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PRC1 encodes a protein that is involved in cytokinesis. Zusätzlich bieten wir Ihnen PRC1 Proteine (6) und PRC1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Results mechanistically explain how the two conserved, essential midzone proteins PRC1 and Xklp1 cooperate to constitute a minimal protein module capable of dynamically organizing the core structure of the central anaphase spindle.
We finally confirmed that PRC1 is a novel downstream target of piperlongumine in gastric cancer. Our findings supported the oncogenic role of PRC1 in gastric carcinogenesis. PRC1 might serve as a prognostic biomarker and potential therapeutic target for gastric carcinoma.
These findings suggest that the identified APLP2 (zeige APLP2 Antikörper), RRM2 (zeige RRM2 Antikörper), and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
Near-atomic cryo-electron microscopy structure of PRC1 bound to the microtubule has been described.
study reveals that UbE2E1 (zeige UBE2E1 Antikörper) is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys (zeige LYZ Antikörper)-119 monoubiquitination
PRC1 is a novel Wnt (zeige WNT2 Antikörper) target that functions in a positive feedback loop that reinforces Wnt (zeige WNT2 Antikörper) signalling to promote early Hepatocellular Carcinoma recurrence.
PRC1 rs10520699 and rs11852999 polymorphisms were associated with PRC1 transcript levels, but not with patients survival.
These findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with prostate cancer highlighting its potential as a prognostic marker of this malignancy.
PP2A (zeige PPP2R4 Antikörper)-B55 (zeige MINK1 Antikörper) dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL (zeige MASTL Antikörper)) kinase and its substrate ENSA (zeige ENSA Antikörper), explaining the timing of PRC1 activation in anaphase.
PRC1 complexes isolated from human cells contain multiple kinesins KIF4A (zeige KIF4A Antikörper), Kif20A (zeige KIF20A Antikörper), KIF23 (zeige KIF23 Antikörper) and KIF14 (zeige KIF14 Antikörper).
PRC1 is a docking partner for the Polo kinase (zeige PLK1 Antikörper) Plk1 (zeige PLK1 Antikörper) in anaphase cells. During metaphase this is inhibited by Cdk1 (zeige CDK1 Antikörper)-cyclin B phosphorylation at T470 and T481.
Authors analyzed whether elevated levels of the polycomb (zeige CBX2 Antikörper) repressor complex 1 (PRC1) components Bmi1 (zeige BMI1 Antikörper) and Ring1b (zeige RNF2 Antikörper) and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
Here, the authors discover that the histone H2AK119 E3 ubiquitin ligase (zeige MUL1 Antikörper) activity of Polycomb (zeige CBX2 Antikörper) repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP (zeige RYBP Antikörper)/YAF2 (zeige YAF2 Antikörper)-dependent stimulation.
Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7 (zeige CBX7 Antikörper)-PRC1 complex to chromatin.
Pcgf6 (zeige PCGF6 Antikörper) is essential for recruitment of PRC1.6 to chromatin. Our results reveal a previously uncharacterized, H2AK119ub1-independent chromatin assembly associated with PRC1.6 complex
The data reveal how the interplay between PRC1, ncRNA and Mediator complexes controls pluripotency and cellular differentiation.
our findings show that PRC1 mediates gene repression by combining multiple and different effector mechanisms, of which H2A ubiquitination is a major contributor
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants.
protein regulator of cytokinesis 1
, anaphase spindle elongation 1 homolog
, protein regulating cytokinesis 1