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PITX3 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Zusätzlich bieten wir Ihnen Pituitary Homeobox 3 Antikörper (41) und viele weitere Produktgruppen zu diesem Protein an.
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Study showed that PITX3 methylation was significantly methylated in head and neck squamous cell carcinoma (HNSCC) tumor compared to normal adjacent tissue and correlated with lymph node status. These results provide evidence that PITX3 DNA methylation (zeige HELLS Proteine) is an independent prognostic biomarker for overall survival in patients with HNSCC and might aid in the process of risk stratification for individualized treatment.
Study showed that PITX3 and PITX2 (zeige PITX2 Proteine) were hypermethylated in prostate carcinomas (PCa (zeige FLVCR1 Proteine)) and significantly associated with established clinicopathologic parameters characteristic of PCa (zeige FLVCR1 Proteine).
These findings suggest that p.A203fs in PITX3 is the cause of cataracts in the recruited family.
PITX3 variants rs3758549 and rs4919621 are not associated with ET in Chinese Han population.
novel PITX3 mutation c.573del, p.(Ser192Alafs*117), was identified in heterozygous state in a Belgo-Romanian family with a similar phenotype
our data demonstrate that key midbrain dopamine regulators (Nurr1 (zeige NR4A2 Proteine), Pitx3, and Lmx1a (zeige LMX1A Proteine)) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons
Mutations in PITX3 are not a common cause or a risk factor for multisystem atrophy and progressive supranuclear palsy in the Polish population.
Presence of the rs4919621 allele A in PITX3 significantly increases the risk of Parkinson's disease (PD) patients in a Caucasian population, while rs2281983 allele C and rs4919621 allele A were both risk factors in early onset PD.
This study provided that NURR1 (zeige NR4A2 Proteine) and PITX3 gene expression is decreased in the peripheral blood lymphocytes of Chinese patients with Parkinson's disease patients.
novel synonymous SNP in PITX3 gene may contribute to PD risk in the Chinese population.
In Xenopus, pitx3 appears to inhibit the rotation of presomitic cell cohorts and to be necessary to the bilaterally symmetric expression of pitx2 (zeige PITX2 Proteine) in somites.
Microarray-based identification of Pitx3 targets during Xenopus embryogenesis.
expression of Pitx3 in the presumptive lens ectoderm is critical for retina development
in absence of En1 (zeige EN1 Proteine) and Pitx3, only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.
Pitx3 is specifically required for DA-related function and, if impaired, Pitx3 could contribute during the pathogenesis of Parkinson's disease.
the sonic hedgehog (zeige SHH Proteine) signaling pathway is both necessary and sufficient for the induction of ectopic PITX3 expression in chick mesencephalon downstream of WNT9A (zeige WNT9A Proteine)-induced LMX1a (zeige LMX1A Proteine) transcription.
microphthalmos/aphakia inPITX3 nonsense mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and lens fiber proteins.
Pitx3 binds to an evolutionary conserved bicoid-binding site on the 5'-upstream region of Foxe3 (zeige FOXE3 Proteine). Pitx3 binding to 5'-upstream region of Foxe3 (zeige FOXE3 Proteine) increased transcriptional activity significantly in a cell-based reporter assay.
During fetal myogenesis, Pitx2 (zeige PITX2 Proteine)/3 control this redox state through the regulation of Nrf1 (zeige NRF1 Proteine) and of antioxidant pathways.
Pitx3 overexpressing mouse significantly affects the gene expression of midbrain dopamine neurons. Motor coordination and locomotion activities are significantly affected in mice overexpressing Pitx3 mice.
Primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage.
Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 (zeige EN1 Proteine) and Pitx3, interact in dopaminergic subset specification.
a novel link between Pitx3 function and the selective pattern of midbrain dopaminergic neurons cell loss observed in Parkinson's disease.
pitx3 expression in the primordia of the pituitary, lens, olfactory mucosa, and cranial ganglia is modulated by hedgehog (zeige SHH Proteine) and nodal proteins' signaling.
results demonstrate zebrafish pitx3 represents a true ortholog of the human PITX3 gene and the general function of the Pitx3 protein in lens development is conserved between mammals and the teleost fish
Data demonstrate that Foxe3 (zeige FOXE3 Proteine) is necessary for lens development in zebrafish and that foxe3 (zeige FOXE3 Proteine) lies genetically downstream of pitx3 in a zebrafish lens development pathway.
while lmx1b (zeige LMX1B Proteine) paralogues may contribute to the generation of diencephalic dopaminergic precursors. Conversely, knock-down of pitx3 does not specifically affect any diencephalic dopamine cluster
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
pituitary homeobox 3
, homeobox protein PITX3
, paired-like homeodomain transcription factor 3
, homeobox protein PTX3
, homeodomain transcription factor Pitx-3
, Pituitary homeobox 3 (Homeobox protein PITX3)
, bicoid-like homeodomain transcription factor 3
, bicoid-like homeodomain transcription factor Pitx3