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PPP1R9A is imprinted, and located in a cluster of imprinted genes on chromosome 7q12.
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two homologs neurabin and spinophilin (zeige PPP1R9B Antikörper) play important yet distinct roles in the regulation of anxiety- and depression-like behaviors in an age-dependent manner.
Data indicate that In arrestin 3 (zeige ARRB2 Antikörper) deficient mice, where the alpha2B (zeige ADRA2B Antikörper) adrenergic receptor has a stronger binding to spinophilin (zeige PPP1R9B Antikörper), the hypertensive response is enhanced.
Ppp1r9a gene, found in a cluster of imprinted genes on chromosome 6, is preferentially expressed from the maternal allele at embryonic stages, but biallelically expressed in neonatal tissues.
The spinophilin (zeige PPP1R9B Antikörper) interactome was charaterized in subcellular fractions solubilized from adult rodent striatum.
there is a novel PP1gamma1-selective interaction domain in neurabin that may allow for selective regulation and/or subcellular targeting of PP1 isoforms
Neurabin I mediates Rac3-induced neuritogenesis, possibly by anchoring Rac3 to growth cone F-actin.
These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin (zeige PPP1R9B Antikörper) and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response.
results indicate that neurabin regulates contextual fear memory and LTP (zeige SCP2 Antikörper) in hippocampal CA1 (zeige CA1 Antikörper) pyramidal neurons
MARCKS (zeige MARCKS Antikörper) and PPP1R9A might contribute to spine loss in schizophrenia and bipolar disorder through their interactions.
CHN2 (zeige CHN2 Antikörper), ABCB1 (zeige ABCB1 Antikörper) and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.
Studies suggest that any change in substrate specificity of the spinophilin : PP1 holoenzyme complex was probably due to direct modification of a PP1 substrate binding surface.
PPP1R9A gene is imprinted, with preferential expression from the maternal allele in embryonic skeletal muscle and extra-embryonic tissues, but biallelic expression in other embryonic tissues.
This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, neural tissue-specific F-actin binding protein
, neural tissue-specific F-actin-binding protein I
, protein phosphatase 1, regulatory (inhibitor) subunit 9A
, actin-binding protein neurabin
, neurabin 1
, protein phosphatase 1 regulatory subunit 9A