Protein tyrosine Phosphatase, Non-Receptor Type 3 Proteine (PTPN3)

The protein encoded by PTPN3 is a member of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen PTPN3 Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTPN3 5774 P26045
PTPN3 545622 A2ALK8
Ratte PTPN3 PTPN3 362524  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
685,71 €
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HOST_Escherichia coli (E. coli) Maus T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
731,43 €
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PTPN3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,

Weitere Proteine zu Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3) Interaktionspartnern

Human Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3) Interaktionspartner

  1. Results indicate that protein tyrosine phosphatase non-receptor type 3 (PTPN3) may act as a tumor suppressor in lung cancer through its modulation of epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) signaling.

  2. analysis of how allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation

  3. These studies thus identified PTPH1 as a novel ER phosphatase and further demonstrate a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH1.

  4. Activating mutations in and high expression levels of PTPN3 were associated with tumor recurrence in cholangiocarcinoma.

  5. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.

  6. The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced.

  7. PTPH1 stimulated breast cancer growth through regulating vitamin D receptor (zeige VDR Proteine) expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis.

  8. PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma (zeige MAPK12 Proteine)-binding activity. Ras increases p38gamma (zeige MAPK12 Proteine) and PTPH1 expression and there is a coupling of increased p38gamma (zeige MAPK12 Proteine) and PTPH1 protein expression in colon cancer.

  9. regulates TACE (tnf-alpha convertase (zeige ADAM17 Proteine)}

  10. first reported demonstration that protein tyrosine phosphatase H1(PTPH1) is capable of interacting with and dephosphorylating T cell receptor zeta subunit

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 3 (PTPN3) Interaktionspartner

  1. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.

  2. PTP-H1 has a role in modulating GHR (zeige GHR Proteine) signaling and systemic growth through insulin-like growth factor 1 (zeige IGF1 Proteine) secretion

  3. PTPN3 and PTPN4 are dispensable for TCR signal transduction.

PTPN3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PTPN3

  • protein tyrosine phosphatase, non-receptor type 3 (PTPN3)
  • protein tyrosine phosphatase, non-receptor type 3 (Ptpn3)
  • 9530011I20Rik Protein
  • PTP-H1 Protein
  • PTPCL Protein
  • PTPH1 Protein

Bezeichner auf Proteinebene für PTPN3

cytoskeletal-associated protein tyrosine phosphatase , protein-tyrosine phosphatase H1 , tyrosine-protein phosphatase non-receptor type 3

GENE ID SPEZIES
5774 Homo sapiens
545622 Mus musculus
362524 Rattus norvegicus
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