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Western blot experiments designed to detect flotillin 2 (zeige FLOT2 Proteine), TMEM256, Rab3B and LAMTOR1 (zeige LAMTOR1 Proteine) showed that the level of these proteins was higher in urinary exosomes from prostate cancer patients compared to healthy males
The structure of Rab3B:GDP complex was solved to 1.9A resolution and the structural base comparison with other Rab3 (zeige RAB3A Proteine) members provides a structural basis for the GDP/GTP (zeige AK3 Proteine) switch in controlling the activity of small GTPase (zeige RACGAP1 Proteine).
These results support an important inter-species difference in regulating insulin (zeige INS Proteine) exocytosis where RAB3B is the most expressed isoform in human islets.
RAB3B improves dopamine handling and storage capacity at presynaptic terminals, and confers protection to vulnerable DA neurons.
these results add new information to the view that Rab3B is involved in the regulation of pituitary hormone (zeige CGA Proteine) secretion.
Rab3b/3c-positive recycling vesicles are involved in and may constitute one of the recycling compartments in exogenous antigen cross-presentation.
Presynaptic forms of long-term plasticity at excitatory and inhibitory synapses generally are mediated by a common Rab3 (zeige RAB3A Proteine)/RIM-dependent pathway, with various types of synapses using distinct Rab3 (zeige RAB3A Proteine) isoforms.
Rab3 (zeige RAB3A Proteine)-induced modifications to primed vesicles causes a transient increase in the transduction efficacy of synaptic action potential trains and optimizes the encoding of synaptic information at an intermediate spike frequency range.
Gas8 (zeige GAS8 Proteine) was specifically interacted with the GTP (zeige AK3 Proteine)-bound form of Rab3B and co-localized with Rab3B at the Golgi in NIH 3T3 cells
Protein transport. Probably involved in vesicular traffic (By similarity).
RAB3B, member RAS oncogene family
, ras-related protein Rab-3B
, Ras-related protein Rab-3B
, brain antigen RAB3B
, SMG P25B