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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Zusätzlich bieten wir Ihnen Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 1 Antikörper (76) und viele weitere Produktgruppen zu diesem Protein an.
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Expression of the Kv4.1-targeted shRNA significantly decreased interspike intervals and increased repetitive firing rates in suprachiasmatic nucleus (SCN) neurons during the day and at night. results presented here also revealed that the acute knockdown of Kv4.1 had differential effects on the daytime and nighttime input resistance and repetitive firing rates in SCN neurons.
The complex voltage-dependent gating rearrangements of eukaryotic Kv channels are not limited to the membrane-spanning core but must include the intracellular T1-T1 interface.
S-glutathionylation of an auxiliary subunit confers redox sensitivity to Kv4 channel inactivation.
reflected in the immunoblotting data KV4.1 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy.
These results demonstrated that Kv4.1 plays a role in proliferation of tumorigenic human mammary epithelial cells.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.
, potassium voltage gated channel, Shal-related family, member 1
, potassium voltage-gated channel subfamily D member 1
, voltage-gated potassium channel subunit Kv4.1
, Shal-type potassium channel
, potassium voltage gated channel Shal-related family member 1
, potassium voltage-gated channel, Shal-related family, member 1
, voltage-gated shal-type potassium channel member 1
, potassium channel alpha subunit Kv4.1