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PGK2 is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis.
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Data from studies in transgenic mice suggest that Pgk2 core promoter elements are required to direct demethylation of DNA and reconfiguration of nucleosomes in testis during sexual maturation and spermatogenesis.
These results identify multiple signaling and metabolic defects that are likely contributors to male infertility and the absence of progressive sperm motility seen in mice lacking GAPDHS (zeige GAPDHS Proteine).
PTBP2 (zeige PTBP2 Proteine) is a trans-acting factor that helps to stabilize Pgk2 mRNA in male mouse germ cells.
Data suggest that binding of PBX4 (zeige PBX4 Proteine), plus its coactivator PREP1, is a rate-limiting step leading to the initiation of tissue-specific transcription of the Pgk2 gene.
Pgk2 crystal structures have been solved; the apoenzyme is in the "open" form; that is, the N-terminal domain that can bind 3-phosphoglycerate and the C-terminal domain that binds ATP are too far apart for the substrates to interact.
t-KH-type splicing regulatory protein (zeige KHSRP Proteine) binds directly to a 93-nt sequence (designated the F1 region) of the 3'-UTR of the Pgk2 mRNA and destabilizes Pgk2 mRNA constructs in testis extracts.
This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.
phosphoglycerate kinase autosomal pseudogene
, phosphoglycerate kinase, testis specific
, phosphoglycerate kinase 2
, testis-specific phosphoglycerate kinase
, phosphoglycerate kinase 2-like