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The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity). Zusätzlich bieten wir Ihnen Peptidyl-tRNA Hydrolase 2 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PTRH2 Primary Antibody für WB - ABIN1881706
Fan, Jiang, Suo, Liu, Xu, Ji, Zhang, Yang: Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells. in International journal of oncology 2009
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Human Polyclonal PTRH2 Primary Antibody für ICC, IF - ABIN4348629
Karmali, Brunquell, Tram, Ireland, Ruoslahti, Biliran: Metastasis of tumor cells is enhanced by downregulation of Bit1. in PLoS ONE 2011
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studies indicate Bit1 is an inhibitor of EMT (zeige ITK Antikörper) and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness
These collective findings indicate that loss of Bit1 expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk (zeige EPHB2 Antikörper) activation-induced suppression of E-cadherin (zeige CDH1 Antikörper) expression.
This study reports on five infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD) patients with a different homozygous PTRH2 mutation, broaden the phenotypic spectrum of the disease and differentiate common symptoms and interindividual variability in IMNEPD associated with a unique mutation.
Homozygous mutation in PTRH2 gene causes progressive sensorineural deafness and peripheral neuropathy in three sisters from a consanguineous family.
Bcl-2 (zeige BCL2 Antikörper) expression patterns in various differentiated esophageal squamous cell carcinoma were higher than those in corresponding normal esophageal tissues with no statistical differences ( p > 0.05). Importantly, Bit1 expression was positively correlated with both matrix metalloproteinase 2 (zeige MMP2 Antikörper) and Bcl-2 (zeige BCL2 Antikörper) expression in esophageal squamous cell carcinoma and esophageal adenocarcinoma tissues ( p < 0.05).
Our data establishes a PTRH2 mutation as a n (zeige DMD Antikörper)ovel driver of (zeige DMD Antikörper) congenital muscle degeneration and identifies a potential novel target to treat muscle (zeige DMD Antikörper) myopathies.
Bit1 may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK (zeige PTK2 Antikörper)-paxillin (zeige PXN Antikörper) pathway.
these findings suggest a tumor suppressive role of the caspase-independent anoikis effector Bit1 in lung cancer.
Reduction of the Bit1 level in cytosol, regulated by E2 binding to ESR1 (zeige ESR1 Antikörper), was mainly mediated through PI3K/AKT (zeige AKT1 Antikörper) pathways.
Bit1 plays pivotal roles in the development and progression of ESCC, and its biological functions in ESCC may be closely associated with AIF (zeige AIFM1 Antikörper) and Bcl-2 (zeige BCL2 Antikörper) levels.
Ptrh2 levels were up-regulated in dystrophin (zeige DMD Antikörper) deficient mdx (zeige DMD Antikörper) muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx (zeige DMD Antikörper) muscle and Duchenne muscular dystrophy (zeige DMD Antikörper) patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle
These results support an unanticipated yet essential role for Bit-1 in controlling myogenesis through regulation of Bcl-2 (zeige BCL2 Antikörper).
downregulation of Bit1 specifically potentiated tumor metastasis in vivo
Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway
These studies establish the physiological significance of Bit1 activity and begin to delineate a Bit1 signaling pathway that acts through Erk (zeige EPHB2 Antikörper) regulation.
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity).
peptidyl-tRNA hydrolase 2
, PTH 2
, bcl-2 inhibitor of transcription 1
, peptidyl-tRNA hydrolase 2, mitochondrial
, Bcl-2 inhibitor of transcription