Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) Proteine (PDCD4)

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Zusätzlich bieten wir Ihnen PDCD4 Antikörper (258) und PDCD4 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human Unkonjugiert Figure annotation denotes ug of protein loaded and % gel used. 100 μg Anmelden zum Anzeigen 9 bis 11 Tage
$364.64
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Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,314.67
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,322.00
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Hefe Orang-Utan His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,322.00
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Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
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Escherichia coli (E. coli) Human Unkonjugiert   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$6,867.69
Details

PDCD4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartnern

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. miR-93 may function as an oncogenic factor in hepatocellular carcinoma, and promotes HCC cell proliferation by targeting PDCD4

  2. These results suggested a correlation between miR421 and PDCD4, and physiological functions of breast cancer cells.

  3. PDCD4-AS1 lncRNA positively regulates the expression and activity of the tumor suppressor PDCD4 in mammary epithelial cells. Both PDCD4-AS1 and PDCD4 show reduced expression in triple negative breast cancer cell lines and in patients, and depletion of PDCD4-AS1 compromised the cellular levels and activity of PDCD4.

  4. miR-21 and PDCD4 might be potential biomarkers of tumor progression and indicators of prognosis of stag II esophageal carcinoma.

  5. Low PDCD4 expression is associated with Drug Resistance in Pancreatic Cancer.

  6. Study established that upregulation of miR-96 in glioblastoma multiforme (GBM) cells confers radioresistance via targeting PDCD4, which might be a potential therapeutic target for GBM.

  7. This study revealed a dynamic regulatory relationship between PDCD4 and critical factors for EMT, establishing a broad, functional role for PDCD4 in laryngeal carcinoma, which may be propagated by the STAT3-miR-21 pathway.

  8. the localization of Pdcd4 to the cytoplasm may be responsible for the suppression of the target mRNA translation and apoptosis.

  9. PDCD4 and PTEN were the functional targets of miR-21.

  10. Various studies support evidence that PDCD4, is a novel tumor suppressor gene, and is downregulated or even absent in colorectal cancer (CRC) and suppresses CRC deterioration. [review]

  11. In the high malignant group the PDCD4 mRNA and PDCD5 mRNA expressions were significantly decreased compared with the low malignant group and the control group. PDCD4 mRNA and PDCD5 mRNA expressions are promising targets for the diagnosis and treatment of glioma.

  12. miR-21 may promote salivary adenoid cystic carcinoma progression via PDCD4 and PTEN down-regulation and Bcl-2 up-regulation.

  13. The expression of PDCD4 is decreased in cervical cancer tissues, compared to miR-150 which is increased.

  14. Our study demonstrated that lncRNA-XIST, which acts as a miRNA sponge, impedes miR-21-5p to maintain the expression of PDCD4, which contributes to the progression of osteosarcoma (OS). Our findings suggest that the newly identified XIST/miR-21-5p/PDCD4 axis could be a potential biomarker or therapeutic target for OS.

  15. miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.

  16. Results found PDCD4 as a target gene of miR-93 and miR-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR. The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC) cell invasion and migration induced by miR-93, while the knockdown of PDCD4 would promote HCC cell migration and invasion via the EMT pathway.

  17. Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.

  18. miR503 promotes tumour growth and invasion by directly targeting PDCD4.

  19. A novel mechanism of Pdcd4 action as a translation inhibitor and tumor suppressor has been proposed.

  20. Taken together, this study highlights an important role for miR-23a/b as oncomiRs in gastric cancer through the inhibition of PDCD4 translation. These findings may shed new light on the molecular mechanism of gastric carcinogenesis and provide a new avenue for gastric cancer treatment.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. These skeletal effects were attributed to inhibition of bone resorption and osteoclast function by miR-21 deficiency through miR-21 targeting programmed cell death 4 (PDCD4), despite the existence of RANKL. As far as we know, this is the first in vivo evidence of a pro-osteoclastic microRNA.

  2. MEG3 functions as a competing endogenous RNAs (ceRNAs) and competes with PDCD4 mRNA for directly binding to miR-21, which mediates ischemic neuronal death.

  3. In colorectal cancer tissues, the Sin1 protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 protein level but not mRNA level in colorectal cancer.

  4. -induced expression of PDCD4 is associated with increased beta cell death.

  5. miR-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT and PDCD4, as well as the production of proinflammation mediators IL-6 and TNF-alpha in atherogenesis

  6. our data suggest that Pdcd4 as a crucial regulator in SGs induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  7. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10.

  8. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway.

  9. Study found that miR-16 was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB and MAPK pathways.

  10. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  11. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  12. In conclusion, miR-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

  13. atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells

  14. we demonstrate that miR-21 regulates T-cell acute lymphoblastic leukemia cell survival via repression of the tumor suppressor Pdcd4.

  15. Dual expression of shAkt1 and Pdcd4 effectively suppresses lung tumorigenesis

  16. miR-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3/8 fragments in the condition of renal IRI

  17. sulforaphane protects PDCD4 downregulation posed by pro-inflammatory stimuli through modulating both transcription and proteolysis via controlling Akt1 and/or S6K1 activities in RAW 264.7 cells

  18. these findings support the existence of a microRNA-21-responsive PDCD4/caspase-3 pathway in the pulmonary tissues that when active serves to promote endothelial apoptosis in vitro and pulmonary hypertension in vivo.

  19. we demonstrated that the miR-21-PDCD4 signaling was involved in the cellular responses to UVB in a mouse epidermal cell line

  20. during bacterial pneumonia IFNlambda promotes inflammation by inhibiting miR-21 regulation of PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB/ TNF-alpha pathway in cardiomyocytes.

PDCD4 Protein Überblick

Protein Überblick

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit PDCD4

  • programmed cell death 4 (PDCD4)
  • programmed cell death 4 (Pdcd4)
  • programmed cell death 4b (pdcd4b)
  • programmed cell death 4 L homeolog (pdcd4.L)
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4)
  • programmed cell death 4 (pdcd4)
  • cb45 Protein
  • D19Ucla1 Protein
  • Dug Protein
  • h731 Protein
  • Ma3 Protein
  • MGC69337 Protein
  • PDCD4 Protein
  • sb:cb45 Protein
  • Tis Protein
  • wu:fc84b08 Protein

Bezeichner auf Proteinebene für PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPEZIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
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