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Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Zusätzlich bieten wir Ihnen Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Antikörper (212) und Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.
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These results suggest that Pin1 promotes the progression of the mitotic cell cycle of SSC (zeige CYP11A1 ELISA Kits) in steady-state, which is required for the sperm production from SSCs.
Pin1 silencing in lymphomas retarded disease progression in mice, making Pin1 an attractive therapeutic target in Myc (zeige MYC ELISA Kits)-driven tumors.
Pin1 enhances adipocyte differentiation by regulating the function of PPARgamma (zeige PPARG ELISA Kits).
Pin1 serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau.
Direct delivery of recombinant Pin1 via fibroin nanoparticle encapsulated cationic lipid complex successfully rescued osteoblast differentiation of pin-1 deficient cells.
Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury.
in vivo functional analyses of Pin1 in the GFAP (zeige GFAP ELISA Kits)-tTA;TRE (zeige TREH ELISA Kits)-SmoA1 mouse model of Hedgehog (zeige SHH ELISA Kits)-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival.
Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (zeige INS ELISA Kits); Pin1 interacts with Sik2 (salt-inducible kinase 2 (zeige SIK2 ELISA Kits)) to regulate calcium signaling.
Pin1 knockout in lupus-prone MRL lpr mi (zeige TLR7 ELISA Kits)ce pre (zeige TLR9 ELISA Kits)vents expres (zeige IRAK1 ELISA Kits)sion o (zeige IRF7 ELISA Kits)f lupus phenotype.
By interacting with PSD-95 (zeige DLG4 ELISA Kits), Pin1 dampens PSD-95 (zeige DLG4 ELISA Kits) ability to complex with NMDARs, thus negatively affecting NMDAR (zeige GRIN1 ELISA Kits) signaling and spine morphology.
Pin1 is an essential factor regulating CPEB degradation
Pin1 binding is required for the inactivation of XeWee1B at M phase, presumably causing isomerization of the phospho-TP motif and thereby impairing the function of the Wee (zeige WEE1 ELISA Kits)-box
Pin1 is a fast-acting enzyme which may be utilised by cells to protect the phosphorylation state of Tissue Factor (zeige F3 ELISA Kits) (TF) in activated cells prolonging TF activity and release, and therefore ensuring adequate haemostasis.
statistically significant correlation didn't exist between serum level of PIN1 and the systolic and diastolic blood pressure, between serum level of eNOS (zeige NOS3 ELISA Kits) and diastolic blood pressure in the norm tension Alzheimer's disease patients, between serum levels of PIN1, eNOS (zeige NOS3 ELISA Kits) and systolic blood pressure, and between serum eNOS (zeige NOS3 ELISA Kits) and systolic and diastolic blood pressure in the patients with hypertension.
Studies results suggest that loss of peptidyl-prolyl isomerase (zeige PPI ELISA Kits) (Pin1) activity could lead to the loss of synaptic plasticity in the development of Alzheimer disease.
Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 (zeige P2RY1 ELISA Kits) stabilization.
In this study, we were aimed to investigate whether the cross talk between pin1 and Notch1 (zeige NOTCH1 ELISA Kits) has a role in this event. Our results indicated that the expression level of Pin1 in resistant SKBR3 cells increased by about twofold relative to sensitive SKBR3 cells. Besides, Pin1 inhibition via juglone reduced the extent of proliferation, colony formation and migration capacity of resistant SKBR3 cells
Parallel folding pathways of PIN1 Fip35 WW domain have been explained by infrared spectra and their computer simulations.
High PIN1 expression is associated with stomach neoplasms.
Pin1 is a novel regulator of ATF1 (zeige AFT1 ELISA Kits) at Thr184.
The dynamic basis for signal propagation in Pin1 N-terminal binding domain WW has been described.
The endoplasmic reticulum (ER) stress decreased Pin1 expression through p53 (zeige TP53 ELISA Kits) activation, and this mechanism may be associated with ER stress-induced cell death. These data reported here support the importance of Pin1 as a potential target molecule mediating tumor development.
The data provide the first evidence that Pin 1 expression in the granulosa cells but not the theca cells changes during follicular development, and that FSH (zeige BRD2 ELISA Kits) stimulate the expression of the Pin 1 gene.
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
, rotamase Pin1
, protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
, prolyl isomerase Pin1
, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a
, peptidyl-prolyl cis-trans isomerase Pin1
, prolyl isomerase Pin1 b
, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b
, Pin1-type peptidyl-prolyl cis/trans isomerase
, Rotamase Pin1