PROP Paired-Like Homeobox 1 Proteine (PROP1)

PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Zusätzlich bieten wir Ihnen PROP1 Antikörper (30) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PROP1 19127 P97458
PROP1 5626 O75360
Ratte PROP1 PROP1 266738  
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Top PROP1 Proteine auf antikoerper-online.de

Showing 9 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
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Hefe Hund His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
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Hefe REACT_Old World Monkey His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
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Hefe REACT_Capuchin Monkey His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
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Hefe REACT_Howler monkey His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
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PROP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Am meisten referenzierte PROP1 Proteine

  1. Human PROP1 Protein expressed in HEK-293 Cells - ABIN2729760 : Bando, Iguchi, Fukuoka, Yamamoto, Hidaka-Takeno, Okimura, Matsumoto, Suda, Nishizawa, Takahashi, Tojo, Takahashi: Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome. in The Journal of clinical endocrinology and metabolism 2014 (PubMed)

Weitere Proteine zu PROP Paired-Like Homeobox 1 (PROP1) Interaktionspartnern

Mouse (Murine) PROP Paired-Like Homeobox 1 (PROP1) Interaktionspartner

  1. Genomic profiling reveals that PROP1 binds to genes expressed in epithelial cells like Claudin 23, and to epithelial-mesenchymal transition inducer genes like Zeb2, Notch2 and Gli2. Zeb2 activation appears to be a key step in the epithelial-mesenchymal transition process.

  2. SOX2 is a regulatory factor of Prop1 expression

  3. Data show that human paired like homeodomain factor 1 (PROP1) can substitute functionally for mouse Prop1.

  4. endocochlear potential and KCNJ10 immunostaining in the stria vascularis are indistinguishable from wild type, and no differences in neurofilament or synaptophysin staining are evident in Prop1(df) mutants

  5. Data report the spatial and temporal regulation of Otx2 in normal mice and Prop1 mutant.

  6. Several components of the main GH-signaling pathways exhibit enhanced sensitivity to the hormone in liver and muscle of Ames dwarf mice.

  7. Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.

  8. Lhx4 and Prop1 have critical, but mechanistically different roles in specification and expansion of specialized anterior pituitary cells

  9. Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1

  10. PROP1 has a role in pituitary gland growth

  11. variation in PROP1 expression could affect the growth spurt and the onset of puberty in humans.

  12. Prop-1 modulates the synthesis of FSH at the transcriptional level.

  13. Functional transcriptional control sequences in the Prop1 gene for spatial expression during pituitary development.

  14. These data reveal important overlapping functions of Hes1 and Prop1 in cell differentiation and movement that are critical for pituitary organogenesis.

Human PROP Paired-Like Homeobox 1 (PROP1) Interaktionspartner

  1. PROP1 mutations are a prevalent cause of congenital CPHD with OPP, and therefore, PROP1 sequencing must be the first step of molecular investigation in patients with CPHD and OPP, especially in populations with a high frequency of PROP1 mutations.

  2. Deletion in the PROP1 gene is associated with Combined pituitary hormone deficiency.

  3. The anterior pituitary gland comprised specialized cell-types that arise from stem cells expressing SOX2 and PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. [review]

  4. GH replacement successfully corrects the growth deficit in children with Growth Hormone Deficiency . While the genetic aetiology remains undefined in most cases of Isolated Growth Hormone Deficiency , PROP1 mutations constitute a major cause for Multiple Pituitary Hormone Deficiencies. Persistence of Growth Hormone Deficiency into adulthood is related to abnormal pituitary morphology.

  5. The present study reports on screening of POU1F1, PROP1, and HESX1 in combined pituitary hormone deficiency patients and the novel variations identified.

  6. A compound heterozygosity in the PROP1 gene has been identified for both probands. The first change represents a mutational hot spot (c.150delA, p.R53fsX164), whereas the second is a novel alteration (p.R112X) that leads to protein disruption. The resulting clinical phenotype was surprisingly distinct compared to most patients with genetic alterations in PROP1.

  7. the most frequent variants in the PROP1 gene are not a consequence of variant hot spots as previously assumed, but are founder variants.

  8. Data show that human paired like homeodomain factor 1 (PROP1) can substitute functionally for mouse Prop1.

  9. A novel heterozygous mutation in the HESX1 gene and a novel homozygous mutation in the PROP1 gene were detected in 2 pedigrees with combined pituitary hormone deficiency

  10. The c.301_302delAG homozygous genotype had a high frequency of 38%, reaching 100% in group with familial cases of multiple pituitary hormone deficiency and 16% in group with sporadic forms of MPHD.

  11. investigated the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey

  12. The p.R73C PROP1 mutation was the most frequent mutation in Congenital hypopituitarism in a Moroccan cohort.

  13. The various levels of specific miRNAs, particularly miR-593 and miR-511 whose direct target is the PROP1 gene, may serve as a non-invasive diagnostic biomarkers for children with CPHD.

  14. mutations in the PROP-1 gene in cases with CPHD were expected to be more prevalent in our population due to consanguinity, but it was found that these mutations were far less than expected and that it was rare in non-familial cases.

  15. High prevalence of PROP1 defects in Lithuania is due to 296delGA mutation, suggesting a founder effect.

  16. A homozygous frameshift mutation of PROP1 (296delGA) was identified in siblings. Defects in PROP1 cause progressive deficiency of multiple pituitary hormones; PROP1 deficiency may present as isolated central hypothyroidism at a very young age

  17. AES binds to PROP1 and represses its expression; PROP1 mutation is a likely cause of combined pituitary hormone deficiency.

  18. Case Report: unfavourable long-term course of an untreated patient with PROP-1 gene mutation-associated combined pituitary horme deficiency.

  19. Peculiar prolactinomas in patients with pituitary developmental PROP1 gene mutations

  20. Variations with a functional significance conferring susceptibility to combined growth hormone deficiency have been identified in the PROP1 gene

Pig (Porcine) PROP Paired-Like Homeobox 1 (PROP1) Interaktionspartner

  1. Data suggest that formation of a heterodimer between HESX1 and PROP1 allows HESX1 to become active, and that PROP1 then replaces HESX1 to advance to the middle stage of pituitary development.

  2. Prop-1 participates in the regulation of FSHbeta gene

  3. Prop-1 might be involved in development of gonadotropes and hormone production

  4. Dimeric binding of PROP1 is able to recognize diverse palindromic TAAT sequences separated by 3 nucleotides and to exhibit its transcriptional activity.

Cow (Bovine) PROP Paired-Like Homeobox 1 (PROP1) Interaktionspartner

  1. The H173R mutation in PROP1 can be considered as a DNA marker for selecting individuals with superior growth traits, thereby contributing to research on breeding and genetics in the beef industry.

  2. missense mutation affects male fertility and milk production traits in Holsteins

PROP1 Protein Überblick

Protein Überblick

This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.

Genbezeichner und Symbole assoziert mit PROP1

  • paired like homeodomain factor 1 (Prop1)
  • PROP paired-like homeobox 1 (PROP1)
  • PROP paired-like homeobox 1 (Prop1)
  • CPHD2 Protein
  • df Protein
  • PROP-1 Protein

Bezeichner auf Proteinebene für PROP1

Ames dwarf , homeobox protein prophet of Pit-1 , pituitary specific homeodomain factor , pituitary-specific homeodomain factor , prophet of Pit-1 , PROP paired-like homeobox 1 , prophet of Pit1, paired-like homeodomain transcription factor , PROP-1 , paired like homeodomain factor 1 , prophet of Pit1 paired-like homeodomain transcription factor

GENE ID SPEZIES
19127 Mus musculus
374220 Gallus gallus
5626 Homo sapiens
474647 Canis lupus familiaris
397280 Sus scrofa
282563 Bos taurus
266738 Rattus norvegicus
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