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Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). Zusätzlich bieten wir Ihnen Protein Geranylgeranyltransferase Type I, beta Subunit Antikörper (37) und viele weitere Produktgruppen zu diesem Protein an.
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our study showed, for the first time, that HIF-1alpha was regulated by protein prenylation transferase GGTI and mediated the effect of GGTI on glioma cell migration and invasion
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
RNAi knockdown of GGTase-Ibeta inhibited invasion, disrupted F-actin organization and decreased the level of cofilin in PC-3 cells.
results suggest that geranylgeranylation of RhoA is critical for cancer cell invasion
Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
The results showed that the magnitude of long-term potentiation (LTP) was markedly suppressed in hippocampal slices from GGT-haplodeficient mice. Consistent with the synaptic dysfunction, there was a significant decrease in cortical spine density and cognitive function in GGT-haplodeficient mice.
This study demonstrated that Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system.
A decrease in membrane-associated Rho proteins in aged brain is associated with down-regulation of GGTase-Ibeta.
Targeting GGTase-I activates RHOA and leads to increased macrophage reverse cholesterol transport and reduced atherosclerosis development despite a significant increase in inflammation.
deficiencies in either FTase or GGTase-I lead to severe hepatocellular disease. Our studies lay to rest the earlier notion that FTase is dispensable in adult tissues
Data show that mice lacking GGTase-I in macrophages develop severe joint inflammation resembling erosive rheumatoid arthritis.
Both Fntb and Pggt1b are required for the homeostasis of skin keratinocytes.
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994
protein geranylgeranyltransferase type I, beta subunit
, geranylgeranyl transferase type I subunit beta
, geranylgeranyl transferase type-1 subunit beta
, geranylgeranyltransferase type I beta subunit
, type I protein geranyl-geranyltransferase subunit beta
, geranylgeranyltransferase type 1 beta
, geranylgeranyltransferase type I (GGTase-I)