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SF3B14 encodes a 14 kDa protein subunit of the splicing factor 3b complex.
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Cow (Bovine) Polyclonal SF3B14 Primary Antibody für WB - ABIN2779092
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Sf3b14 is required for the blastocyst formation.
the p14-RNA interaction screens charges on the backbone of the branch site during spliceosome assembly.
determined the high resolution structure of a complex between SF3b14 and a peptide derived from SF3b155 (zeige SF3B1 Antikörper) and proposed a model for recognition of the pre-mRNA branch sequence adenosine.
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.
uncharacterized protein LOC100365504
, SF3B 14 kDa subunit
, pre-mRNA branch site protein p14
, SF3b 14 kDa subunit
, spliceosome-associated protein, 14 kDa subunit