anti-Polymerase (DNA Directed), gamma (POLG) Antikörper

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Zusätzlich bieten wir Ihnen POLG Proteine (12) und POLG Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
POLG 85472 Q9QYV8
POLG 5428 P54098
POLG 18975  
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Top anti-POLG Antikörper auf antikoerper-online.de

Showing 10 out of 58 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Polg Antibody   Titration: 1.0 ug/ml   Positive Control: Rat Lung 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP1-33633] - Paraffin-embedded Skeletal Muscle, using antibody 10 ug/ml. Western Blot: DNA Polymerase gamma Antibody [NBP1-33633] - Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB Western Blot: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. POLG antibody diluted at 1:5000. Immunocytochemistry/Immunofluorescence: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with methanol-fixed HeLa cell at 1:200 dilution. 0.05 mL Anmelden zum Anzeigen 10 bis 13 Tage
$556.31
Details
Human Kaninchen Unkonjugiert ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human skeletal muscle, using DNA polymerase gamma, antibody(10 μg/ml). 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Maus Kaninchen Unkonjugiert FACS, IF, IHC (p), WB POLG Antibody (C-term)  western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). POLG Antibody (C-term)  flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human laryngeal tissue labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$318.45
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HeLa, using DNA polymerase gamma antibody at 1:200 dilution. Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP2-33800] - liver cancer Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP2-33800] - Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details

POLG Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-POLG Antikörper

  1. Human Polyclonal POLG Primary Antibody für ICC, IF - ABIN4305533 : Wu, Li, Zhang, Wu, Huang, Chen: Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine. in Mutation research 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal POLG Primary Antibody für IF (p) - ABIN1696002 : Prasad, Çağlayan, Dai, Nadalutti, Zhao, Gassman, Janoshazi, Stefanick, Horton, Krasich, Longley, Copeland, Griffith, Wilson: DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria. in DNA repair 2017 (PubMed)

  3. Human Polyclonal POLG Primary Antibody für IF (p), IHC (p) - ABIN1714946 : Chen, Zhao, Cai, Sun, Hu, Huang, Kong, Kong: The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. in Redox biology 2017 (PubMed)

  4. Cow (Bovine) Polyclonal POLG Primary Antibody für WB - ABIN2783430 : Mancini, Roncaglia, Brussino, Stevanin, Lo Buono, Krmac, Maltecca, Gazzano, Bartoletti Stella, Calvaruso, Iommarini, Cagnoli, Forlani, Le Ber, Durr, Brice, Ghigo, Casari, Porcelli, Funaro, Gasparre et al.: Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ... in BMC medical genomics 2013 (PubMed)

Weitere Antikörper gegen POLG Interaktionspartner

Human Polymerase (DNA Directed), gamma (POLG) Interaktionspartner

  1. Two tag SNPs of TFAM and POLG were associated with multibacillary leprosy in Han Chinese from Southwest China.

  2. POLG phenotypes and natural history of early-onset POLG-related disorders in a large multinational pediatric cohort

  3. Together with mitochondrial dysfunction in bipolar disorder, the present results suggested deleterious POLG1 variants as a credible risk for the multifactorial disease.

  4. This study suggests that, at variance with mouse and un/de-differentiated human cells, differentiated human cells control mtDNA levels irrespective of POLG methylation.

  5. One patient presented with Leigh syndrome and had a homozygous deletion in the NDUFAF2 gene, while the second patient had a homozygous mutation in the POLG gene, [c.1399G>A; p.Ala467Thr].

  6. The rs758130 in POLG gene was significantly associated with the prognosis of patients in a dose-dependent manner. Moreover, GG genotype in rs1061316 showed significantly high mtDNA content, an indicator of better prognosis.

  7. Pol G composes the mtDNA replication machinery, this replication machinery and failure to repair these mtDNA errors results in mtDNA mutations and as a result mitochondrial dysfunction - a major driving force behind aging and age-related diseases.

  8. POLG mutations are associated with progressive external ophthalmoplegia.

  9. tudies on the impact of mitochondrial DNA variants present conflicting data but highlight POLG as a particularly interesting candidate gene for both male and female infertility.

  10. This review presented that the patient with epilepsy due to homozygous pathogenic variants located in the linker region of POLG were associated with later age of onset and longer survival compared to compound heterozygous variants.

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) Interaktionspartner

  1. Cardiac mitochondrial polymerase gamma dysfunction alters nuclear DNA methylation (zeige HELLS Antikörper).

  2. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  3. POLG's 3'-5' exonuclease (zeige EXOSC10 Antikörper) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  4. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  5. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  6. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  7. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO (zeige C10ORF2 Antikörper) and Alpers syndrome, and the exonuclease (zeige EXO1 Antikörper) deficient pol-gamma (exo (zeige XRN1 Antikörper)(-)) in premature aging mouse models.

  8. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  9. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (zeige EXOSC10 Antikörper) activity is required for preserving mtDNA integrity.

  10. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

POLG Antigen-Profil

Protein Überblick

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Genbezeichner und Symbole assoziert mit POLG

  • polymerase (DNA) gamma, catalytic subunit L homeolog (polg.L) Antikörper
  • DNA polymerase gamma, catalytic subunit (Polg) Antikörper
  • DNA polymerase gamma, catalytic subunit (POLG) Antikörper
  • polymerase (DNA directed), gamma (POLG) Antikörper
  • polymerase (DNA directed), gamma (polg) Antikörper
  • polymerase (DNA directed), gamma (Polg) Antikörper
  • AA409516 Antikörper
  • MDP1 Antikörper
  • MIRAS Antikörper
  • MTDPS4A Antikörper
  • MTDPS4B Antikörper
  • PEO Antikörper
  • POLG Antikörper
  • POLG1 Antikörper
  • PolgA Antikörper
  • SANDO Antikörper
  • SCAE Antikörper

Bezeichner auf Proteinebene für POLG

DNA polymerase gamma , DNA polymerase subunit gamma-1 , DNA-directed DNA polymerase gamma , mitochondrial DNA polymerase catalytic subunit , polG-alpha , polymerase (DNA directed), gamma , DNA polymerase subunit gamma-1-like , PolG-alpha , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polymerase, gamma

GENE ID SPEZIES
397851 Xenopus laevis
85472 Rattus norvegicus
404292 Gallus gallus
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
100150924 Danio rerio
100728907 Cavia porcellus
100157469 Sus scrofa
533090 Bos taurus
Ausgewählte Anbieter für anti-POLG (POLG) Antikörper
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