Protein Kinase N1 Proteine (PKN1)

The protein encoded by PKN1 belongs to the protein kinase C superfamily. Zusätzlich bieten wir Ihnen PKN1 Antikörper (38) und PKN1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PKN1 5585 Q16512
PKN1 320795 P70268
Ratte PKN1 PKN1 29355 Q63433
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Top PKN1 Proteine auf antikoerper-online.de

Showing 9 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$860.20
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Insektenzellen Human His-GST   100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$1,502.67
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$352.75
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$639.61
Details

PKN1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , , ,
Mouse (Murine)

Weitere Proteine zu Protein Kinase N1 (PKN1) Interaktionspartnern

Human Protein Kinase N1 (PKN1) Interaktionspartner

  1. Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi (zeige CACNA1A Proteine) kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors.

  2. Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 (zeige PKN2 Proteine) in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer.

  3. PKN1 activity was up-regulated by the active RhoA (zeige RHOA Proteine) mutant (G14V) and suppressed by RhoA (zeige RHOA Proteine) T19N. PKN1 siRNA interrupted the ability of RhoA (zeige RHOA Proteine) to promote ESC proliferation and DNA synthesis. The effect of RhoA (zeige RHOA Proteine) on ESC proliferation is mediated by activation of the PKN1-cyclin D1 (zeige CCND1 Proteine) pathway in vitro.

  4. TXA2 (zeige TBXA2R Proteine)-mediated neoplastic responses in prostate adenocarcinoma PC-3 (zeige PCSK1 Proteine) cells occur through a PRK1/PRK2 (zeige PKN2 Proteine)-dependent mechanism.

  5. Transcriptome and interactome analyses uncover that PRK1 regulates expression of migration-relevant genes by interacting with the scaffold protein (zeige HOMER1 Proteine) sperm-associated antigen 9 (SPAG9/JIP4 (zeige SPAG9 Proteine)).

  6. Data indicate that Salmonella SspH1 catalyzes the ubiquitination and proteasome-dependent degradation of PKN1 in cells.

  7. Protein kinase N1 inhibits Wnt/b-catenin signaling and apoptosis in melanoma cells.

  8. Protein kinase N1 is a novel substrate of NFATc1 (zeige NFATC1 Proteine)-mediated cyclin D1 (zeige CCND1 Proteine)-CDK6 (zeige CDK6 Proteine) activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.

  9. PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It

  10. Data show that just one contact site as being relevant for binding of RhoA (zeige RHOA Proteine) and domain from PRK1, and the HR1b domain was found not to contribute to RhoA (zeige RHOA Proteine) binding.

Mouse (Murine) Protein Kinase N1 (PKN1) Interaktionspartner

  1. In mice, phosphorylation-regulated (zeige PHAX Proteine) neutrophil polarization mechanism is driven by PKN1-mediated phosphorylation of a newly identified RAB21 (zeige RAB21 Proteine) effector RPH3A (zeige RPH3A Proteine).

  2. Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 (zeige PKN2 Proteine) in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer.

  3. Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 and PRK2 (zeige PKN2 Proteine) to negatively regulate pyrin (zeige MEFV Proteine) by phosphorylation.

  4. Protein kinase N1, a cell inhibitor of Akt (zeige AKT1 Proteine) kinase, has a central role in quality control of germinal center formation

  5. PKN is activated by ischemia/reperfusion and inhibits apoptosis of cardiac myocytes, thereby protecting the heart from I/R injury.

  6. Leishmania mexicana infectivity is associated with differential expression of protein kinase C-like triggered during a cell-cell contact

  7. Pkn1 is involved in ganglioside signals that regulate TNF-alpha (zeige TNF Proteine) signaling and synthesis.

Fruit Fly (Drosophila melanogaster) Protein Kinase N1 (PKN1) Interaktionspartner

  1. polarity-induced spatiotemporal control of Rok (zeige ROCK1 Proteine) and Pkn is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.

  2. The delorean phenotype, with its associated defects in wing morphology, provides evidence of a role for PKN in adult morphogenetic processes.

  3. Drosophila protein kinase N is a negative regulator of actin-myosin activity during oogenesis.

  4. identified a requirement for Pkn in wing morphogenesis, thereby revealing the first postembryonic function for Pkn

PKN1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Genbezeichner und Symbole assoziert mit Protein Kinase N1 Proteine (PKN1)

  • protein kinase N1 (PKN1)
  • protein kinase N1 (Pkn1)
  • protein kinase N1b (pkn1b)
  • protein kinase N1 (pkn1)
  • Protein kinase N (Pkn)
  • 3-2 Protein
  • CG2049 Protein
  • CG2055 Protein
  • CT6637 Protein
  • CT6660 Protein
  • DBK Protein
  • Dmel\\CG2049 Protein
  • dPKN Protein
  • F730027O18Rik Protein
  • l(2)06736 Protein
  • l(2)45Ca Protein
  • PAK-1 Protein
  • PAK1 Protein
  • Pk45C Protein
  • Pk?3 Protein
  • Pkn Protein
  • PKN-ALPHA Protein
  • PKN1 Protein
  • PRK1 Protein
  • PRK2 Protein
  • Prkcl1 Protein
  • Stk3 Protein
  • v(2)rG232 Protein

Bezeichner auf Proteinebene für Protein Kinase N1 Proteine (PKN1)

protease-activated kinase 1 , protein kinase C-like 1 , protein kinase C-like PKN , protein kinase C-related kinase 1 , protein kinase PKN-alpha , protein-kinase C-related kinase 1 , serine-threonine kinase N , serine-threonine protein kinase N , serine/threonine protein kinase N , serine/threonine-protein kinase N1 , serine/threonine kinase 3 , protein kinase N1 , serine/threonine-protein kinase N1-like , protein kinase PKN , CG2049-PB , CG2049-PC , CG2049-PD , CG2049-PE , CG2049-PF , CG2049-PG , CG2049-PH , CG2049-PI , CG2049-PJ , CG2049-PK , CG2049-PL , CG2049-PM , Pkn-PB , Pkn-PC , Pkn-PD , Pkn-PE , Pkn-PF , Pkn-PG , Pkn-PH , Pkn-PI , Pkn-PJ , Pkn-PK , Pkn-PL , Pkn-PM , protein kinase N , protein kinase c related , protein kinase related to protein kinase N , protein kinase-like 45C

GENE ID SPEZIES
5585 Homo sapiens
320795 Mus musculus
455785 Pan troglodytes
509080 Bos taurus
100007897 Danio rerio
100379847 Xenopus (Silurana) tropicalis
100401855 Callithrix jacchus
29355 Rattus norvegicus
35950 Drosophila melanogaster
100713234 Cavia porcellus
101118101 Ovis aries
100856398 Canis lupus familiaris
100515528 Sus scrofa
Ausgewählte Anbieter für PKN1 Proteine (PKN1)
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