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PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Zusätzlich bieten wir Ihnen PDCD4 Antikörper (256) und PDCD4 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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In the high malignant group the PDCD4 mRNA and PDCD5 (zeige PDCD5 Proteine) mRNA expressions were significantly decreased compared with the low malignant group and the control group. PDCD4 mRNA and PDCD5 (zeige PDCD5 Proteine) mRNA expressions are promising targets for the diagnosis and treatment of glioma.
miR (zeige MLXIP Proteine)-21 may promote salivary adenoid cystic carcinoma progression via PDCD4 and PTEN down-regulation and Bcl-2 (zeige BCL2 Proteine) up-regulation.
The expression of PDCD4 is decreased in cervical cancer tissues, compared to miR (zeige MLXIP Proteine)-150 which is increased.
Our study demonstrated that lncRNA-XIST, which acts as a miRNA sponge, impedes miR (zeige MLXIP Proteine)-21-5p to maintain the expression of PDCD4, which contributes to the progression of osteosarcoma (OS). Our findings suggest that the newly identified XIST/miR (zeige MLXIP Proteine)-21-5p/PDCD4 axis could be a potential biomarker or therapeutic target for OS.
miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.
Results found PDCD4 as a target gene of miR (zeige MLXIP Proteine)-93 and miR (zeige MLXIP Proteine)-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR. The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell invasion and migration induced by miR (zeige MLXIP Proteine)-93, while the knockdown of PDCD4 would promote HCC (zeige FAM126A Proteine) cell migration and invasion via the EMT (zeige ITK Proteine) pathway.
Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.
miR503 promotes tumour growth and invasion by directly targeting PDCD4.
A novel mechanism of Pdcd4 action as a translation inhibitor and tumor suppressor has been proposed.
Taken together, this study highlights an important role for miR (zeige MLXIP Proteine)-23a/b as oncomiRs in gastric cancer through the inhibition of PDCD4 translation. These findings may shed new light on the molecular mechanism of gastric carcinogenesis and provide a new avenue for gastric cancer treatment.
MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR (zeige MLXIP Proteine)-21, which mediates ischemic neuronal death.
In colorectal cancer tissues, the Sin1 (zeige MAPKAP1 Proteine) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (zeige MAPKAP1 Proteine) protein level but not mRNA level in colorectal cancer.
-induced expression of PDCD4 is associated with increased beta cell death.
miR (zeige MLXIP Proteine)-155 not only directly inhibited SOCS1 (zeige SOCS1 Proteine) expression, but also increased the expression of p-STAT (zeige STAT1 Proteine) and PDCD4, as well as the production of proinflammation mediators IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) in atherogenesis
our data suggest that Pdcd4 as a crucial regulator in SGs (zeige SKI Proteine) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.
Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (zeige IL10 Proteine).
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) Pathway.
Study found that miR-16 (zeige GDE1 Proteine) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) pathways.
Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.
PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.
miR (zeige MYLIP Proteine)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha (zeige TNF Proteine) pathway in cardiomyocytes.
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
neoplastic transformation inhibitor protein
, nuclear antigen H731
, programmed cell death protein 4
, protein 197/15a
, protein MA-3
, topoisomerase-inhibitor suppressed protein
, death up-regulated gene protein
, protein I11/6
, programmed cell death 4 (neoplastic transformation inhibitor)
, programmed cell death protein 4-like