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The protein encoded by RAB18 is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Zusätzlich bieten wir Ihnen RAB18 Antikörper (35) und RAB18 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet.
RAB18 modulates macroautophagy and proteostasis, and is dependent on activity of RAB3GAP1 (zeige RAB3GAP1 ELISA Kits) and RAB3GAP2 (zeige RAB3GAP2 ELISA Kits).
findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people.
RAB18 is the direct target of miR (zeige MLXIP ELISA Kits)-455-5p in gastric cancer.
Warburg Micro syndrome is caused by RAB18 deficiency.
These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets.
High RAB18 expression is associated with glioma.
Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication.
Rab18 and a Rab18 GEF complex of Rab3GAP1 (zeige RAB3GAP1 ELISA Kits) and Rab3GAP2 (zeige RAB3GAP2 ELISA Kits) have roles in the endoplasmic reticulum structure
Rab18 interacts with the HCV nonstructural protein NS5A.
RAB18 regulates neuronal migration and morphogenesis during development.
Retinoid and cholesterol metabolism are linked in stellate cells by the LD-associated protein Rab18 and may have significant therapeutic benefit in liver fibrosis.
The results of this study indicated that the sensory nervous system is more vulnerable to Rab18 deficiency and WARBM is not only a neurodevelopmental but also neurodegenerative disease.
apparent similarities between the WARBM phenotype and the phenotype that we describe here indicate that the Rab18-mutant mouse provides an important platform for investigation of the disease pathogenesis and therapeutic interventions
Data suggest that overexpression of Rab18 in its GDP-bound state favors peroxisome proliferation in hepatocytes; Rab18 (as well as Rab6 (zeige RAB6A ELISA Kits), Rab10 (zeige RAB10 ELISA Kits), and Rab14 (zeige RAB14 ELISA Kits)) localizes to the peroxisomal compartment.
Rab18 regulates lipid droplet-associated membrane formation
results show that a Rab (zeige HRB ELISA Kits) protein localizes directly to the monolayer surface of lipid droplets
in neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport
Rab18 is ubiquitously expressed in endocrine and nonendocrine tissues, and shows intracellular distributions associated with discrete vesicular and tubular structures of the secretory pathway.
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
RAB18 small GTPase
, ras-related protein Rab-18
, GTP-binding protein Rab18
, RAB18, member RAS oncogene family
, Ras-related protein Rab-18
, RAB18, member RAS oncogene family S homeolog