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Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. Zusätzlich bieten wir Ihnen PLAG1 Antikörper (67) und viele weitere Produktgruppen zu diesem Protein an.
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HRAS (zeige HRAS Proteine) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 and HMGA2 correlates with the presence of TP53 (zeige TP53 Proteine), FBXW7 (zeige FBXW7 Proteine) mutations, or SMARCB1 (zeige SMARCB1 Proteine) deletion.
Plag1 expression is lost in malignant transformation from pleomorphic adenoma to carcinoma ex pleomorphic adenoma.
MiR (zeige MLXIP Proteine)-26a can facilitate occurrence of pituitary tumor and invasiveness, probably via inhibiting PLAG1 expression.
expression of PLAG1 can be considered a valuable diagnostic marker for recurrent pleomorphic adenoma
High PLAG1 expression is associated with pleomorphic adenoma.
The sensitivity (55%) and specificity (75%) of PLAG1 in diagnosing PA in FNAs is relatively modest thus limiting its diagnostic utility.
The Thr34 of PLAG1 is critical for LpMab-10 recognition.
Data indicate that SLIT2 (zeige SLIT3 Proteine), miR (zeige MLXIP Proteine)-218-1, RET (zeige RET Proteine)/PLAG1 and SLIT2 (zeige SLIT3 Proteine)/ROBO1 (zeige ROBO1 Proteine) pathway involved in Hirschsprung's disease.
Altogether, these data suggest that HMGA2 is an upstream activator of PLAG1.
Report illustrates two different tumorigenic pathways implicating PLAG1 in lipoblastoma: amplification through multiple copies of a small marker chromosome derived from chromosome 8, and a paracentric inversion of the long arm of chromosome 8. Review.
Genome-Wide Association Study Reveals the PLAG1 Gene for Knuckle, Biceps and Shank (zeige SHANK2 Proteine) Weight in Simmental Beef Cattle.
This study demonstrates a strong association of early life body weight with pleiomorphic adenoma gene 1 (PLAG1) genotype in Holstein-Friesian dairy calves. Peripubertal body weight and growth rate were also significantly associated with PLAG1 genotype.
Forced expression of PLAG1 under the control of the Pdx1 (zeige PDX1 Proteine) or Ngn3 (zeige NEUROG3 Proteine) promoter in murine pancreas induces different degrees of endocrine hormone imbalances.
Data indicate a plausible Plag1-Egr1 (zeige EGR1 Proteine)-CD44 (zeige CD44 Proteine) regulatory pathway in the T-ICs (zeige DNAI1 Proteine) of pleomorphic adenomas.
Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions
aP2 (zeige TFAP2A Proteine)-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.
Demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas. Inactivation of Igf2 delays tumour development.
Suggest an important role for furin (zeige FURIN Proteine) in PLAG1-induced salivary gland tumorigenesis in mice.
results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt (zeige WNT2 Proteine) signaling
distinct loci exist for growth and fatness in the two populations and identified HMGA1 (zeige HMGA1 Proteine) and PLAG1 as strong candidate genes on SSC7 and SSC4, respectively.
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene.
pleiomorphic adenoma gene 1
, zinc finger protein PLAG1-like
, pleiomorphic adenoma gene 1 protein
, zinc finger protein PLAG1
, COL1A2/PLAG1 fusion
, C2H2 zinc finger protein PLAG1