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Aberrant hypermethylation is particularly observed in PRDM8 and this may support identification and classification of bone marrow failure syndromes
alteration of hydroxymethylation and methylation of PRDM8 correlates with changes in its expression in the peripheral blood of children with DS. Given the proposed function of PRDM8 in cognitive disability in DS
Zebrafish prdm8a and prdm8b genes were generated by the teleost-specific whole-genome duplication event. Their distinct expression patterns reflect a subfunctionalization, by which prdm8a and prdm8b partition different functions of the ancestral gene.
Our findings highlight the critical role of Ebf3 in multipolar-to-bipolar transition via positive feedback regulation of NeuroD1 in the developing neocortex.
findings establish that PRDM8 is required for RB and type 2 OFF-CB cell survival and amacrine subtype identity, and they present PRDM8 as a candidate gene for human CSNB
Prdm8 regulates the morphological transition at multipolar phase during neocortical development.
These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11.
These results show that Prdm8 expression is tightly regulated in a spatio-temporal manner during neural development and mainly restricted to postmitotic neurons, except in the spinal cord.
PRDM8 repressed the expression of steroidogenic markers, p450c17c and LHR, which indicates its regulatory role in mouse testis development.
May be involved in transcriptional regulation.
PR domain containing 8
, PR domain zinc finger protein 8-like
, PR domain zinc finger protein 8
, PR domain-containing protein 8
, PR-domain containing protein 8