Patatin-Like phospholipase Domain Containing 2 Proteine (PNPLA2)

PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Zusätzlich bieten wir Ihnen Patatin-Like phospholipase Domain Containing 2 Antikörper (183) und Patatin-Like phospholipase Domain Containing 2 Kits (47) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PNPLA2 57104 Q96AD5
PNPLA2 66853 Q8BJ56
PNPLA2 361676 P0C548
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,349.50
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,375.17
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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PNPLA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,
Rat (Rattus) ,

Am meisten referenzierte Patatin-Like phospholipase Domain Containing 2 Proteine

  1. Human PNPLA2 Protein expressed in Wheat germ - ABIN1315583 : Tavian, Missaglia, Redaelli, Pennisi, Invernici, Wessalowski, Maiwald, Arca, Coleman: Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function. in Human molecular genetics 2012 (PubMed)

Weitere Proteine zu Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartnern

Human Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. No difference in the genotype frequency of rs7925131 or rs7942159 in PNPLA2 between the normal free fatty acids (FFA) group and the high FFA group in a Chinese Han population.

  2. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

  3. Although we found evidence for moderate association between PNPLA2 tagSNPs and anthropometric and metabolic parameters in our cohort, no evidence for association between polymorphisms in the PNPLA2 gene and the presence and severity of non-alcoholic fatty liver disease was identified.

  4. Study reports the derivation of iPSCs from fibroblasts of two Neutral Lipid Storage Disease with Myopathy (NLSDM)patients carrying different ATGL mutations. These iPSCs exhibited defects in neutral lipid metabolism similar to those of NLSDM fibroblasts. NLSDM-iPSCs were able to undergo directed differentiation into cardiomyocytes.

  5. Thus, ATGL in leucocytes may be an important biomarker for the diagnosis of TGCV and our assay may provide insights into pathophysiology and elucidate the underlying mechanism of TGCV and related disorders.

  6. The ATGL gene was frequently deleted in various forms of human cancers and was associated with poor prognosis.

  7. a Snail1 (zeige SNAI1 Proteine)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  8. ABHD5 (zeige ABHD5 Proteine) possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.

  9. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 (zeige ALOX5 Proteine) expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 (zeige PTGR1 Proteine) levels and death of RPE (zeige RPE Proteine) cells undergoing oxidative stress.

  10. Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

Mouse (Murine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. ATGL in brown adipose tissue is not a prerequisite for cold-induced thermogenesis in vivo.

  2. Non-cardiac ATGL-mediated modulation of the cardiac lipidome may play an important role in the pathogenesis of chronic heart failure.

  3. this study shows that long non-coding steroid receptor (zeige ESR2 Proteine) RNA activator promotes hepatic steatosis through repressing the expression of ATGL

  4. ATGL deficiency results in male infertility in mice.

  5. Loss of ATGL induces spontaneous development of pulmonary neoplasia in knockout mouse model.

  6. ATGL acts as an important upstream signaling node that, via SIRT1 (zeige SIRT1 Proteine), increases autophagy/lipophagy as a means to promote hepatic lipid droplet catabolism.

  7. a Snail1 (zeige SNAI1 Proteine)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  8. CGI-58 (zeige ABHD5 Proteine) regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.

  9. Enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles which is HSL (zeige LIPE Proteine)/ATGL-independent.

  10. The Atgl is down-regulated by the basal transcription factor Sp1 (zeige SP1 Proteine) in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 (zeige SP1 Proteine) and peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Proteine)).

Cow (Bovine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.

Pig (Porcine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. Results identified functional polymorphisms providing new evidence of PNPLA2 as an important candidate gene for fat deposition and carcass traits in pigs.

  2. Resveratrol activated sirtuin 1 (Sirt1 (zeige SIRT1 Proteine)) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (zeige SIRT1 Proteine) regulation pattern for PPARgamma (zeige PPARG Proteine) to that of ATGL in adipocytes.

  3. analysis of porcine adipose triglyceride lipase (PNPLA2) gene

  4. JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) and MAPK (zeige MAPK1 Proteine) signaling pathways, as well as PPAR gamma (zeige PPARG Proteine) all played important roles in the ATGL expression mediated by leptin (zeige LEP Proteine)

  5. patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.

  6. ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.

Goat Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation

Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Protein Überblick

Protein Überblick

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.

Genbezeichner und Symbole assoziert mit PNPLA2

  • patatin like phospholipase domain containing 2 (PNPLA2)
  • patatin like phospholipase domain containing 2 (pnpla2)
  • patatin-like phospholipase domain containing 2 (Pnpla2)
  • 0610039C21Rik Protein
  • 1110001C14Rik Protein
  • Atgl Protein
  • iPLA2zeta Protein
  • PEDF-R Protein
  • pnpla2 Protein
  • RGD1309044 Protein
  • TTS-2.2 Protein
  • TTS2 Protein

Bezeichner auf Proteinebene für PNPLA2

IPLA2-zeta , TTS2.2 , adipose triglyceride lipase , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , patatin-like phospholipase domain-containing protein 2 , pigment epithelium-derived factor , transport-secretion protein 2.2 , triglyceride hydrolase , patatin-like phospholipase domain containing 2 , transport-secretion protein , PNPLA2/ATGL

GENE ID SPEZIES
57104 Homo sapiens
611403 Canis lupus familiaris
780152 Xenopus (Silurana) tropicalis
100219060 Taeniopygia guttata
100294555 Meleagris gallopavo
66853 Mus musculus
361676 Rattus norvegicus
431066 Gallus gallus
508493 Bos taurus
100049704 Sus scrofa
100860889 Capra hircus
101123166 Ovis aries
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