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In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203).
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Human Polyclonal PEG3 Primary Antibody für IF (p), IHC (p) - ABIN735653
Ge, Liang, Luo, Wei, Han, Schatten, Sun, Zhang: Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice. in Reproductive biology and endocrinology : RB&E 2014
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Data suggest that PEG3 is required for TFEB (zeige TFEB Antikörper) induction and nuclear translocation in a VEGFR2 (zeige KDR Antikörper)- and AMPK (zeige PRKAA1 Antikörper)-dependent manner for decorin/decorin (zeige DCN Antikörper) receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB (zeige TFEB Antikörper) = transcription factor EB (zeige TFEB Antikörper); VEGFR2 (zeige KDR Antikörper) = vascular endothelial growth factor receptor-2 (zeige KDR Antikörper); AMPK (zeige PRKAA1 Antikörper) = AMP-activated protein kinase (zeige PRKAA2 Antikörper))
Peg3 transcriptionally modulates BECN1 (zeige BECN1 Antikörper) activity.
Data indicate that a set of cis (zeige CISH Antikörper)-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.
In the current study, the authors have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3.
A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling.
PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies.
The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver.
we have unveiled a mechanism for a secreted proteoglycan (zeige Vcan Antikörper) in inducing Peg3, a master regulator of macroautophagy in endothelial cells
Results show that a five percent increase in DNA methylation (zeige HELLS Antikörper) of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk.
The Peg3 locus may have evolved to an imprinted domain to cope with both parental and sexual conflicts.
PW1-positive cells were highly proliferative in comparison to PW1neg endothelial cells and were able to form colonies when seeded at clonal dilution.
PW1/Peg3 is a reliable marker of the full population of follicle stem cells and reveal a novel CD34 (zeige CD34 Antikörper)- bulge stem-cell population.
Data suggest that the upregulations of Myb (zeige MYB Antikörper) and Peg3 are likely the key anti-cancer events of EGCG in vivo.
Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting, has been demonstrated for Peg3 gene.
Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1 (zeige OPRK1 Antikörper)) and male-specific lethal 3 (Msl3 (zeige MSL3 Antikörper)).
orientation of the Peg3-ICR may play no role in its allele-specific DNA methylation (zeige HELLS Antikörper)
The results indicate that PW1 is a co-regulator of the beta cell cycle and can thus be considered a novel therapeutic target in diabetes.
This study demonstrated the existence of a novel population of resident adult cardiac stem cells expressing PW1(+) and their involvement in fibrotic remodeling after MI.
promoters of Peg3 derive sexually biased and tissue-specific expression patterns
the expression of PEG3 domain genes within the maternal placenta is not significantly affected by the MIMT1Del mutation and alterations in PEG3 domain gene expression on the fetal side
Data show that a 110 kb microdeletion in the maternally imprinted PEG3 domain that results in a loss of paternal MIMT1 expression and causes late term abortion and stillbirth.
Peg3 was seriously demethylated or showed aberrant methylation patterns in four aborted clones.
PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR (zeige WDR20 Antikörper)), but the PEG3-CpG island is the only DMR (zeige WDR20 Antikörper) that is conserved among these three species.
Porcine skeletal muscle-derived PW1(pos)/Pax7 (zeige PAX7 Antikörper)(neg (zeige TMEM131 Antikörper)) interstitial cells are a source of stem/progenitor cells.
The PEG3 gene expression was not affected by day of pregnancy or breed.
For PEG3, pigs expressed the paternal allele in skeletal muscle, liver, spleen, kidney, and uterus, but biallele in heart, lung, fat, stomach, small intestine, and ovary.
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Kruppel-type zinc finger protein
, paternally-expressed gene 3 protein
, zinc finger and SCAN domain-containing protein 24
, granule cell antiserum positive 4
, paternally expressed gene 3
, zinc-finger protein
, paternally expressed 3
, paternally-expressed gene 3 protein-like
, Paternally-expressed gene 3 protein