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PRDM14 encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators.
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Human Polyclonal PRDM14 Primary Antibody für IF, IHC (p) - ABIN388018
Jiang, Huang: The yin-yang of PR-domain family genes in tumorigenesis. in Histology and histopathology 2000
Show all 5 Pubmed References
Cow (Bovine) Polyclonal PRDM14 Primary Antibody für ELISA - ABIN4239519
Chia, Chan, Feng, Lu, Orlov, Moreau, Kumar, Yang, Jiang, Lau, Huss, Soh, Kraus, Li, Lufkin, Lim, Clarke, Bard, Ng: A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. in Nature 2010
Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains.
Results identified GRP78 (zeige HSPA5 Antikörper) and HSP90a (zeige HSP90AA1 Antikörper) as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14.
miR (zeige MLXIP Antikörper)-424-->cdc42 (zeige CDC42 Antikörper)-->prdm14 axis as a key molecular signalling cascade that might influence breast cancer progression in diabetic patients through hyperactivation of cancer stem cells.
High expression of PRDM14 is associated with liver metastasis in pancreatic cancer.
PRDM14 role in cell proliferation and cell migration
PRDM14 bears a single PR domain and six tandemly repeated zinc fi ngers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor . [review]
In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression.
The contribution of methylation-mediated gene silencing of PRDM14 to apoptosis evasion in HPV-positive cancer cells offers novel therapeutic options for HPV-induced cancers.
PRDM14 associated with cell differentiation in NSCLC.
Study reveals a repressive role of PRDM14 in the maintenance and induction of pluripotency and identifies PRDM14 as a new regulator of PRC2.
PRDM14 recruited OCT3/4 (zeige POU5F1 Antikörper) to the enhancer regions of naive pluripotency genes via TET-base excision repair-mediated demethylation.
JARID2 (zeige JARID2 Antikörper) physically interacts with ESRRB (zeige ESRRB Antikörper), SALL4A (zeige SALL4 Antikörper), and PRDM14
This repressive function is mediated through an ETO (zeige RUNX1T1 Antikörper)-family co-repressor Mtgr1 (zeige CBFA2T2 Antikörper), which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic targets in mouse embryonic stem cells.
the H3K27-specific demethylase (zeige MBD2 Antikörper) Utx (zeige KDM6A Antikörper) regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist.
Both TET1 (zeige TET1 Antikörper) and TET2 (zeige TET2 Antikörper) are required for the repression of embryonic stem cells differentiation by PRDM14.
Upregulation of Prdm14 results in a highly homogeneous population of authentic pluripotent colonies and prevents the abnormal silencing of the Dlk1 (zeige DLK1 Antikörper)-Dio3 (zeige DIO3 Antikörper) locus.
PRDM14 is heterogeneously expressed in 4-cell-stage embryos. Forced expression of PRDM14 at the 2-cell stage leads to increased H3R26me2 and can induce a pluripotent ICM fate.
PRDM14-induced leukemic cells contain high levels of activated NOTCH1 (zeige NOTCH1 Antikörper) and downstream NOTCH1 (zeige NOTCH1 Antikörper) targets, including MYC (zeige MYC Antikörper) and HES1 (zeige HES1 Antikörper), and are sensitive to pharmacological inhibition of NOTCH1 (zeige NOTCH1 Antikörper) with the gamma-secretase inhibitor DAPT
PRDM14 physically interacts with TET1 (zeige TET1 Antikörper) and TET2 (zeige TET2 Antikörper) and enhances the recruitment of TET1 (zeige TET1 Antikörper) and TET2 (zeige TET2 Antikörper) at target loci. Knockdown of TET1 (zeige TET1 Antikörper) and TET2 (zeige TET2 Antikörper) impaired transcriptional regulation and DNA demethylation by PRDM14.
Prdm14 regulates Caudal (zeige CAD Antikörper) primary axon outgrowth through activation of islet2 expression.
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
PR domain zinc finger protein 14
, PR domain-containing protein 14
, PR domain containing 14
, PR domain zinc finger protein 14-like
, PR domain 14
, PR domain containing 14-like