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Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal POLQ Primary Antibody für ICC, IF - ABIN450054
Kawamura, Bahar, Seimiya, Chiyo, Wada, Okada, Hatano, Tokuhisa, Kimura, Watanabe, Honda, Sakiyama, Tagawa, O-Wang: DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers. in International journal of cancer 2004
Our results indicate that there is a synthetic lethal relationship between pol theta;-mediated DNA repair and homologous recombination pathways
Data suggest that error-free DNA replication through 3-deaza-3-methyladenine adduct is mediated via three different pathways dependent upon POL-iota/POL-kappa, POL-theta, and POL-zeta.
Use fluorescence resonance energy transfer to monitor assembly of the human replicative polymerase holoenzyme.
These results suggest that variants in the POLQ gene may be associated with the risk of Luminal breast cancer
A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients.
Polymerase theta; uses a specialized thumb subdomain to establish unique upstream contacts to the primer DNA strand.
depletion of Poltheta; has a synergistic effect on cell survival in the absence of BRCA genes, suggesting that the inhibition of this mutagenic polymerase (zeige RAD51 Antikörper) represents a valid therapeutic avenue for tumours carrying mutations in homology-directed repair genes
results reveal a synthetic lethal relationship between the homol (zeige FANCD2 Antikörper)ogous-recombination pathway and Poltheta;-mediated repair in epithelial ovarian cancers, and identify Poltheta; as a novel druggable target for cancer therapy
A role for DNA polymerase theta; in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.
POLQ possesses a DNA polymerase (zeige POLB Antikörper) activity that appears to be template independent and allows efficient extension of single-stranded DNA as well as duplex DNA with either protruding or multiply mismatched 3'-OH termini.
Poltheta;-helicase promotes chromosomal translocations by alternative nonhomologous end joining in mouse embryonic stem cells and also suppresses CRISPR-Cas9- mediated gene targeting by homologous recombination. Poltheta;-helicase activity facilitates the removal of RPA from resected double-strand breaks to allow their annealing and subsequent joining by alternative nonhomologous end joining.
Classical non-homologous end-joining (cNHEJ) and polymerase theta-mediated end-joining (TMEJ) act both parallel and redundant in mouse embryonic stem cells and account for virtually all end-joining activity.
Here, the authors discover that mammalian Poltheta; transfers nucleotides to the 3' terminus of DNA during alt (zeige ALT Antikörper)-EJ in vitro and in vivo by oscillating between three different modes of terminal transferase (zeige DNTT Antikörper) activity: non-templated extension, templated extension in cis (zeige CISH Antikörper), and templated extension in trans.
DNA polymerase theta mediates end joining repair of chromosome breaks and helps to sustain cell viability and genome stability by rescuing chromosome break repair when resection is misregulated or NHEJ is compromised.
A role for POLQ in an alternative end joining pathway that suppresses the formation of chromosomal translocations.
loss of Polq in mice results in increased rates of homology-directed repair, evident by recombination of dysfunctional telomeres and accumulation of RAD51 (zeige RAD51 Antikörper) at double-stranded breaks
genetic inactivation of an homologous-recombination gene (Fancd2 (zeige FANCD2 Antikörper)) and Polq in mice results in embryonic lethality
the polymerase and other functional domains of POLQ both play important roles in tolerance to etoposide and gamma-irradiation.
DNA Pol theta has a specialized function in lymphocytes and in tumor progression
Polq has a role in maintaining genomic integrity, which is probably distinctive from the major homologous recombination pathway regulated by ATM (zeige ATM Antikörper)
Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.
polymerase (DNA directed), theta
, DNA polymerase theta
, DNA polymerase eta