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The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Zusätzlich bieten wir Ihnen PTTG1 Antikörper (76) und PTTG1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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we confirmed the oncogenic function of PTTG1 in BC and demonstrated that PTTG1 is a target of miR (zeige MLXIP Proteine)-146a-3p.
PTTG1 is an independent prognostic factor and acts as an oncogene (zeige RAB1A Proteine) in colorectal cancer
High PTTG1 expression is associated with aggressive meningiomas.
These results indicate PTTG1 may be a valuable biomarker in ovarian cancer to predict sensitivity to saracatinib, and could form the basis of a targeted prospective saracatinib trial for ovarian cancer.
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 (zeige TRIB1 Proteine) and TRb2 (zeige TRIB2 Proteine)-mediated PTTG1 inhibition, counteracting Rb-deficiency-related genomic instability.
Findings indicate that PBF (zeige PTTG1IP Proteine) and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
PTTG-mediated FGF2 (zeige FGF2 Proteine) upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.
All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain, which may mediate the intermolecular recognition between hPTTG1 and MAP3K.
that PTTG1 is a novel downstream target gene of androgen receptor (zeige AR Proteine) and take part in prostate cancer proliferation and metastasis
Knockdown of PTTG1 suppresses the growth and invasion of LAC (zeige LCT Proteine) cells through upregulation of the TGFbeta1 (zeige TGFB1 Proteine)/SMAD3 (zeige SMAD3 Proteine) signaling.
PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis
High PTTG1 expression is associated with pituitary tumor development.
PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.
RasGrf1 (zeige RASGRF1 Proteine) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.
these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.
Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis
PBF (zeige PTTG1IP Proteine) is the first protein to interact with the critical TH transporter MCT8 (zeige MCT8 Proteine) and modulate its function in vivo
CSN3 (zeige CSN3 Proteine) and CSN5 (zeige COPS5 Proteine) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (zeige CCNB1 Proteine) and Securin via APC (zeige APC Proteine)/C.
The genetically deleting Tff3 (zeige TFF3 Proteine) in mice altered down-regulated Pttg1 and up-regulated serpina3n (zeige SERPINA3N Proteine) expression, indicating a potential role of these factors during the development of presbyacusis.
data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function
Pituitary tumor transforming gene 1 (PTTG1), an oncogene (zeige RAB1A Proteine), was the most up-regulated transcript in KLF6 (zeige KLF6 Proteine)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (zeige KLF6 Proteine).
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
pituitary tumor-transforming protein 1
, pituitary tumor-transforming 1
, ESP1-associated protein 1
, pituitary tumor-transforming gene 1 protein
, tumor-transforming protein 1
, Pituitary tumor transforming