Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) Proteine (PDCD4)

Human Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

1. PDCD4 is expressed in the cytoplasm of glandular epithelium of control endometrium and varied during the cycle changes of endometrium. Compared with the proliferative phase of control endometrium, PDCD4 expression was down-regulated in proliferative phase of eutopic or ectopic endometrium. There was no cyclic variation of PDCD4 expression in eutopic endometrium of adenomyosis patients due to progesterone resistance.

2. Study confirmed that PDCD4 was downregulated in non-small cell lung cancer (NSCLC). PDCD4 is a functional target for miR (zeige MLXIP Proteine)-155 at both transcriptional and post-transcriptional levels.

3. We demonstrated that miR (zeige MLXIP Proteine)-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4.

4. PDCD4 is involved in negative control of stromal fibroblasts conversion into cancer associated fibroblast

5. Results identify PDCD4 as a novel RSK (zeige RPS6KA1 Proteine) substrate. Authors demonstrate that RSK (zeige RPS6KA1 Proteine)-mediated phosphorylation of PDCD4 at S76 promotes PDCD4 degradation.

6. evaluate the relative expression levels of miR (zeige MLXIP Proteine)-196a2 and three of its selected apoptosis-related targets; ANXA1 (zeige ANXA1 Proteine), DFFA (zeige DFFA Proteine) and PDCD4 in a sample of GI cancer patients

7. In colorectal cancer tissues, the Sin1 (zeige MAPKAP1 Proteine) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (zeige MAPKAP1 Proteine) protein level but not mRNA level in colorectal cancer.

8. miRNA-96 is significantly overexpressed in glioma tissues. Moreover, miRNA-96 plays a critical role in apoptosis by inhibiting the expression of PDCD4 in glioma.

9. Supporting the clinical relevance of our results, we found an inverse correlation between ErbB-2 (zeige ERBB2 Proteine)/Stat3 (zeige STAT3 Proteine) nuclear co-expression and PDCD4 expression in ErbB-2 (zeige ERBB2 Proteine)-positive primary invasive breast cancer

10. this study highlights an oncomiR role for miR (zeige MLXIP Proteine)-181b in regulating PDCD4 in colorectal cancer and suggests that miR (zeige MLXIP Proteine)-181b may be a novel molecular therapeutic target for colorectal cancer.

Mouse (Murine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

1. In colorectal cancer tissues, the Sin1 (zeige MAPKAP1 Proteine) protein but not mRNA was significantly upregulated while Pdcd4 protein was downregulated, suggesting that loss of Pdcd4 might correlate with Sin1 (zeige MAPKAP1 Proteine) protein level but not mRNA level in colorectal cancer.

2. -induced expression of PDCD4 is associated with increased beta cell death.

3. miR (zeige MLXIP Proteine)-155 not only directly inhibited SOCS1 (zeige SOCS1 Proteine) expression, but also increased the expression of p-STAT (zeige STAT1 Proteine) and PDCD4, as well as the production of proinflammation mediators IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) in atherogenesis

4. our data suggest that Pdcd4 as a crucial regulator in SGs (zeige SKI Proteine) induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases.

5. Pdcd4 deficiency attenuates atherosclerosis in hyperlipidemic mice in part through the upregulation of the anti-inflammatory cytokine IL-10 (zeige IL10 Proteine).

6. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6 (zeige IL6 Proteine)/STAT3 (zeige STAT3 Proteine) Pathway.

7. Study found that miR-16 (zeige GDE1 Proteine) was the direct regulatory element of PDCD4 and played a vital role in atherosclerosis by regulating PDCD4 and the downstream NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) pathways.

8. Pdcd4 produces unfavorable influences on adipose-derived stem cells(ADSC) stemness, which contribute to adipose dysfunction, obesity and metabolic syndromes, thereby proposing Pdcd4 as a potential intervening target for regulating ADSC cells function.

9. PDCD4 serves as an important regulator of keratinocytes proliferation and contact inhibition in vitro.

10. In conclusion, miR (zeige MLXIP Proteine)-21 is sensitive to high-concentration glucose treatment in macrophages, and appears to have a protective effect in macrophage apoptosis induced by high concentrations of glucose via PDCD4.

Zebrafish Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

1. miR (zeige MYLIP Proteine)-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4

Pig (Porcine) Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) (PDCD4) Interaktionspartner

1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4/NF-kappaB (zeige NFKB1 Proteine)/ TNF-alpha (zeige TNF Proteine) pathway in cardiomyocytes.