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Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. Zusätzlich bieten wir Ihnen PPP4C Antikörper (114) und PPP4C Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos
PP4 (zeige ANXA5 ELISA Kits) regulates breast cancer cell survival and identifies a novel PP4c-PEA15 (zeige PEA15 ELISA Kits) signalling axis in the control of breast cancer cell survival.
Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c (zeige PPP6C ELISA Kits) compared to expression levels of PP2Ac.
Data show that protein phosphatase 4 catalytic subunit (PP4C) knockdown decreases glioma cell proliferation.
mutual regulatory mechanisms exist between PP4 (zeige ANXA5 ELISA Kits) and SAF-A (zeige HNRNPU ELISA Kits). Interactions between PP4 (zeige ANXA5 ELISA Kits) and SAF-A (zeige HNRNPU ELISA Kits) played a role in prometaphase/metaphase transition.
These data suggested a potential role of PP4C in tumor progression.
Stathmin plays an essential role of in Merkel cell polyomavirus small tumor antigen-mediated microtubule destabilization and cell motility and this process is regulated by cellular phosphatase catalytic subunit of protein phosphatase 4.
PP4 (zeige ANXA5 ELISA Kits) and Wip1 (zeige PPM1D ELISA Kits) are differentially required to counteract the p53 (zeige TP53 ELISA Kits)-dependent cell cycle arrest in G1 and G2, by antagonizing early or late p53 (zeige TP53 ELISA Kits)-mediated responses, respectively
Results show PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis.
Data indicate that the major phosphatase responsible for dephosphorylation of of BAF (zeige BANF1 ELISA Kits) Ser (zeige SIGLEC1 ELISA Kits)-4 to be protein phosphatase 4 catalytic subunit.
Recombinant gamma-tubulin (zeige TUBG1 ELISA Kits) can be phosphorylated by Cdk1 (zeige CDK1 ELISA Kits)-cyclin B or Brsk1 (zeige BRSK1 ELISA Kits) and dephosphorylated by Ppp4c-R2-R3A in vitro.
LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.
T cell-specific ablation of PP4 (zeige ANXA5 ELISA Kits) resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation.
Data show that protein phosphatase 4 (PP4 (zeige ANXA5 ELISA Kits)) is an important regulator in inflammatory related insulin (zeige INS ELISA Kits) resistance.
Thus, serine/threonine phosphatase PP4 (zeige ANXA5 ELISA Kits) functions as a novel feedback negative regulator of RNA virus-triggered innate immunity.
Taken together, our results establish a novel role for PP4 (zeige ANXA5 ELISA Kits) in CSR (zeige SCARA3 ELISA Kits), and reveal crucial functions for PP4 (zeige ANXA5 ELISA Kits) in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.
PP4 (zeige ANXA5 ELISA Kits) overexpression was observed to lead to a decreased pACC1Ser79/ACC1 (zeige ACACA ELISA Kits) ratio and subsequently an increased intracellular triglyceride content in mouse primary hepatocytes.
Mammalian SMEK/PP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2 (zeige CRTC2 ELISA Kits).
Protein phosphatase 4 has a role in apoptosis.
PP4 is essential for thymocyte development and pre-TCR signaling
PP4 (zeige ANXA5 ELISA Kits) negatively regulated LPS (zeige TLR4 ELISA Kits)-induced and TRAF6 (zeige TRAF6 ELISA Kits)-mediated NF-kappaB (zeige NFKB1 ELISA Kits) activation by inhibiting the ubiquitination of TRAF6 (zeige TRAF6 ELISA Kits).
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
protein phosphatase 4, catalytic subunit
, catalytic subunit
, serine/threonine-protein phosphatase 4 catalytic subunit A
, protein phosphatase 4 (formerly X), catalytic subunit
, protein phosphatase X, catalytic subunit
, serine/threonine-protein phosphatase 4 catalytic subunit
, protein phosphatase X