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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Zusätzlich bieten wir Ihnen Plastin 3 Antikörper (61) und Plastin 3 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.
PLS3 mutation plays a role in low turnover osteoporosis pathophysiology.
In this study, the authors found that the actin filament bundling abilities of PLS1 (zeige PLS1 ELISA Kits) and PLS2 (zeige LCP1 ELISA Kits) were similarly sensitive to Ca(2 (zeige CA2 ELISA Kits)+) (pCa50 ~6.4), whereas PLS3 was less sensitive (pCa50 ~5.9).
Patients with PLS3 mutation-related osteoporosis respond to teriparatide treatment.
We show that genes of the classical apoptosis pathway are involved in the smn-1 (zeige SMN1 ELISA Kits)-mediated neuronal death, and that this phenotype can be rescued by the expression of human SMN1 (zeige SMN1 ELISA Kits), indicating a functional conservation between the two orthologs. Finally, we determined that Plastin3/plst-1 genetically interacts with smn-1 (zeige SMN1 ELISA Kits) to prevent degeneration, and that treatment with valproic acid is able to rescue the degenerative phenotype
PLS3 expression does not always modify SMA (zeige SMN1 ELISA Kits) phenotype
findings emphasize the power of genetic modifiers, PLS3 and CORO1C (zeige CORO1C ELISA Kits), to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA (zeige SMN1 ELISA Kits))--and the power of combinatorial therapy based on splice correction of SMN2 (zeige SMN1 ELISA Kits) and endocytosis improvement to efficiently treat SMA (zeige SMN1 ELISA Kits)
PLS3 is a genuine spinal muscular atrophy protective modifier in SMN1 (zeige SMN1 ELISA Kits)-deleted individuals
Measurements of SMN (zeige STMN1 ELISA Kits) and PLS3 transcript and protein levels in induced pluripotent stem cell-derived motor neurons show limited value as Spinal muscular atrophy biomarkers.
High levels of recombinant hPLS3 mRNA were expressed in motor neurons of SMA (zeige SMN1 ELISA Kits) mice and an increased level of PLS3 protein in total spinal cord, yet neither survival nor the fundamental electrophysiological aspects of the neuromuscular junction improved.
results confirm the role of PLS3 mutations in early onset osteoporosis. The mechanism whereby PLS3 affects bone health is unclear, but it may be linked to osteocyte dendrite function and skeletal mechanosensing
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.
, plastin 3 (T isoform)
, T fimbrin
, T plastin
, plastin 3 (T-isoform)
, plastin 3, T