Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) Proteine (PDCD4)

PDCD4 is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Zusätzlich bieten wir Ihnen PDCD4 Antikörper (259) und PDCD4 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PDCD4 27250 Q53EL6
PDCD4 18569 Q61823
PDCD4 64031 Q9JID1
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Showing 10 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human Unkonjugiert Figure annotation denotes ug of protein loaded and % gel used. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
$364.64
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,314.67
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,322.00
Details
Hefe Orang-Utan His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,322.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$5,723.08
Details

PDCD4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartnern

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. miR206 promoted the onset of SANFH by inducing apoptosis and suppressed the proliferation of osteoblasts, which was dependent on the inhibition of PDCD4.

  2. Results found PDCD4 as a target gene of miR (zeige MLXIP Proteine)-93 and miR (zeige MLXIP Proteine)-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR. The re-expression of PDCD4 could attenuate the hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell invasion and migration induced by miR (zeige MLXIP Proteine)-93, while the knockdown of PDCD4 would promote HCC (zeige FAM126A Proteine) cell migration and invasion via the EMT (zeige ITK Proteine) pathway.

  3. Reduced expression of PDCD4 was found in decidual and chorionic tissues, and peripheral blood mononuclear cells from patients with missed abortion.

  4. miR503 promotes tumour growth and invasion by directly targeting PDCD4.

  5. A novel mechanism of Pdcd4 action as a translation inhibitor and tumor suppressor has been proposed.

  6. Taken together, this study highlights an important role for miR (zeige MLXIP Proteine)-23a/b as oncomiRs in gastric cancer through the inhibition of PDCD4 translation. These findings may shed new light on the molecular mechanism of gastric carcinogenesis and provide a new avenue for gastric cancer treatment.

  7. lncRNA CASC9 functions as an oncogene (zeige RAB1A Proteine) by negatively regulating PDCD4 expression through recruiting EZH2 (zeige EZH2 Proteine) and subsequently altering H3K27me3 level. Our study implicates lncRNA CASC9 as a valuable biomarker for ESCC diagnosis and prognosis.

  8. Exosomes derived from cisplatin-resistant OSCC cells transferred miR (zeige MLXIP Proteine)-21 to oral squamous cell carcinoma (OSCC) parental cells and induced cisplatin resistance by targeting phosphatase and tensin homolog (PTEN) and programmed cell death 4 (PDCD4).

  9. These results indicate that the ROS (zeige ROS1 Proteine)-STAT3 (zeige STAT3 Proteine)-miR (zeige MLXIP Proteine)-21-PDCD4 signaling axis plays an important role in arsenic -induced carcinogenesis.

  10. PDCD4 is expressed in the cytoplasm of glandular epithelium of control endometrium and varied during the cycle changes of endometrium. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic or ectopic endometrium. There was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. In colorectal cancer tissues, the Sin1 (zeige MAPKAP1 Proteine) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (zeige MAPKAP1 Proteine) protein level but not mRNA level in colorectal cancer.

  2. -induced expression of PDCD4 is associated with increased beta cell death.

  3. miR (zeige MLXIP Proteine)-155 not only directly inhibited SOCS1 (zeige SOCS1 Proteine) expression, but also increased the expression of p-STAT (zeige STAT1 Proteine) and PDCD4, as well as the production of proinflammation mediators IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) in atherogenesis

  4. our data suggest that Pdcd4 as a crucial regulator in SGs (zeige SKI Proteine) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

  5. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (zeige IL10 Proteine).

  6. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) Pathway.

  7. Study found that miR-16 (zeige GDE1 Proteine) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) pathways.

  8. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

  9. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

  10. In conclusion, miR (zeige MLXIP Proteine)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. miR (zeige MYLIP Proteine)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha (zeige TNF Proteine) pathway in cardiomyocytes.

PDCD4 Protein Überblick

Protein Überblick

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit PDCD4

  • programmed cell death 4 (PDCD4)
  • programmed cell death 4 (Pdcd4)
  • programmed cell death 4b (pdcd4b)
  • programmed cell death 4 L homeolog (pdcd4.L)
  • programmed cell death 4 (neoplastic transformation inhibitor) (PDCD4)
  • programmed cell death 4 (pdcd4)
  • cb45 Protein
  • D19Ucla1 Protein
  • Dug Protein
  • h731 Protein
  • Ma3 Protein
  • MGC69337 Protein
  • PDCD4 Protein
  • sb:cb45 Protein
  • Tis Protein
  • wu:fc84b08 Protein

Bezeichner auf Proteinebene für PDCD4

neoplastic transformation inhibitor protein , nuclear antigen H731 , programmed cell death protein 4 , protein 197/15a , protein MA-3 , topoisomerase-inhibitor suppressed protein , death up-regulated gene protein , death-upregulated , protein I11/6 , programmed cell death 4 (neoplastic transformation inhibitor) , programmed cell death protein 4-like

GENE ID SPEZIES
27250 Homo sapiens
18569 Mus musculus
64031 Rattus norvegicus
321061 Danio rerio
380222 Xenopus laevis
506724 Bos taurus
374191 Gallus gallus
407925 Xenopus (Silurana) tropicalis
450735 Pan troglodytes
477818 Canis lupus familiaris
695345 Macaca mulatta
100021762 Monodelphis domestica
100080517 Ornithorhynchus anatinus
100354557 Oryctolagus cuniculus
100413000 Callithrix jacchus
100469480 Ailuropoda melanoleuca
100584426 Nomascus leucogenys
100157112 Sus scrofa
100173014 Pongo abelii
100723476 Cavia porcellus
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