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putative protein tyrosine phosphatase based on sequence information, may be involved in signal transduction and/or protein amino acid dephosphorylation. Zusätzlich bieten wir Ihnen Protein Tyrosine Phosphatase, Non Receptor Type 23 Antikörper (46) und und viele weitere Produktgruppen zu diesem Protein an.
Mutations in PTPN23 gene is associated with developmental and epileptic encephalopathy.
HD-PTP/PTPN23 as a prominent haploinsufficient tumor suppressor gene preventing tumor progression through control of integrin trafficking.
the underlying mechanism of PTPN23 function in breast tumorigenesis as that of a key phosphatase that normally suppresses the activity of FYN (zeige FYN ELISA Kits)
The role of HD-PTP/PTPN23 in cancer and tumorigenesis is reviewed.
Results present crystal structures of the coiled-coil domain of the HD-PTP phosphatase and its complex with UBAP1 (zeige UBAP1 ELISA Kits). The coiled-coil domain adopts an unexpected open and rigid conformation. The HD-PTP:UBAP1 structure identifies the molecular determinants of the interaction and provides a molecular basis for the specific functional cooperation between HD-PTP and UBAP1 (zeige UBAP1 ELISA Kits).
HD-PTP acts as an alternative to ESCRT-II (zeige VPS28 ELISA Kits) and VPS20/CHMP6 (zeige CHMP6 ELISA Kits) as a link between the ESCRT-I (zeige VPS28 ELISA Kits) and those ESCRT-III protein(s) necessary for ILV formation.
Data indicate a regulatory function of non-receptor-type tyrosine phosphatase PTPN23 in maintaining a highly phosphorylated state of survival motor neuron (zeige SMN1 ELISA Kits) complex protein SMN (zeige STMN1 ELISA Kits).
PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR (zeige MLXIP ELISA Kits)-142-3p plays an important role in the pathogenesis of testicular germ cell tumors.
The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR (zeige EGFR ELISA Kits)) and combines with the deubiquitinating enzyme UBPY/USP8 (zeige USP8 ELISA Kits) to transfer EGFR (zeige EGFR ELISA Kits) from ESCRT-0 to ESCRT-III and drive EGFR (zeige EGFR ELISA Kits) sorting to intralumenal vesicles.
our findings suggest an evolutionarily conserved function of HDPTP-Rab4 (zeige RAB4A ELISA Kits) in the regulation of endocytic trafficking, cell adhesion and migration
HD-PTP affects the intracellular sorting of activated PDGFRbeta and the migration, proliferation and tumorigenicity of cells stimulated by PDGF (zeige PDGFA ELISA Kits).
homozygous gene deletion is lethal around embryonic day 9.5, suggesting that Ptpn23 is an essential requirement for early stages of embryonic development
putative protein tyrosine phosphatase based on sequence information, may be involved in signal transduction and/or protein amino acid dephosphorylation
His-domain protein tyrosine phosphatase
, his domain-containing protein tyrosine phosphatase
, protein tyrosine phosphatase TD14
, tyrosine-protein phosphatase non-receptor type 23