Proline-serine-threonine Phosphatase Interacting Protein 1 Proteine (PSTPIP1)

The protein encoded by PSTPIP1 binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. Zusätzlich bieten wir Ihnen PSTPIP1 Antikörper (48) und PSTPIP1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PSTPIP1 9051 O43586
PSTPIP1 19200 P97814
Ratte PSTPIP1 PSTPIP1 300732  
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Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$400.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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PSTPIP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) Interaktionspartnern

Human Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) Interaktionspartner

  1. We identified HPIP protein expression as a novel independent poor prognostic indicator in cervical cancer

  2. Case Report: classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA (zeige PAPPA Proteine)) syndrome with E250K mutation of PSTPIP1.

  3. HPIP expression is associated with high-grade ovarian tumors.

  4. we demonstrated that HPIP silencing suppressed TGF-beta1 (zeige TGFB1 Proteine)-induced EMT (zeige ITK Proteine) in lung cancer cells by inhibiting Smad2 (zeige SMAD2 Proteine) activation.

  5. our study demonstrated that knockdown of HPIP significantly inhibits the proliferation and migration/invasion of HNSCC cells by suppressing the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway.

  6. these structural variations in CD2BP1 gene due to the mutations could be one of the strongest reasons to demonstrate the involvement of these gene variations in the patients with rheumatoid arthritis.

  7. PSTPIP1 was found to interact with pyrin (zeige MEFV Proteine) at the leading edge during cell migration.

  8. Molecular interactions between HPIP and FAK (zeige PTK2 Proteine), and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics.

  9. Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA (zeige PAPPA Proteine) syndrome.

  10. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors.

Mouse (Murine) Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) Interaktionspartner

  1. a new PSTPIP1/PTPN6 (zeige PTPN6 Proteine)/SHIP1 (zeige INPP5D Proteine)/2-dependent negative feedback mechanism that counterbalances Src (zeige SRC Proteine) and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption

  2. analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA (zeige PAPPA Proteine)) Syndrome-associated PSTPIP1 A230T mutant proteins

  3. the intracellular Fas ligand (FasL (zeige FASL Proteine)) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL (zeige FASL Proteine)

  4. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration

PSTPIP1 Protein Überblick

Protein Überblick

The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.

Genbezeichner und Symbole assoziert mit PSTPIP1

  • proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1)
  • proline-serine-threonine phosphatase interacting protein 1 S homeolog (pstpip1.S)
  • proline-serine-threonine phosphatase interacting protein 1 (pstpip1)
  • proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1)
  • CD2BP1 Protein
  • CD2BP1L Protein
  • CD2BP1S Protein
  • def-2 Protein
  • H-PIP Protein
  • PAPAS Protein
  • PSTPIP Protein
  • PSTPIP1 Protein

Bezeichner auf Proteinebene für PSTPIP1

proline-serine-threonine phosphatase interacting protein 1 , proline-serine-threonine phosphatase-interacting protein 1 , CD2 antigen-binding protein 1 , CD2 cytoplasmic tail-binding protein , CD2-binding protein 1 , PEST phosphatase-interacting protein 1

GENE ID SPEZIES
415349 Gallus gallus
447609 Xenopus laevis
513924 Bos taurus
100050881 Equus caballus
100152628 Sus scrofa
100379705 Xenopus (Silurana) tropicalis
9051 Homo sapiens
19200 Mus musculus
300732 Rattus norvegicus
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