anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Antikörper

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Zusätzlich bieten wir Ihnen PARK2 Kits (19) und PARK2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PARK2 5071 O60260
PARK2 56816 Q9JK66
PARK2 50873 Q9WVS6
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Top anti-PARK2 Antikörper auf antikoerper-online.de

Showing 10 out of 180 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-Park2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Mouse Liver WB Suggested Anti-Park2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Mouse Liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IHC, WB Western Blot: Parkin Antibody [ABIN4077841] - Extracts from Jurkat cells. Immunohistochemistry-Paraffin: Parkin Antibody [ABIN4077841] - Paraffin-embedded human brain tissue. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$490.19
Details
Rind (Kuh) Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of Parkin staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of Parkin expression in HepG2 (A), SHSY5Y (B), SW480 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ICC, IHC (p), WB Anti- Parkin Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti- Parkin Picoband antibody, IHC(P) IHC(P): Mouse Brain Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Maus Unkonjugiert IF, WB Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell (antibody concentration 10 µg/mL). PARK2 monoclonal antibody (M01), clone 1H4 Western Blot analysis of PARK2 expression in Jurkat. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from HeLa/HuvEc cells, using Parkin (Ab-131) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Parkin (Ab-131) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using Parkin Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Parkin Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using Parkin (Phospho-Ser131) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB The anti-Parkin C-term Pab (ABIN390366) is used in Western blot to detect Parkin in mouse kidney tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) (ABIN390365) in NCI-H460 cell line lysates (35 µg/lane). PARK2 (Parkin)(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details

PARK2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PARK2 Antikörper

  1. Human Polyclonal PARK2 Primary Antibody für ICC, IF - ABIN407784 : Eid, Ito, Otsuki: Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases. in Frontiers in pharmacology 2016 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal PARK2 Primary Antibody für IHC (p), IP - ABIN269703 : La Cognata, Iemmolo, DAgata, Scuderi, Drago, Zappia, Cavallaro: Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. in Current genomics 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal PARK2 Primary Antibody für ELISA, WB - ABIN251684 : Scuderi, La Cognata, Drago, Cavallaro, DAgata: Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain. in BioMed research international 2014 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal PARK2 Primary Antibody für IF (p), IHC (p) - ABIN735578 : Li, Zhang, Wang, Liu, Yang, Liu, Lu: Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant ?-synuclein. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014 (PubMed)

  5. Human Monoclonal PARK2 Primary Antibody für IF, ELISA - ABIN562106 : Brody, Taylor, Wilson, Delatycki, Lockhart: Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain. in Brain research 2008 (PubMed)

  6. Human Monoclonal PARK2 Primary Antibody für IF, WB - ABIN2476069 : Ostby: [Fredrik Nightingale fellows]. in Journalen sykepleien 1990 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen PARK2 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. This study found learning and memory abnormalities in Parkin mutant genotypes in Drosophila.

  2. parkin mutants have a longer lifespan when fed the 1:16 P:C compared to those fed the 1:2 P:C diet. Parkin mutants fed the 1:16 P:C diet have delayed climbing deficit, increased resistance to starvation. Mutant flies fed the 1:16 P:C diet also have improved mitochondrial functions as evidenced by increased respiratory control ratio

  3. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 (zeige PINK1 Antikörper) in parallel with Parkin

  4. Maintenance of tissue homeostasis upon reduction of Pink1 (zeige PINK1 Antikörper) or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  5. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 (zeige PINK1 Antikörper) and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  6. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

  7. autophosphorylation of PINK1 (zeige PINK1 Antikörper) is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  8. Our data indicate that PINK1 (zeige PINK1 Antikörper) and Parkin play an important role in FUS (zeige FUS Antikörper)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (zeige FUS Antikörper) proteinopathy and PINK1 (zeige PINK1 Antikörper)/Parkin genes, providing new insights into the pathogenesis of FUS (zeige FUS Antikörper) proteinopathy.

  9. Clu (zeige CLU Antikörper) is upstream of and binds to VCP (zeige vcp Antikörper) in vivo and promotes VCP (zeige vcp Antikörper)-dependent Marf (zeige MFN2 Antikörper) degradation in vitro Marf (zeige MFN2 Antikörper) accumulates in whole muscle lysates of clu (zeige CLU Antikörper)-deficient flies and is destabilized upon Clu (zeige CLU Antikörper) overexpression. Thus, Clu (zeige CLU Antikörper) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (zeige vcp Antikörper) for Marf (zeige MFN2 Antikörper) degradation to promote damaged mitochondrial clearance.

  10. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 (zeige PINK1 Antikörper) phenotypes in Drosophila

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Parkin was found to interact with p53 (zeige TP53 Antikörper); however, this was abolished in Parkin KO mice model, which prevented p53 (zeige TP53 Antikörper) degradation reducing inflammatory arthritis.

  2. These findings unveil an important role of Parkin in protecting genome stability through positively regulating translesion DNA synthesis (TLS (zeige FUS Antikörper)) upon UV damage, providing a novel mechanistic link between Parkin deficiency and predisposition to skin cancers in PD patients.

  3. Thus, the present study indicated that parkin knockout inhibits neural stem cell differentiation by JNK (zeige MAPK8 Antikörper)-dependent proteasomal degradation of p21 (zeige CDKN1A Antikörper).

  4. Parkin hyper-activation by pUb(S57 (zeige CD81 Antikörper)) demonstrates the first PINK1 (zeige PINK1 Antikörper)-independent route to active parkin, revealing the roles of multiple ubiquitin phosphorylation sites in governing parkin stimulation and catalytic activity.

  5. the results of this study suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.

  6. MicroRNA-181a has a role in suppressing parkin-mediated mitophagy and sensitizing neuroblastoma (zeige ARHGEF16 Antikörper) cells to mitochondrial uncoupler-induced apoptosis

  7. Findings suggest that PARK2 might have a tumor suppressor role in the development of chronic obstructive pulmonary disease (COPD (zeige ARCN1 Antikörper)) and lung cancer.

  8. Here we review the evidence supporting PINK1 (zeige PINK1 Antikörper)/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.

  9. Although PARK2 may be a pathological factor for neurodevelopmental disorders , likely not all variants are pathogenic, and a conclusive assessment of PARK2 variant pathogenicity requires an accurate analysis of their location within the coding region and encoded functional domains.

  10. VPS35 (zeige vps35 Antikörper) regulates parkin substrate AIMP2 (zeige AIMP2 Antikörper) toxicity by facilitating lysosomal clearance of AIMP2 (zeige AIMP2 Antikörper).

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Melatonin, added together with MPTP (zeige PTPN2 Antikörper) or added once MPTP (zeige PTPN2 Antikörper) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1 (zeige PINK1 Antikörper)/DJ-1 (zeige PARK7 Antikörper)/MUL1 loop and also the normal motor activity of the embryos.

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. crossed Parkin knockouts to the Twinkle-TG mouse in which mtDNA deletions are increased specifically in substantia nigra to determine the effect of increased deletion mutagenesis in the absence of mitochondrial quality control

  2. These findings reveal parkin-mediated cytoprotective mechanisms against misfolded SOD1 (zeige SOD1 Antikörper) toxicity.

  3. Park2 deficiency exacerbates ethanol-induced dopaminergic neuron damage through p38 (zeige CRK Antikörper) kinase dependent inhibition of autophagy and mitochondrial function.

  4. PARK2-dependent acidic postconditioning -induced mitophagy renders the brain resistant to ischemic injury.

  5. Our results indicate that strict maternal transmission of mitochondria relies on mitophagy and uncover a collaboration between MUL1 (zeige MUL1 Antikörper) and PARKIN in this process.

  6. an impaired PINK1 (zeige PINK1 Antikörper)-PARK2-mediated neuroimmunology pathway contributes to septic death.

  7. These findings suggest that insufficient mitophagy-mediated PDGFR (zeige PDGFRB Antikörper)/PI3K/AKT (zeige AKT1 Antikörper) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  8. Mfn2 (zeige MFN2 Antikörper) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (zeige CA2 Antikörper)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  9. Our results provide a molecular explanation for the contribution of Drp1 (zeige CRMP1 Antikörper) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO-Parkin pathway may be a novel therapeutic target to treat PD

  10. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

PARK2 Antigen-Profil

Protein Überblick

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Genbezeichner und Symbole assoziert mit PARK2

  • parkin (park) Antikörper
  • parkin RBR E3 ubiquitin protein ligase (PRKN) Antikörper
  • parkin RBR E3 ubiquitin protein ligase (Prkn) Antikörper
  • parkin RBR E3 ubiquitin protein ligase (prkn) Antikörper
  • parkin (CpipJ_CPIJ014867) Antikörper
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) Antikörper
  • AR-JP Antikörper
  • CG10523 Antikörper
  • Dmel\\CG10523 Antikörper
  • Dpark Antikörper
  • dpk Antikörper
  • LPRS2 Antikörper
  • Park Antikörper
  • PARK2 Antikörper
  • PDJ Antikörper
  • pdr-1 Antikörper
  • Prkn Antikörper
  • SD01679 Antikörper
  • si:ch211-123f21.1 Antikörper
  • zgc:112390 Antikörper

Bezeichner auf Proteinebene für PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkinson juvenile disease protein 2 , parkin variant SV5DEL , parkin , parkin protein , parkinson protein 2, E3 ubiquitin protein ligase (parkin)

GENE ID SPEZIES
40336 Drosophila melanogaster
5071 Homo sapiens
56816 Rattus norvegicus
550328 Danio rerio
733673 Sus scrofa
741350 Pan troglodytes
6049109 Culex quinquefasciatus
50873 Mus musculus
612316 Canis lupus familiaris
100724550 Cavia porcellus
530858 Bos taurus
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