repair protein and ATPase
, SAP DNA-binding domain-containing protein
, RAD18 homolog
, RAD18-like protein
, E3 ubiquitin-protein ligase RAD18-like
, e3 ubiquitin-protein ligase RAD18-like