Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Zusätzlich bieten wir Ihnen PARK2 Kits (19) und PARK2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 180 products:
Human Polyclonal PARK2 Primary Antibody für ICC, IF - ABIN407784
Eid, Ito, Otsuki: Triggering of Parkin Mitochondrial Translocation in Mitophagy: Implications for Liver Diseases. in Frontiers in pharmacology 2016
Show all 4 Pubmed References
Human Polyclonal PARK2 Primary Antibody für IHC (p), IP - ABIN269703
La Cognata, Iemmolo, DAgata, Scuderi, Drago, Zappia, Cavallaro: Increasing the Coding Potential of Genomes Through Alternative Splicing: The Case of PARK2 Gene. in Current genomics 2014
Show all 2 Pubmed References
Human Polyclonal PARK2 Primary Antibody für ELISA, WB - ABIN251684
Scuderi, La Cognata, Drago, Cavallaro, DAgata: Alternative splicing generates different parkin protein isoforms: evidences in human, rat, and mouse brain. in BioMed research international 2014
Show all 2 Pubmed References
Human Polyclonal PARK2 Primary Antibody für IF (p), IHC (p) - ABIN735578
Li, Zhang, Wang, Liu, Yang, Liu, Lu: Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutant ?-synuclein. in Phytomedicine : international journal of phytotherapy and phytopharmacology 2014
Human Monoclonal PARK2 Primary Antibody für IF, ELISA - ABIN562106
Brody, Taylor, Wilson, Delatycki, Lockhart: Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain. in Brain research 2008
Human Monoclonal PARK2 Primary Antibody für IF, WB - ABIN2476069
Ostby: [Fredrik Nightingale fellows]. in Journalen sykepleien 1990
Show all 2 Pubmed References
This study found learning and memory abnormalities in Parkin mutant genotypes in Drosophila.
parkin mutants have a longer lifespan when fed the 1:16 P:C compared to those fed the 1:2 P:C diet. Parkin mutants fed the 1:16 P:C diet have delayed climbing deficit, increased resistance to starvation. Mutant flies fed the 1:16 P:C diet also have improved mitochondrial functions as evidenced by increased respiratory control ratio
Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 (zeige PINK1 Antikörper) in parallel with Parkin
Maintenance of tissue homeostasis upon reduction of Pink1 (zeige PINK1 Antikörper) or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.
activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 (zeige PINK1 Antikörper) and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.
Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.
autophosphorylation of PINK1 (zeige PINK1 Antikörper) is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.
Our data indicate that PINK1 (zeige PINK1 Antikörper) and Parkin play an important role in FUS (zeige FUS Antikörper)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (zeige FUS Antikörper) proteinopathy and PINK1 (zeige PINK1 Antikörper)/Parkin genes, providing new insights into the pathogenesis of FUS (zeige FUS Antikörper) proteinopathy.
Clu (zeige CLU Antikörper) is upstream of and binds to VCP (zeige vcp Antikörper) in vivo and promotes VCP (zeige vcp Antikörper)-dependent Marf (zeige MFN2 Antikörper) degradation in vitro Marf (zeige MFN2 Antikörper) accumulates in whole muscle lysates of clu (zeige CLU Antikörper)-deficient flies and is destabilized upon Clu (zeige CLU Antikörper) overexpression. Thus, Clu (zeige CLU Antikörper) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (zeige vcp Antikörper) for Marf (zeige MFN2 Antikörper) degradation to promote damaged mitochondrial clearance.
Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 (zeige PINK1 Antikörper) phenotypes in Drosophila
Parkin was found to interact with p53 (zeige TP53 Antikörper); however, this was abolished in Parkin KO mice model, which prevented p53 (zeige TP53 Antikörper) degradation reducing inflammatory arthritis.
These findings unveil an important role of Parkin in protecting genome stability through positively regulating translesion DNA synthesis (TLS (zeige FUS Antikörper)) upon UV damage, providing a novel mechanistic link between Parkin deficiency and predisposition to skin cancers in PD patients.
Thus, the present study indicated that parkin knockout inhibits neural stem cell differentiation by JNK (zeige MAPK8 Antikörper)-dependent proteasomal degradation of p21 (zeige CDKN1A Antikörper).
Parkin hyper-activation by pUb(S57 (zeige CD81 Antikörper)) demonstrates the first PINK1 (zeige PINK1 Antikörper)-independent route to active parkin, revealing the roles of multiple ubiquitin phosphorylation sites in governing parkin stimulation and catalytic activity.
the results of this study suggest that mutations on specific genes (PARK2 and LRRK2) compromising basal ganglia functioning may be subtly related to language-processing mechanisms.
MicroRNA-181a has a role in suppressing parkin-mediated mitophagy and sensitizing neuroblastoma (zeige ARHGEF16 Antikörper) cells to mitochondrial uncoupler-induced apoptosis
Findings suggest that PARK2 might have a tumor suppressor role in the development of chronic obstructive pulmonary disease (COPD (zeige ARCN1 Antikörper)) and lung cancer.
Here we review the evidence supporting PINK1 (zeige PINK1 Antikörper)/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.
Although PARK2 may be a pathological factor for neurodevelopmental disorders , likely not all variants are pathogenic, and a conclusive assessment of PARK2 variant pathogenicity requires an accurate analysis of their location within the coding region and encoded functional domains.
VPS35 (zeige vps35 Antikörper) regulates parkin substrate AIMP2 (zeige AIMP2 Antikörper) toxicity by facilitating lysosomal clearance of AIMP2 (zeige AIMP2 Antikörper).
Melatonin, added together with MPTP (zeige PTPN2 Antikörper) or added once MPTP (zeige PTPN2 Antikörper) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1 (zeige PINK1 Antikörper)/DJ-1 (zeige PARK7 Antikörper)/MUL1 loop and also the normal motor activity of the embryos.
Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7
crossed Parkin knockouts to the Twinkle-TG mouse in which mtDNA deletions are increased specifically in substantia nigra to determine the effect of increased deletion mutagenesis in the absence of mitochondrial quality control
These findings reveal parkin-mediated cytoprotective mechanisms against misfolded SOD1 (zeige SOD1 Antikörper) toxicity.
Park2 deficiency exacerbates ethanol-induced dopaminergic neuron damage through p38 (zeige CRK Antikörper) kinase dependent inhibition of autophagy and mitochondrial function.
PARK2-dependent acidic postconditioning -induced mitophagy renders the brain resistant to ischemic injury.
Our results indicate that strict maternal transmission of mitochondria relies on mitophagy and uncover a collaboration between MUL1 (zeige MUL1 Antikörper) and PARKIN in this process.
an impaired PINK1 (zeige PINK1 Antikörper)-PARK2-mediated neuroimmunology pathway contributes to septic death.
These findings suggest that insufficient mitophagy-mediated PDGFR (zeige PDGFRB Antikörper)/PI3K/AKT (zeige AKT1 Antikörper) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis
Mfn2 (zeige MFN2 Antikörper) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (zeige CA2 Antikörper)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development
Our results provide a molecular explanation for the contribution of Drp1 (zeige CRMP1 Antikörper) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO-Parkin pathway may be a novel therapeutic target to treat PD
These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.
The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
, E3 ubiquitin-protein ligase parkin
, Parkinson disease (autosomal recessive, juvenile) 2, parkin
, parkinson juvenile disease protein 2
, parkin variant SV5DEL
, parkin protein
, parkinson protein 2, E3 ubiquitin protein ligase (parkin)