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PAX7 is a member of the paired box (PAX) family of transcription factors.
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These data suggested that expression of the myogenic regulatory transcription factors are dependent upon expression of glypican-1 (zeige GPC1 ELISA Kits) and syndecan-4 (zeige SDC4 ELISA Kits) during satellite cell proliferation and differentiation, and Pax7 expression is influenced by glypican-1 (zeige GPC1 ELISA Kits).
Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3.
The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.
EWSR1 (zeige EWSR1 ELISA Kits) fusion protein is required for PAX7 expression in Ewing sarcoma and identify a candidate EWSR1 (zeige EWSR1 ELISA Kits)-FLI1 (zeige FLI1 ELISA Kits)-bound PAX7 enhancer that coincides with both a consensus GGAA repeat-containing binding site and a peak of regulatory H3K27 acetylation.
miR (zeige MLXIP ELISA Kits)-206 acts as a tumor suppressor in fusion-negative RMS at least partially through downregulation of PAX7.
PAX7 expression is a useful marker of skeletal muscle differentiation in rhabdomyosarcoma, particularly of the embryonal subtype, with specificity for rhabdomyosarcoma and Ewing sarcoma.
NTN1 (zeige NTN1 ELISA Kits) rs9788972 is identified as a risk locus for nonsyndromic orofacial clefts susceptibility in a northern Chinese population; SNPs in PAX7 were not associated with any increased risk
Our results on Pax7 and MyoD protein expression suggest that proliferation and differentiation of skeletal muscle stem cells are affected in ALS patients, and the myogenic processes cannot overcome the denervation-induced wasting.
these results suggest that sarcoma metastasis can be partially controlled through Pax7/MyoD (zeige MYOD1 ELISA Kits)-dependent activation of miR (zeige MLXIP ELISA Kits)-182 and provide insight into the role that myogenic transcription factors have in sarcoma progression
RAGE (zeige AGER ELISA Kits) upregulates myogenin (zeige MYOG ELISA Kits) which upregulates MyoD (zeige MYOD1 ELISA Kits) and downregulates PAX7, with consequent inhibition of proliferation and stimulation of differentiation.
Pax7 responds to NF-kappaB (zeige NFKB1 ELISA Kits) by impairing the regenerative capacity of myogenic cells in the muscle microenvironment to drive muscle wasting in cancer.
Our results show that the expression of Pax6 (zeige PAX6 ELISA Kits) and Pax7 is widely maintained in the adult brain of Xenopus
The Pax3 (zeige PAX3 ELISA Kits) and Pax7 paralogs cooperate in neural and neural crest patterning using distinct molecular mechanisms, in Xenopus laevis embryos.
Results show that inhibition of pax7 does not prevent differentiation of satellite cells to myofibres, but it does prevent their maintenance as a stem cell population.
four novel polymorphisms were identified in the Pax7 gene; the association analysis of genotypes in the single and combined SNP(s) revealed consistent effects on growth traits in NY cattle
Pax7 activates Zac1 to regulate GPR39 expression in myocytes.
Barx2 and Pax7 regulate the canonical Wnt (zeige WNT2 ELISA Kits) target gene Axin2 (zeige AXIN2 ELISA Kits), which mediates critical feedback to terminate the transcriptional response to Wnt (zeige WNT2 ELISA Kits) signals.
Stat3 (zeige STAT3 ELISA Kits) regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7.
Lkb1 (zeige STK11 ELISA Kits) activates the Notch (zeige NOTCH1 ELISA Kits) signaling pathway, which subsequently increases Pax7 expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 (zeige STK11 ELISA Kits) regulates Notch (zeige NOTCH1 ELISA Kits) activation through AMPK (zeige PRKAA1 ELISA Kits)-mTOR (zeige FRAP1 ELISA Kits) pathway in myoblasts.
Pax7 binding induces dramatic, localized remodeling of chromatin characterized by the acquisition of histone marks associated with enhancer activity and induction of chromatin accessibility in both muscle precursors and lineage-committed myoblasts. Conversely, removal of Pax7 leads to rapid reversal of these features on a subset of enhancers.
the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation.
findings demonstrate a key role for the lingual epithelial signals in supporting the integrity of the lamina propria and muscular tissue during tongue development and that a Wnt (zeige WNT2 ELISA Kits)/Notch (zeige NOTCH1 ELISA Kits)/Pax7 genetic hierarchy is involved in this development.
results support the concept that lack of functional Pax7 promotes proliferation of differentiating ESCs and for this reason more of them can turn into myogenic lineage.
Cells marked by pax7a only or by both pax7a and pax7b enter the wound rapidly and contribute to muscle wound repair, but each behaves differently.
Pax7 is required for adult skeletal muscle repair.
Pax7 identifies neural crest, chromatophore lineages and pigment stem cells during development.
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.
paired box 7
, paired box gene 7
, transcription factor pax-7
, PAX7 transcriptional factor
, paired box homeotic gene 7
, paired box protein Pax-7
, paired domain gene 7
, myogenic specification paired-box transcription factor Pax7
, paired box transcription factor PAX7
, paired box homeotic gene 7a
, paired box homeotic gene 7c
, paired box homeotic gene 7d
, paired box homeotic gene 7e