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The PR domain is a protein-protein interaction module of about 100 amino acids. Zusätzlich bieten wir Ihnen PRDM9 Antikörper (48) und PRDM9 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
The most common genetic variant of PRDM9 is allele A (PRDM9a) which contains 13 Cys2-His2 (zeige HTN3 ELISA Kits) zinc fingers (ZF); the second-most common variant among African populations is allele C (PRDM9c), which contains 14 Cys2-His2 (zeige HTN3 ELISA Kits) ZF. Data suggest that Ser764 in ZF9 (zeige KLF6 ELISA Kits) allows PRDM9c to accommodate a variable base, whereas PRDM9a Arg764 recognizes a conserved guanine.
The article outlines the role of PRDM9 in fertility.
PRDM9 protein variants form functional heteromeric complexes which can bind hotspots sequences. When a heteromeric complex binds at a hotspot of one PRDM9 variant, the other PRDM9 variant, which would otherwise not bind, methylates hotspot nucleosomes
subspecies-specific degradation of PRDM9 binding sites by meiotic drive, which steadily increases asymmetric PRDM9 binding, has impacts beyond simply changing hotspot positions, and strongly support a direct involvement in hybrid infertility
Alignment of Neandertal and Denisovan sequences suggests that PRDM9 in archaic hominins was closely related to present-day human alleles that are rare and specific to African populations.
This depletion of PRDM9 genomic targets is expected to decrease fitness, and thereby to favor new PRDM9 alleles binding different motifs
Results confirm an association between rare variant PRDM9 alleic forms and childhood ALL
Overexpression of PRDM9 in HEK293 cells also resulted in a significant increase in trimethylated H3K36 and H3K4 further confirming our in vitro observations
We identified PRDM9 as being associated with unusual recombination patterns and discovered a substantial excess of rare allelic forms of PRDM9 in two independent acute lymphoblastic leukemia cohorts.
Recombination regulator PRDM9 influences the instability of its own coding sequence in humans.
the overexpression of alternative transcripts was apparently insufficient for Prdm9 function or for increasing the fertility of the hybrid males.
Discovery and characterization of the automethylation properties of PRDM9 has been reported.
genetic factors, the Prdm9 gene and the Hstx2/Meir1 genomic locus, indicate a link between meiotic recombination and hybrid sterility
results on the developmental time course for nuclear localization of PRDM9 establish its direct window of function and demonstrate the independence of chromosome axial element formation from concurrent PRDM9-mediated activation of recombination hotspots
Together these data support a model where haplotype-specific PRDM9 binding directs biased gene conversion at hotspots, ultimately leading to hotspot erosion.
M. musculus Prdm9 displays an extraordinarily high level of polymorphism, particularly in regions encoding zinc finger repeats, which recognize recombination hotspots.
Our results indicate extended functional consequences of Prdm9-Chr X intersubspecific incompatibility on the fertility of hybrids.
PRDM9 binding actively reorganizes nucleosomes into a symmetrical pattern, creating an extended nucleosome-depleted region.
Histone methyltransferase PRDM9 operates on histone octamers as its substrates.
findings implicate the PRDM9 gene in meiotic recombination; involvement of PRDM9, which causes histone H3 (zeige HIST3H3 ELISA Kits) lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes
We fine-map three QTL and present strong evidence that genetic variants in REC8 (zeige REC8 ELISA Kits) and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM9, are often involved in transcriptional regulation (Jiang and Huang, 2000
PR domain containing 9
, zinc finger protein 436
, PR domain zinc finger protein 9
, histone-lysine N-methyltransferase PRDM9
, minisatellite binding protein 3 (115kD)
, minisatellite binding protein 3, 115kDa
, PR domain-containing protein 9
, PR-domain zinc finger protein
, VPR domain containing 9
, hybrid sterility protein 1
, meiosis-induced factor containing a PR/SET domain and zinc-finger motif
, PR domain containing 7
, XFDL 141
, zinc finger protein XFDL 141
, PR domain containing 7-like
, histone-lysine N-methyltransferase PRDM9-like