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PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Zusätzlich bieten wir Ihnen Patatin-Like phospholipase Domain Containing 2 Antikörper (183) und Patatin-Like phospholipase Domain Containing 2 Kits (47) und viele weitere Produktgruppen zu diesem Protein an.
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Human PNPLA2 Protein expressed in Wheat germ - ABIN1315583
Tavian, Missaglia, Redaelli, Pennisi, Invernici, Wessalowski, Maiwald, Arca, Coleman: Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function. in Human molecular genetics 2012
No difference in the genotype frequency of rs7925131 or rs7942159 in PNPLA2 between the normal free fatty acids (FFA) group and the high FFA group in a Chinese Han population.
Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.
Although we found evidence for moderate association between PNPLA2 tagSNPs and anthropometric and metabolic parameters in our cohort, no evidence for association between polymorphisms in the PNPLA2 gene and the presence and severity of non-alcoholic fatty liver disease was identified.
Study reports the derivation of iPSCs from fibroblasts of two Neutral Lipid Storage Disease with Myopathy (NLSDM)patients carrying different ATGL mutations. These iPSCs exhibited defects in neutral lipid metabolism similar to those of NLSDM fibroblasts. NLSDM-iPSCs were able to undergo directed differentiation into cardiomyocytes.
Thus, ATGL in leucocytes may be an important biomarker for the diagnosis of TGCV and our assay may provide insights into pathophysiology and elucidate the underlying mechanism of TGCV and related disorders.
The ATGL gene was frequently deleted in various forms of human cancers and was associated with poor prognosis.
a Snail1 (zeige SNAI1 Proteine)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.
ABHD5 (zeige ABHD5 Proteine) possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.
Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 (zeige ALOX5 Proteine) expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 (zeige PTGR1 Proteine) levels and death of RPE (zeige RPE Proteine) cells undergoing oxidative stress.
Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).
ATGL in brown adipose tissue is not a prerequisite for cold-induced thermogenesis in vivo.
this study shows that long non-coding steroid receptor (zeige ESR2 Proteine) RNA activator promotes hepatic steatosis through repressing the expression of ATGL
ATGL deficiency results in male infertility in mice.
Loss of ATGL induces spontaneous development of pulmonary neoplasia in knockout mouse model.
ATGL acts as an important upstream signaling node that, via SIRT1 (zeige SIRT1 Proteine), increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism.
CGI-58 (zeige ABHD5 Proteine) regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.
Enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles which is HSL (zeige LIPE Proteine)/ATGL-independent.
The Atgl is down-regulated by the basal transcription factor Sp1 (zeige SP1 Proteine) in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 (zeige SP1 Proteine) and peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Proteine)).
Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.
Results identified functional polymorphisms providing new evidence of PNPLA2 as an important candidate gene for fat deposition and carcass traits in pigs.
Resveratrol activated sirtuin 1 (Sirt1 (zeige SIRT1 Proteine)) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (zeige SIRT1 Proteine) regulation pattern for PPARgamma (zeige PPARG Proteine) to that of ATGL in adipocytes.
analysis of porcine adipose triglyceride lipase (PNPLA2) gene
JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) and MAPK (zeige MAPK1 Proteine) signaling pathways, as well as PPAR gamma (zeige PPARG Proteine) all played important roles in the ATGL expression mediated by leptin (zeige LEP Proteine)
patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.
ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.
the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.
, adipose triglyceride lipase
, calcium-independent phospholipase A2
, patatin-like phospholipase domain containing protein 2
, patatin-like phospholipase domain-containing protein 2
, pigment epithelium-derived factor
, transport-secretion protein 2.2
, triglyceride hydrolase
, patatin-like phospholipase domain containing 2
, transport-secretion protein