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The protein encoded by PLOD2 is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. Zusätzlich bieten wir Ihnen PLOD2 Antikörper (40) und PLOD2 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology.
Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis.
Lysyl hydroxylase-2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues.
LH2b (zeige LHX9 ELISA Kits) catalyzes post-translational modification of collagen in collagen matrix formation and mineralization in bone.
analysis of the specific regulation for the expression of LH isoforms as well as for alternative splicing of LH2 during embryogenesis and in different tissues
TIA1 (zeige TIA1 ELISA Kits) and TIAL1 (zeige TIAL1 ELISA Kits) regulate the alternate splicing of lysyl hydroxylase 2
Hypoxia upregulated PLOD2 protein in U87 and U251 human glioma cell lines.
This study reports for the first time the expression of PLOD2 in Brain Arteriovenous Malformations and suggests a potential role of PLOD2 in brain Arteriovenous Malformations pathophysiology.
FKBP65 (zeige FKBP10 ELISA Kits) is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2.
PLOD2, which is associated with the stiffness of the extracellular matrix, was directly regulated by miR (zeige MLXIP ELISA Kits)-26a-5p and miR (zeige MLXIP ELISA Kits)-26b-5p and may be a good prognostic marker in patients with BC
Results show that miR (zeige MLXIP ELISA Kits)-26a and miR (zeige MLXIP ELISA Kits)-26b were significantly downregulated in renal cell carcinoma clinical specimens and appeared to function as tumor suppressors through regulation of collagen cross-linking enzymes, LOXL2 (zeige LOXL2 ELISA Kits) and PLOD2, both of which function as oncogenes in this disease.
findings reveal that TGFbeta1 (zeige TGFB1 ELISA Kits) induces a SP1 (zeige PSG1 ELISA Kits)- and SMAD3 (zeige SMAD3 ELISA Kits)-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 (zeige TGFB1 ELISA Kits) downstream co-activators and epigenetic modifications
LH2 enhances the metastatic properties of tumor cells and functions as a regulatory switch that controls the relative abundance of biochemically distinct types of collagen cross-links in the tumor stroma.
TGFbeta (zeige TGFB1 ELISA Kits) induced PLOD2/LH2 expression in human synovial osteoarthritic fibroblasts through ALK5 (zeige TGFBR1 ELISA Kits) signaling.
data indicate that HIF-1alpha (zeige HIF1A ELISA Kits) controls sarcoma metastasis through PLOD2-dependent collagen modification and organization in primary tumors
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
lysyl hydroxylase 2
, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
, Procollagen-lysine 2-oxoglutarate 5-dioxygenase (Lysine hydroxylase) 2
, Procollagen-lysine, 2-oxoglutarate 5-dioxygenase (Lysine hydroxylase) 2
, lysine hydroxylase 2
, lysyl hydroxlase 2
, telopeptide lysyl hydroxylase
, procollagen-lysine 2-oxoglutarate 5-dioxygenase 2