Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) ELISA Kits

p53/TP53-regulated repressor of Akt/AKT1 signaling. Zusätzlich bieten wir Ihnen PHLDA3 Antikörper (32) und PHLDA3 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
PHLDA3 23612 Q9Y5J5
Anti-Maus PHLDA3 PHLDA3 27280 Q9WV95
Anti-Ratte PHLDA3 PHLDA3 363989 Q5PQT7
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 6.25 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
Details

Weitere ELISA Kits für PHLDA3 Interaktionspartner

Human Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) Interaktionspartner

  1. Low PHLDA3 expression in ESCC may be predictive of tumor recurrence suggesting that Akt (zeige AKT1 ELISA Kits) activation may be a therapeutic target in ESCCs

  2. Results indicate that tumor suppressor PHLDA3-mediated pathway is important in the development of pancreatic neuroendocrine tumors (PanNETs).

  3. findings indicate somatic mutation of PHLDA3 is rare in common cancer types; PHLDA3 expression was lost in 22% of prostate cancers; these results indicate that PHLDA3 are altered in prostate cancers by loss of expression

  4. Study identifies PHLDA3 as a p53 (zeige TP53 ELISA Kits) target gene that encodes a PH domain-only protein and finds that PHLDA3 competes with the PH domain of Akt (zeige AKT1 ELISA Kits) for binding of membrane lipids, inhibiting Akt (zeige AKT1 ELISA Kits) translocation to the cellular membrane and activation.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 3 (PHLDA3) Interaktionspartner

  1. Phlda3 may cause p53 (zeige TP53 ELISA Kits) accumulation through a feedforward pathway, facilitating tubular injury and its urine excretion.

  2. Data indicate that tumor suppressor PHLDA3-deficient mice develop islet hyperplasia.

  3. Ipl (zeige PHLDA2 ELISA Kits) and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (zeige GPRASP1 ELISA Kits).

PHLDA3 Antigen-Profil

Beschreibung des Gens

p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor (By similarity).

Genbezeichner und Symbole assoziert mit PHLDA3

  • pleckstrin homology like domain family A member 3 (PHLDA3) Antikörper
  • pleckstrin homology like domain, family A, member 3 (Phlda3) Antikörper
  • pleckstrin homology-like domain, family A, member 3 (Phlda3) Antikörper
  • pleckstrin homology-like domain, family A, member 3 (phlda3) Antikörper
  • si:dz182n13.5 Antikörper
  • Tih1 Antikörper
  • zgc:92333 Antikörper

Bezeichner auf Proteinebene für PHLDA3

pleckstrin homology-like domain, family A, member 3 , TDAG51/Ipl homolog 1 , pleckstrin homology-like domain family A member 3 , pleckstrin homology-like domain, family A, member 2 , TDAG/lpl homolog 1

GENE ID SPEZIES
457620 Pan troglodytes
23612 Homo sapiens
27280 Mus musculus
363989 Rattus norvegicus
368779 Danio rerio
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