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PCBP4 encodes a member of the KH-domain protein subfamily.
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PCBP4 plays important roles in the induction of cisplatin resistance in human maxillary cancers.
expression of alpha CP-4 can inhibit proliferation and tumorigenesis of lung cancer cells, both in vivo and in vitro, by delaying the progression of the cell cycle
the p53 (zeige TP53 Proteine)-PCBP4-ZFP871 axis represents a novel feedback loop in the p53 (zeige TP53 Proteine) pathway.
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.
poly(rC) binding protein 4
, poly(rC)-binding protein 4
, poly(rC)-binding protein 4-like
, LYST-interacting protein
, RNA binding protein MCG10