Proteinase 3 Proteine (PRTN3)

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.. Zusätzlich bieten wir Ihnen Proteinase 3 Antikörper (175) und Proteinase 3 Kits (53) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PRTN3 5657 P24158
PRTN3 314615  
PRTN3 19152 Q61096
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Top Proteinase 3 Proteine auf antikoerper-online.de

Showing 10 out of 24 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
Details
Escherichia coli (E. coli) Human GST tag Proteinase 3 (PRTN3) (AA 28-248), (full length) protein (GST tag) 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$242.00
Details
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 4 bis 8 Tage
$394.90
Details
Escherichia coli (E. coli) Human GST tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
Details
Escherichia coli (E. coli) Maus Unkonjugiert SDS-PAGE analysis of Mouse Proteinase 3 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$497.47
Details

PRTN3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,

Weitere Proteine zu Proteinase 3 (PRTN3) Interaktionspartnern

Human Proteinase 3 (PRTN3) Interaktionspartner

  1. The lung extracellular matrix is vulnerable to pathological structural changes upon upregulation of serine proteases, including cathepsin G (CG) and proteinase 3 (PR3).

  2. PR3 is involved in triggering inflammatory pathways, disrupting cellular signalling, degrading key structural proteins, and pathogen response.PR3 dysfunction may play a critical role in many processes central to the pathophysiology of COPD and other chronic neutrophilic human diseases.

  3. Characterization of the CD177 interaction with the ANCA antigen proteinase 3 responsible for autoimmune diseases has been reported.

  4. Our results demonstrate that in the early stage of sepsis, JMJD3 contributes to high levels of neutrophil mPR3 expression and thereby to the production of the inflammatory cytokine IL-1beta

  5. A few peptides bound to proteinase 3 (PR3) hydrophobic pockets and inhibited PR3 binding to lipids, while the (KFF)3K d-peptide inshowed a significant affinity for the lipids.

  6. Studies indicate that the premature activation of proteinase 3 (PR3) would seriously harm the cell by its protease activity.

  7. this study shows that transgenic mice expressing human Proteinase 3 exhibit sustained neutrophil-associated peritonitis

  8. unique structural and functional characteristics of PR3 might be key contributors to the systemic inflammation and to the immune dysregulation observed in granulomatosis with polyangiitis.

  9. Our findings demonstrate how RAGE-PR3 interactions between human prostate cancer cells and the bone marrow microenvironment mediate bone metastasis during prostate cancer progression

  10. PRTN3 variants are associated with ANCA-associated vasculitis risk.

  11. Clinical manifestations varied ANCA-associated vasculitis categories, and neither MPO-ANCA nor PR3-ANCA significantly affected relapse of AAV.

  12. Changes in the DNA methylation status of the PRTN3 promoter may predict the likelihood of stable remission and explain autoantigen gene regulation

  13. Study shows that MPO and PRTN3 in neutrophils of Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients with active disease have a distinct pattern of histone modifications, which implicates epigenetic mechanisms in regulating expression of autoantigen genes and suggests that the epigenome may be involved in AAV pathogenesis.

  14. The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.

  15. Report prognostic value of proteinase-3-antineutrophil cytoplasmic antibody in patients with idiopathic interstitial pneumonias.

  16. Molecular simulations suggest that PR3 interacts with phosphatidylserine via a small number of amino acids, which engage in long lasting interactions with the lipid heads. As phosphatidylserine is a major component of microvesicles (MVs), this study also examined the consequences of this interaction on MV production and function.

  17. miR-634 mimics induced a proinflammatory phenotype in monocyte-derived macrophages, with enhanced expression and release of ADAM17 and IL-6 in Proteinase-3 ANCA-Associated Vasculitis

  18. The PR3-induced microenvironment facilitated recruitment of inflammatory cells, such as macrophages, plasmacytoid DCs (pDCs), and neutrophils, which were observed in close proximity within granulomatous lesions in the lungs of GPA patients.

  19. ACPA negative rheumatoid arthritis shares the genetic susceptibility loci with ACPA positive disease.

  20. Data suggest that targeting proteinase-3 (PR3) specific effector memory cells, to prevent relapse, and instituting anti IL-17 therapy, or modulating Tregs could be newer forms of therapy for granulomatosis with polyangiitis (GPA).

Mouse (Murine) Proteinase 3 (PRTN3) Interaktionspartner

  1. Results provide evidence that proteinase 3 as a new factor involved in non-alcoholic fatty liver disease and insulin resistance.

  2. In different murine models of apoptotic cell injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation.

  3. PR3-ANCA is a promising biomarker in primary sclerosing cholangitis.

  4. Proteinase 3-mediated caspase-3 activation controls neutrophil spontaneous death

  5. Increased PRTN3 activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  6. Phagocytosis of apoptotic PR3-expressing cells potentiates proinflammatory cytokines in vivo by resident murine peritoneal macrophages.

  7. the dual functions (activation/termination) of PR3 in IL-33 biological activity.

  8. pathogenic effect of proteinase 3-specific antineutrophil cytoplasmic autoantibodies at local sites of inflammation.

  9. Murine and human proteinase 3 complexes have different interaction patterns with peptidic substrates.

  10. PR3 and neutrophil elastase enhance neutrophil-dependent inflammation by eliminating the local antiinflammatory activity of progranulin. Our results support the use of serine protease inhibitors as antiinflammatory agents.

  11. Neutrophil-derived PR3 can proteolyze high-molecular weight kininogen and liberate PR3-kinin, thereby initiating kallikrein-independent activation of the kinin pathway

Proteinase 3 (PRTN3) Protein Überblick

Protein Überblick

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Genbezeichner und Symbole assoziert mit Proteinase 3 Proteine (PRTN3)

  • proteinase 3 L homeolog (prtn3.L)
  • proteinase 3 (PRTN3)
  • proteinase 3 (Prtn3)
  • ACPA Protein
  • AGP7 Protein
  • C-ANCA Protein
  • CANCA Protein
  • ela2 Protein
  • MBN Protein
  • MBT Protein
  • MGC132250 Protein
  • mPR3 Protein
  • NP-4 Protein
  • NP4 Protein
  • P29 Protein
  • PR-3 Protein
  • PR3 Protein

Bezeichner auf Proteinebene für Proteinase 3 Proteine (PRTN3)

proteinase 3 , C-ANCA antigen , Wegener granulomatosis autoantigen , azurophil granule protein 7 , leukocyte proteinase 3 , myeloblastin , neutrophil proteinase 4 , serine proteinase, neutrophil , wegener autoantigen , PR-3

GENE ID SPEZIES
496090 Xenopus laevis
5657 Homo sapiens
314615 Rattus norvegicus
19152 Mus musculus
100298591 Bos taurus
Ausgewählte Anbieter für Proteinase 3 Proteine (PRTN3)
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