Poly(A) Binding Protein, Cytoplasmic 1 Proteine (PABPC1)

PABPC1 encodes a poly(A) binding protein. Zusätzlich bieten wir Ihnen Poly(A) Binding Protein, Cytoplasmic 1 Antikörper (79) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PABPC1 26986 P11940
PABPC1 18458 P29341
PABPC1 171350 Q9EPH8
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Top Poly(A) Binding Protein, Cytoplasmic 1 Proteine auf antikoerper-online.de

Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,840.83
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Escherichia coli (E. coli) Human Unkonjugiert   250 μg Anmelden zum Anzeigen 2 bis 3 Tage
$777.50
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PABPC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Am meisten referenzierte Poly(A) Binding Protein, Cytoplasmic 1 Proteine

  1. Human PABPC1 Protein expressed in Wheat germ - ABIN1313849 : Massimelli, Majerciak, Kruhlak, Zheng: Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA. in Journal of virology 2012 (PubMed)

Weitere Proteine zu Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Interaktionspartnern

Human Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Interaktionspartner

  1. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 (zeige SIRT1 Proteine) acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

  2. Epstein-Barr Virus protein EB2 first is recruited to the mRNA cap structure in the nucleus and then interacts with the proteins eIF4G and PABP to enhance the initiation step of translation.

  3. These findings identify PABPC1 as a direct regulator of cardiac hypertrophy and define a new paradigm of gene regulation in the heart, where controlled changes in poly(A) tail length influence mRNA translation.

  4. Data suggest that DEAD-box helicase 3 (DDX3X (zeige DDX3X Proteine)) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein (zeige BLZF1 Proteine) 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (zeige DDX3X Proteine) (via gene silencing with the CRISPR-Cas (zeige CSE1L Proteine) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.

  5. Data suggest that hnRNPLL (zeige HNRPLL Proteine) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (zeige HNRPLL Proteine) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (zeige HNRPLL Proteine) = heterogeneous nuclear ribonucleoprotein L-like (zeige HNRPLL Proteine) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  6. PABP enhances the productive binding of the eRF1 (zeige ZFP36L1 Proteine)-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a (zeige GSPT1 Proteine) which itself has an active role in translation termination.

  7. Unr (zeige P2RY4 Proteine) stimulated the binding of PABP1 to mRNA, and that Unr (zeige P2RY4 Proteine) was required for the stable interaction of PABP1 and eIF4G (zeige EIF4G1 Proteine) in cells.

  8. PABPC1 decreased expression in in infertile men with non-obstructive azoospermia

  9. BTG2 (zeige BTG2 Proteine) stimulates mRNA deadenylation via CAF1 (zeige CHAF1B Proteine) activation through interaction with PABPC1. Interaction of BTG2 (zeige BTG2 Proteine) with the first RRM domain of PABPC1 is required for BTG2 (zeige BTG2 Proteine) to control cell proliferation.

  10. PABPC1 is a novel co-regulator of the AR

Mouse (Murine) Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Interaktionspartner

  1. The nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 (zeige SIRT1 Proteine) acts as an energy sensor and negatively regulates poly(A)RNA transport via deacetylating a poly(A)-binding protein, PABP1.

  2. These results suggest that PABP (zeige EBP Proteine) interacts with HuD (zeige ELAVL4 Proteine) in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP (zeige EBP Proteine) is acted upon by PDI (zeige PDIA3 Proteine) resulting in stimulation of insulin (zeige INS Proteine) translation.

  3. These results demonstrate that EPAB is important for oocyte-somatic communication by maintaining transzonal processes and gap junctions at the preantral stage of folliculogenesis.

  4. The authors found that the endogenous Zfp36 (zeige ZFP36 Proteine) directly interacts with the cytoplasmic poly(A)-binding protein. Importantly, this interaction is required for the translational repression of Zfp36 (zeige ZFP36 Proteine)'s target mRNAs in resolving inflammation.

  5. Data suggest that hnRNPLL (zeige HNRPLL Proteine) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (zeige HNRPLL Proteine) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (zeige HNRPLL Proteine) = heterogeneous nuclear ribonucleoprotein L-like (zeige HNRPLL Proteine) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  6. Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.

  7. Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (zeige EGFR Proteine) signaling.

  8. Epab(-/-) oocytes are smaller in size, contain peripheral germinal vesicles, and are loosely associated with cumulus cells

  9. These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB

  10. Epab is dispensable for mouse spermatogenesis and male fertility.

Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Protein Überblick

Protein Überblick

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.

Genbezeichner und Symbole assoziert mit PABPC1

  • poly(A) binding protein cytoplasmic 1 (PABPC1)
  • poly(A) binding protein, cytoplasmic 1 (Pabpc1)
  • poly(A) binding protein, cytoplasmic 1 S homeolog (pabpc1.S)
  • poly(A) binding protein, cytoplasmic 1 (pabpc1)
  • poly(A) binding protein cytoplasmic 1 like (PABPC1L)
  • poly(A) binding protein, cytoplasmic 1 L homeolog (pabpc1.L)
  • poly(A) binding protein, cytoplasmic 1a (pabpc1a)
  • poly(A) binding protein cytoplasmic 1 (Pabpc1)
  • ePAB Protein
  • pab1 Protein
  • pabp Protein
  • pabp1 Protein
  • PABPC1 Protein
  • pabpc2 Protein
  • PabpI Protein
  • Pabpl1 Protein
  • wu:fb16a02 Protein
  • wu:fi19b08 Protein
  • wu:fj12d09 Protein
  • wu:fj61f06 Protein
  • zgc:109879 Protein

Bezeichner auf Proteinebene für PABPC1

poly(A) binding protein, cytoplasmic 2 , polyadenylate-binding protein 1 , PABP-1 , poly A binding protein 1 , poly(A)-binding protein 1 , PABP 1 , PABP 1-A , PABP-1-A , PABP-A , cytoplasmic poly(A)-binding protein 1-A , poly(A)-binding protein 1-A , polyadenylate-binding protein 1-A , xPABP1-A , poly(A) binding protein, cytoplasmic 1 , polyadenylate-binding protein 1-like , PABP 1-B , PABP-1-B , PABP-B , cytoplasmic poly(A)-binding protein 1-B , poly(A)-binding protein 1-B , polyadenylate-binding protein 1-B , xPABP1-B

GENE ID SPEZIES
26986 Homo sapiens
18458 Mus musculus
171350 Rattus norvegicus
379896 Xenopus laevis
448595 Xenopus (Silurana) tropicalis
612751 Canis lupus familiaris
711882 Macaca mulatta
430997 Gallus gallus
282296 Bos taurus
432140 Xenopus laevis
606498 Danio rerio
100727743 Cavia porcellus
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