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PRDM14 encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. Zusätzlich bieten wir Ihnen PRDM14 Proteine (5) und PRDM14 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PRDM14 Primary Antibody für IF, IHC (p) - ABIN388018
Jiang, Huang: The yin-yang of PR-domain family genes in tumorigenesis. in Histology and histopathology 2000
Show all 5 Pubmed References
Cow (Bovine) Polyclonal PRDM14 Primary Antibody für ELISA - ABIN4239519
Chia, Chan, Feng, Lu, Orlov, Moreau, Kumar, Yang, Jiang, Lau, Huss, Soh, Kraus, Li, Lufkin, Lim, Clarke, Bard, Ng: A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. in Nature 2010
Human Polyclonal PRDM14 Primary Antibody für IHC (p), ELISA - ABIN543358
Nishikawa, Toyota, Suzuki, Honma, Fujikane, Ohmura, Nishidate, Ohe-Toyota, Maruyama, Sonoda, Sasaki, Urano, Imai, Hirata, Tokino: Gene amplification and overexpression of PRDM14 in breast cancers. in Cancer research 2007
Our results suggest that PRDM14 serves as an initial trigger for epigenetic changes and hyperdynamic plasticity in tumors via bivalent chromatin domains.
Results identified GRP78 and HSP90a as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14.
miR-424-->cdc42-->prdm14 axis as a key molecular signalling cascade that might influence breast cancer progression in diabetic patients through hyperactivation of cancer stem cells.
High expression of PRDM14 is associated with liver metastasis in pancreatic cancer.
PRDM14 role in cell proliferation and cell migration
PRDM14 bears a single PR domain and six tandemly repeated zinc fi ngers, which is involved in the process of the deacetylation and methylation of the histone, and is involved in the formation of tumor . [review]
In response to cytokines, pluripotent stem cells differentiate first into a heterogeneous mesoderm-like cell population and then into Primordial Germ cell-Like Cells, which exhibit minimal PRDM14 expression.
The contribution of methylation-mediated gene silencing of PRDM14 to apoptosis evasion in HPV-positive cancer cells offers novel therapeutic options for HPV-induced cancers.
PRDM14 associated with cell differentiation in NSCLC.
Study reveals a repressive role of PRDM14 in the maintenance and induction of pluripotency and identifies PRDM14 as a new regulator of PRC2.
The high expression of PRDM14 in non-small cell lung cancer is associated with differentiation and histological type.
novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells
PRDM14 mRNA is overexpressed in about two thirds of breast cancers; moreover, immunohistochemical analysis showed that expression of PRDM14 protein is also up-regulated.
These results suggest that PRDM14 is involved in the maintenance of the self-renewal of human ES cells by suppression of gene expression.
Prdm14 regulates Caudal primary axon outgrowth through activation of islet2 expression.
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer.
PR domain zinc finger protein 14
, PR domain-containing protein 14
, PR domain containing 14
, PR domain zinc finger protein 14-like
, PR domain 14
, PR domain containing 14-like